dbPTM

NR1H4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NR1H4_HUMAN
UniProt AC	Q96RI1
Protein Name	Bile acid receptor
Gene Name	NR1H4
Organism	Homo sapiens (Human).
Sequence Length	486
Subcellular Localization	Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus .
Protein Description	Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. [PubMed: 10334992]
Protein Sequence	MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	GFFMEMMSMKPAKGV CHHHHHHCCCCCCCC	23.50	24719451
62 (in isoform 1)	O-linked_Glycosylation	-	5.22	24037988
132	Sumoylation	GASAGRIKGDELCVV CCCCCCCCCCEEEEE	59.97	23546875
135	Phosphorylation	AGRIKGDELCVVCGD CCCCCCCEEEEEECC	53.38	18755856
145	Phosphorylation	VVCGDRASGYHYNAL EEECCCCCCCCCEEE	40.55	18755856
154	Phosphorylation	YHYNALTCEGCKGFF CCCEEEECCCCCHHH	4.38	18755856
164	Phosphorylation	CKGFFRRSITKNAVY CCHHHHCCCCCCCEE	30.28	18755856
167	Acetylation	FFRRSITKNAVYKCK HHHCCCCCCCEEECC	41.04	22345554
210	Methylation	LAECMYTGLLTEIQC HHHHHHHHHHHHHHH	10.95	22345554
220	Methylation	TEIQCKSKRLRKNVK HHHHHCHHHHHHHHH	40.73	22345554
227	Acetylation	KRLRKNVKQHADQTV HHHHHHHHHHHHHCC	45.84	18668687
289	Sumoylation	EITNKILKEEFSAEE HHHHHHHHHHCCHHH	59.68	23546875
356	Phosphorylation	IFNKKLPSGHSDLLE HHHCCCCCCCHHHHH	60.62	23403867
359	Phosphorylation	KKLPSGHSDLLEERI CCCCCCCHHHHHHHH	33.22	23403867
369	Phosphorylation	LEERIRNSGISDEYI HHHHHHHCCCCCHHH	27.88	-
372	Phosphorylation	RIRNSGISDEYITPM HHHHCCCCCHHHHHH	28.10	-
456	Phosphorylation	GRLTELRTFNHHHAE HHHHHCCCCCHHHHH	41.22	23462506
467	Phosphorylation	HHAEMLMSWRVNDHK HHHHHHHHEEECCCC	14.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
77	Y	Phosphorylation	Kinase	SRC	P12931	PSP
145	S	Phosphorylation	Kinase	PRKCA	P17252	Uniprot
164	S	Phosphorylation	Kinase	PRKCA	P17252	Uniprot
456	T	Phosphorylation	Kinase	PRKCZ	Q05513	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
227	K	Acetylation		19883617
Lys-227 as is the major acetylation site for EP300; the dynamicly regulated acetylation inhibits heterodimerization with RXRA and transactivation activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NR1H4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOA1_HUMAN	NCOA1	physical	11136553
RXRA_HUMAN	RXRA	physical	7760852
PRKDC_HUMAN	PRKDC	physical	19833092
XRCC6_HUMAN	XRCC6	physical	19833092
XRCC5_HUMAN	XRCC5	physical	19833092
ANM1_HUMAN	PRMT1	physical	15911693
H31_HUMAN	HIST1H3A	physical	15471871
RXRA_HUMAN	RXRA	physical	19883617
G3P_HUMAN	GAPDH	physical	15604093
RXRG_HUMAN	RXRG	physical	15604093
ESR1_HUMAN	ESR1	physical	17333335
NCOR2_HUMAN	NCOR2	physical	16219912
SUMO1_HUMAN	SUMO1	physical	23546875
RXRB_HUMAN	RXRB	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB06777	Chenodeoxycholic acid

Regulatory Network of NR1H4_HUMAN

Related Literatures of Post-Translational Modification