CC28A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC28A_HUMAN
• UniProt AC: Q8IWP9
• Protein Name: Coiled-coil domain-containing protein 28A
• Gene Name: CCDC28A
• Organism: Homo sapiens (Human).
• Sequence Length: 274
• Protein Sequence: MPRAEPRATLGEQEKAGLPLGAWRLYLLRHFRKQTELRRSGSRDVTGALLVAAAVASEAVGSLRVAEGGPNTLLLQVLRSWPWCNKELKTMEERKVKRRSPKSFSAHCTQVVNAKKNAIPVSKSTGFSNPASQSTSQRPKLKRVMKEKTKPQGGEGKGAQSTPIQHSFLTDVSDVQEMERGLLSLLNDFHSGKLQAFGNECSIEQMEHVRGMQEKLARLNLELYGELEELPEDKRKTASDSNLDRLLSDLEELNSSIQKLHLADAQDVPNTSAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	PLGAWRLYLLRHFRK CHHHHHHHHHHHHHH	8.63	17287340
95	Acetylation	LKTMEERKVKRRSPK HHHHHHHHHHHCCCC	56.22	7668735
100	Phosphorylation	ERKVKRRSPKSFSAH HHHHHHCCCCCHHHH	40.49	29214152
103	Phosphorylation	VKRRSPKSFSAHCTQ HHHCCCCCHHHHHHH	28.02	25159151
105	Phosphorylation	RRSPKSFSAHCTQVV HCCCCCHHHHHHHHH	24.97	29978859
109	Phosphorylation	KSFSAHCTQVVNAKK CCHHHHHHHHHCCCC	17.96	29978859
135	Phosphorylation	SNPASQSTSQRPKLK CCCCCCCCCCCHHHH	22.65	28555341
136	Phosphorylation	NPASQSTSQRPKLKR CCCCCCCCCCHHHHH	29.46	-
161	Phosphorylation	GEGKGAQSTPIQHSF CCCCCCCCCCCCCCC	35.30	29978859
162	Phosphorylation	EGKGAQSTPIQHSFL CCCCCCCCCCCCCCC	16.60	29978859
167	Phosphorylation	QSTPIQHSFLTDVSD CCCCCCCCCCCCHHH	12.94	29978859
170	Phosphorylation	PIQHSFLTDVSDVQE CCCCCCCCCHHHHHH	32.14	29978859
173	Phosphorylation	HSFLTDVSDVQEMER CCCCCCHHHHHHHHH	34.57	29978859
184	Phosphorylation	EMERGLLSLLNDFHS HHHHHHHHHHHHHHH	35.53	28348404
224	Phosphorylation	ARLNLELYGELEELP HHHCHHHHHHHHHCC	10.12	27642862
237	Phosphorylation	LPEDKRKTASDSNLD CCCCHHHCCCHHHHH	35.11	26434776
239	Phosphorylation	EDKRKTASDSNLDRL CCHHHCCCHHHHHHH	46.97	21815630
241	Phosphorylation	KRKTASDSNLDRLLS HHHCCCHHHHHHHHH	36.48	26434776
248	Phosphorylation	SNLDRLLSDLEELNS HHHHHHHHHHHHHHH	44.75	28450419
255	Phosphorylation	SDLEELNSSIQKLHL HHHHHHHHHHHHHHH	41.25	25159151
256	Phosphorylation	DLEELNSSIQKLHLA HHHHHHHHHHHHHHH	28.15	21815630
271	Phosphorylation	DAQDVPNTSAS---- CHHCCCCCCCC----	21.43	27134283
271	O-linked_Glycosylation	DAQDVPNTSAS---- CHHCCCCCCCC----	21.43	28657654
272	Phosphorylation	AQDVPNTSAS----- HHCCCCCCCC-----	32.91	28985074
274	O-linked_Glycosylation	DVPNTSAS------- CCCCCCCC-------	40.29	28657654
274	Phosphorylation	DVPNTSAS------- CCCCCCCC-------	40.29	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC28A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC28A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC28A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI54_HUMAN	TRIM54	physical	25416956
KRA92_HUMAN	KRTAP9-2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-26, AND MASSSPECTROMETRY.
PubMed: 17287340