DKK3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DKK3_HUMAN
• UniProt AC: Q9UBP4
• Protein Name: Dickkopf-related protein 3
• Gene Name: DKK3
• Organism: Homo sapiens (Human).
• Sequence Length: 350
• Subcellular Localization: Secreted.
• Protein Description: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)..
• Protein Sequence: MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMEDTQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILLPREVPDEYEVGSFMEEVRQELEDLERSLTEEMALREPAAAAAALLGGEEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	O-linked_Glycosylation	TAPAPAPTATSAPVK CCCCCCCCCCCCCCC	44.68	23234360
28	O-linked_Glycosylation	PAPAPTATSAPVKPG CCCCCCCCCCCCCCC	28.09	23234360
39	O-linked_Glycosylation	VKPGPALSYPQEEAT CCCCCCCCCCHHHHH	36.55	OGP
96	N-linked_Glycosylation	NLPPSYHNETNTDTK CCCCCCCCCCCCCCC	49.94	UniProtKB CARBOHYD
106	N-linked_Glycosylation	NTDTKVGNNTIHVHR CCCCCCCCCEEEEEC	45.52	UniProtKB CARBOHYD
119	Phosphorylation	HREIHKITNNQTGQM ECEEEECCCCCCCCE	32.68	-
121	N-linked_Glycosylation	EIHKITNNQTGQMVF EEEECCCCCCCCEEE	31.94	UniProtKB CARBOHYD
129	Phosphorylation	QTGQMVFSETVITSV CCCCEEEEEEEEEEC	22.43	-
204	N-linked_Glycosylation	KMATRGSNGTICDNQ EEEECCCCCCCCCCC	55.22	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DKK3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DKK3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DKK3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL40_HUMAN	UBA52	physical	28514442
MYO5B_HUMAN	MYO5B	physical	28514442
TNIP2_HUMAN	TNIP2	physical	28514442
CP131_HUMAN	CEP131	physical	28514442
ATD3C_HUMAN	ATAD3C	physical	28514442
MYO5A_HUMAN	MYO5A	physical	28514442
GOSR2_HUMAN	GOSR2	physical	28514442
ASPM_HUMAN	ASPM	physical	28514442
MYO5C_HUMAN	MYO5C	physical	28514442
ABCBA_HUMAN	ABCB10	physical	28514442
SMOC1_HUMAN	SMOC1	physical	28514442
LONP2_HUMAN	LONP2	physical	28514442
GDF11_HUMAN	GDF11	physical	28514442
INHBE_HUMAN	INHBE	physical	28514442
GOGA2_HUMAN	GOLGA2	physical	28514442
SENP5_HUMAN	SENP5	physical	28514442
GDC_HUMAN	SLC25A16	physical	28514442
SULF2_HUMAN	SULF2	physical	28514442
AT5F1_HUMAN	ATP5F1	physical	28514442
MYO1D_HUMAN	MYO1D	physical	28514442
ATS1_HUMAN	ADAMTS1	physical	28514442
ATP8_HUMAN	ATP8	physical	28514442
PCOC2_HUMAN	PCOLCE2	physical	28514442
GORS1_HUMAN	GORASP1	physical	28514442
ATPO_HUMAN	ATP5O	physical	28514442
LAMA5_HUMAN	LAMA5	physical	28514442
NDKM_HUMAN	NME4	physical	28514442
ADT3_HUMAN	SLC25A6	physical	28514442
TIMP3_HUMAN	TIMP3	physical	28514442
MA7D1_HUMAN	MAP7D1	physical	28514442
GSK3B_HUMAN	GSK3B	physical	28514442
GSLG1_HUMAN	GLG1	physical	28514442
ADT2_HUMAN	SLC25A5	physical	28514442
CHSTC_HUMAN	CHST12	physical	28514442
SRBP2_HUMAN	SREBF2	physical	28514442
ATP5H_HUMAN	ATP5H	physical	28514442
STX5_HUMAN	STX5	physical	28514442
PCM1_HUMAN	PCM1	physical	28514442
IFFO1_HUMAN	IFFO1	physical	28514442
MYO1B_HUMAN	MYO1B	physical	28514442
ALMS1_HUMAN	ALMS1	physical	28514442
RS3_HUMAN	RPS3	physical	28514442
GFPT2_HUMAN	GFPT2	physical	28514442
RT12_HUMAN	MRPS12	physical	28514442
DJC30_HUMAN	DNAJC30	physical	28514442
MYO9B_HUMAN	MYO9B	physical	28514442
TTF2_HUMAN	TTF2	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.