SNX13_HUMAN - dbPTM
SNX13_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SNX13_HUMAN
UniProt AC Q9Y5W8
Protein Name Sorting nexin-13
Gene Name SNX13
Organism Homo sapiens (Human).
Sequence Length 968
Subcellular Localization Early endosome membrane
Peripheral membrane protein
Cytoplasmic side .
Protein Description May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas..
Protein Sequence MLTEASLSIWGWGSLGIVLFLITFGPFVIFYLTFYILCFVGGGLVVTLLFGKTNSEKYLEQCEHSFLPPTSPGVPKCLEEMKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLRVFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGILLPLINQLSDPDYINQYVIWMIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQRLQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQTKGLLRAAAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDGDGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTVYADYDPYAVAGVCNDHGKTYALYAITVHRRNLNSEEMWKTYRRYSDFHDFHMRITEQFESLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLAPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNSMRNVSNAVKSLPDSLAEGMTKMSDNMGKMSERLGQDIKQSFFKVPPLIPKTDSDPEHRRVSAQLDDNVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNLLQQLIRATYGDTINRKIVDHVDWMTSPEQVADSVKRFRDAFWPNGILAEAVPCRDKSIRMRTRVAGKTKLLAIMPDELKHIIGAETTRKGILRVFEMFQHNQLNRRMVYVFLEGFLETLFPQYKFRELFNKLHSRSKQMQKYKQKLQTTQAPSLQKR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
149UbiquitinationIQFATRSKEIDWQPY
HHHHHCCCCCCCCCC		56.23-
319O-linked_GlycosylationEELQYLRSLDTAGDD
HHHHHHHHHCCCCCC		28.1829351928
322O-linked_GlycosylationQYLRSLDTAGDDINT
HHHHHHCCCCCCHHH		37.5229351928
331 (in isoform 2)Ubiquitination-40.5421906983
331UbiquitinationGDDINTIKNQINSLL
CCCHHHHHHHHHHHH		40.5421906983
353PhosphorylationSRIQRLQSGKEINTV
HHHHHHHCCCCCCHH		57.3219690332
359PhosphorylationQSGKEINTVKLAANF
HCCCCCCHHHHHHHC		25.3624260401
379 (in isoform 1)Ubiquitination-4.8521906983
431PhosphorylationQRDGKHQTNQTKGLL
CCCCCCCCHHHHHHH		29.0730266825
434PhosphorylationGKHQTNQTKGLLRAA
CCCCCHHHHHHHHHH		29.2030266825
453 (in isoform 2)Ubiquitination-51.2721906983
453UbiquitinationYEQYLSEKASPRVTV
HHHHHCCCCCCCCCH		51.2721906983
490PhosphorylationDDIQRKVYELMLRDE
HHHHHHHHHHHHCCC		13.3325884760
501 (in isoform 1)Ubiquitination-25.0421906983
523PhosphorylationLDMLKDPSFRGSDDG
HHCCCCCCCCCCCCC		37.4029255136
603PhosphorylationVHRRNLNSEEMWKTY
EECCCCCHHHHHHHH		37.7924719451
613PhosphorylationMWKTYRRYSDFHDFH
HHHHHHHHHCCHHHH		12.0023927012
614PhosphorylationWKTYRRYSDFHDFHM
HHHHHHHHCCHHHHH		31.8023927012
632PhosphorylationEQFESLSSILKLPGK
HHHHCHHHHHCCCCC		36.9122210691
643 (in isoform 2)Ubiquitination-48.4221906983
644 (in isoform 2)Ubiquitination-29.5521906983
654UbiquitinationRDFLEKRKKDLNAYL
HHHHHHHHHHHHHHH		62.8021906983
655UbiquitinationDFLEKRKKDLNAYLQ
HHHHHHHHHHHHHHH		72.052190698
679PhosphorylationASPALAHYVYDFLEN
HCHHHHHHHHHHHHH		8.6320736484
681PhosphorylationPALAHYVYDFLENKA
HHHHHHHHHHHHHCH		8.2020736484
691 (in isoform 1)Ubiquitination-52.5521906983
692 (in isoform 1)Ubiquitination-32.9821906983
710PhosphorylationFVNPLRNSMRNVSNA
HHHHHHHHHHHHHHH		16.8223186163
715PhosphorylationRNSMRNVSNAVKSLP
HHHHHHHHHHHHHCC		23.71-
720PhosphorylationNVSNAVKSLPDSLAE
HHHHHHHHCCHHHHH		38.24-
750PhosphorylationLGQDIKQSFFKVPPL
HCHHHHHHHCCCCCC		27.8728857561
760PhosphorylationKVPPLIPKTDSDPEH
CCCCCCCCCCCCHHH		58.9527251275
771PhosphorylationDPEHRRVSAQLDDNV
CHHHHHHHHCCCCCC		14.4229507054
844PhosphorylationSPEQVADSVKRFRDA
CHHHHHHHHHHHHHH		21.5727050516
953PhosphorylationRSKQMQKYKQKLQTT
HHHHHHHHHHHHHHC		11.19-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SNX13_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SNX13_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SNX13_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GNAS3_HUMANGNASphysical
11729322
GNAS2_HUMANGNASphysical
11729322
ALEX_HUMANGNASphysical
11729322
GNAS1_HUMANGNASphysical
11729322
TYDP2_HUMANTDP2physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SNX13_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-359, AND MASSSPECTROMETRY.

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