ICA1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ICA1L_HUMAN
• UniProt AC: Q8NDH6
• Protein Name: Islet cell autoantigen 1-like protein
• Gene Name: ICA1L
• Organism: Homo sapiens (Human).
• Sequence Length: 482
• Protein Sequence: MDSFGQPRPEDNQSVVRRMQKKYWKTKQVFIKATGKKEDEHLVASDAELDAKLEVFHSVQETCTELLKIIEKYQLRLNVISEEENELGLFLKFQAERDATQAGKMMDATGKALCSSAKQRLALCTPLSRLKQEVATFSQRAVSDTLMTINRMEQARTEYRGALLWMKDVSQELDPDTLKQMEKFRKVQMQVRNSKASFDKLKMDVCQKVDLLGASRCNMLSHSLTTYQRTLLGFWKKTARMMSQIHEACIGFHPYDFVALKQLQDTPSKISEDNKDEQIGGFLTEQLNKLVLSDEEASFESEQANKDHNEKHSQMREFGAPQFSNSENVAKDLPVDSLEGEDFEKEFSFLNNLLSSGSSSTSEFTQECQTAFGSPSASLTSQEPSMGSEPLAHSSRFLPSQLFDLGFHVAGAFNNWVSQEESELCLSHTDNQPVPSQSPKKLTRSPNNGNQDMSAWFNLFADLDPLSNPDAIGHSDDELLNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	PRPEDNQSVVRRMQK CCCCCCHHHHHHHHH	28.91	26074081
23	Phosphorylation	VRRMQKKYWKTKQVF HHHHHHHHHCCEEEE	21.12	26074081
26	Phosphorylation	MQKKYWKTKQVFIKA HHHHHHCCEEEEECC	16.74	26074081
34	Phosphorylation	KQVFIKATGKKEDEH EEEEECCCCCCCCCC	44.52	26074081
58	Phosphorylation	AKLEVFHSVQETCTE HHHHHHHHHHHHHHH	17.65	-
62	Phosphorylation	VFHSVQETCTELLKI HHHHHHHHHHHHHHH	13.98	-
64	Phosphorylation	HSVQETCTELLKIIE HHHHHHHHHHHHHHH	36.77	-
128	Phosphorylation	LALCTPLSRLKQEVA HHHCCHHHHHHHHHH	36.45	-
255	Phosphorylation	ACIGFHPYDFVALKQ HHHCCCCCCEEEHHH	17.28	28796482
266	Phosphorylation	ALKQLQDTPSKISED EHHHHCCCCCCCCCC	19.25	29396449
293	Phosphorylation	QLNKLVLSDEEASFE HHHHHHCCCHHHCCC	35.18	30266825
298	Phosphorylation	VLSDEEASFESEQAN HCCCHHHCCCHHHHC	32.59	30266825
301	Phosphorylation	DEEASFESEQANKDH CHHHCCCHHHHCCHH	32.76	26074081
324	Phosphorylation	EFGAPQFSNSENVAK HHCCCCCCCCCCHHH	33.91	-
337	Phosphorylation	AKDLPVDSLEGEDFE HHCCCCCCCCCCCHH	28.67	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ICA1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ICA1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ICA1L_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ICA1L_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.