| UniProt ID | PCOC2_HUMAN | |
|---|---|---|
| UniProt AC | Q9UKZ9 | |
| Protein Name | Procollagen C-endopeptidase enhancer 2 | |
| Gene Name | PCOLCE2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 415 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.. | |
| Protein Sequence | MRGANAWAPLCLLLAAATQLSRQQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKKLPTTTEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARLTVVCKQCPLLRRGLNYIIMGQVGEDGRGKIMPNSFIMMFKTKNQKLLDALKNKQC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 64 | Phosphorylation | SKCTWKITVPEGKVV CCEEEEEEECCCEEE | 26.70 | - | |
| 82 | Phosphorylation | FRFIDLESDNLCRYD EEEEECCCCCEECEE | 38.81 | 22817900 | |
| 117 | Phosphorylation | FRPGALVSSGNKMMV CCCCCEEECCCEEEE | 33.12 | 24275569 | |
| 118 | Phosphorylation | RPGALVSSGNKMMVQ CCCCEEECCCEEEEE | 38.62 | 24275569 | |
| 128 | Phosphorylation | KMMVQMISDANTAGN EEEEEECCCCCCCCC | 25.90 | 24275569 | |
| 132 | Phosphorylation | QMISDANTAGNGFMA EECCCCCCCCCCEEE | 37.35 | 24275569 | |
| 153 | Phosphorylation | PNERGDQYCGGLLDR CCCCCCCCCCCCCCC | 9.59 | 24719451 | |
| 164 | Phosphorylation | LLDRPSGSFKTPNWP CCCCCCCCCCCCCCC | 28.10 | 24719451 | |
| 210 | Phosphorylation | ERDNYCRYDYVAVFN CCCCCCCCEEEEEEC | 14.20 | - | |
| 212 | Phosphorylation | DNYCRYDYVAVFNGG CCCCCCEEEEEECCC | 4.95 | - | |
| 293 | O-linked_Glycosylation | VTTGLKPTVALCQQK CCCCCCCHHHHHHHH | 19.47 | OGP | |
| 331 | Phosphorylation | TTITRDGSLHATVSI EEEECCCCEEEEEEE | 22.67 | 18491316 | |
| 337 | Phosphorylation | GSLHATVSIINIYKE CCEEEEEEEEEEEEC | 17.25 | 18491316 | |
| 355 | N-linked_Glycosylation | AIQQAGKNMSARLTV EEECCCCCHHHHEEE | 28.82 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCOC2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCOC2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCOC2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| STRN4_HUMAN | STRN4 | physical | 26186194 | |
| ZWINT_HUMAN | ZWINT | physical | 26186194 | |
| STRN3_HUMAN | STRN3 | physical | 26186194 | |
| STRN_HUMAN | STRN | physical | 26186194 | |
| ZWINT_HUMAN | ZWINT | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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