ARI5A_HUMAN - dbPTM
ARI5A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARI5A_HUMAN
UniProt AC Q03989
Protein Name AT-rich interactive domain-containing protein 5A
Gene Name ARID5A
Organism Homo sapiens (Human).
Sequence Length 594
Subcellular Localization Nucleus .
Protein Description Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison. [PubMed: 8649988 May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors]
Protein Sequence MAAPVKGNRKQSTEGDALDPPASPKPAGKQNGIQNPISLEDSPEAGGEREEEQEREEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPTSKPRKQYKMAKENRGDDGATERPKKAKEERRMDQMMPGKTKADAADPAPLPSQEPPRNSTEQQGLASGSSVSFVGASGCPEAYKRLLSSFYCKGTHGIMSPLAKKKLLAQVSKVEALQCQEEGCRHGAEPQASPAVHLPESPQSPKGLTENSRHRLTPQEGLQAPGGSLREEAQAGPCPAAPIFKGCFYTHPTEVLKPVSQHPRDFFSRLKDGVLLGPPGKEGLSVKEPQLVWGGDANRPSAFHKGGSRKGILYPKPKACWVSPMAKVPAESPTLPPTFPSSPGLGSKRSLEEEGAAHSGKRLRAVSPFLKEADAKKCGAKPAGSGLVSCLLGPALGPVPPEAYRGTMLHCPLNFTGTPGPLKGQAALPFSPLVIPAFPAHFLATAGPSPMAAGLMHFPPTSFDSALRHRLCPASSAWHAPPVTTYAAPHFFHLNTKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationVKGNRKQSTEGDALD
CCCCCCCCCCCCCCC		31.3126657352
13PhosphorylationKGNRKQSTEGDALDP
CCCCCCCCCCCCCCC		41.3020363803
17UbiquitinationKQSTEGDALDPPASP
CCCCCCCCCCCCCCC		25.4021890473
17UbiquitinationKQSTEGDALDPPASP
CCCCCCCCCCCCCCC		25.4021890473
23UbiquitinationDALDPPASPKPAGKQ
CCCCCCCCCCCCCCC		38.95-
23PhosphorylationDALDPPASPKPAGKQ
CCCCCCCCCCCCCCC		38.9520363803
23UbiquitinationDALDPPASPKPAGKQ
CCCCCCCCCCCCCCC		38.9523000965
85UbiquitinationRVPHLGFKQINLWKI
HCCCCCCCHHCHHHH		48.7723000965
91UbiquitinationFKQINLWKIYKAVEK
CCHHCHHHHHHHHHH		39.0523000965
93PhosphorylationQINLWKIYKAVEKLG
HHCHHHHHHHHHHHC		6.8122617229
95UbiquitinationNLWKIYKAVEKLGAY
CHHHHHHHHHHHCCC		9.5721890473
101UbiquitinationKAVEKLGAYELVTGR
HHHHHHCCCCHHHCC		12.6923000965
106PhosphorylationLGAYELVTGRRLWKN
HCCCCHHHCCCHHHH		37.2824719451
115PhosphorylationRRLWKNVYDELGGSP
CCHHHHHHHHHCCCC		17.0630108239
121PhosphorylationVYDELGGSPGSTSAA
HHHHHCCCCCCCHHH		25.0430108239
124PhosphorylationELGGSPGSTSAATCT
HHCCCCCCCHHHHHH		23.6730108239
125PhosphorylationLGGSPGSTSAATCTR
HCCCCCCCHHHHHHH		28.4430108239
126PhosphorylationGGSPGSTSAATCTRR
CCCCCCCHHHHHHHH		20.0130108239
129PhosphorylationPGSTSAATCTRRHYE
CCCCHHHHHHHHHHH		17.7130108239
161UbiquitinationLPTSKPRKQYKMAKE
CCCCCCHHHHHHHHH		67.51-
167UbiquitinationRKQYKMAKENRGDDG
HHHHHHHHHHCCCCC		52.61-
201UbiquitinationGKTKADAADPAPLPS
CCCHHHCCCCCCCCC		24.70-
201UbiquitinationGKTKADAADPAPLPS
CCCHHHCCCCCCCCC		24.7029967540
215PhosphorylationSQEPPRNSTEQQGLA
CCCCCCCCCCCCCCC		34.30-
223PhosphorylationTEQQGLASGSSVSFV
CCCCCCCCCCCEEEE		44.2221712546
226PhosphorylationQGLASGSSVSFVGAS
CCCCCCCCEEEECCC		25.88-
228PhosphorylationLASGSSVSFVGASGC
CCCCCCEEEECCCCC		19.03-
239PhosphorylationASGCPEAYKRLLSSF
CCCCHHHHHHHHHHH		8.5921712546
256PhosphorylationKGTHGIMSPLAKKKL
CCCCCCCCHHHHHHH		18.1625159151
269UbiquitinationKLLAQVSKVEALQCQ
HHHHHHHHHHHHHHH		45.2829967540
269SumoylationKLLAQVSKVEALQCQ
HHHHHHHHHHHHHHH		45.28-
269SumoylationKLLAQVSKVEALQCQ
HHHHHHHHHHHHHHH		45.28-
289PhosphorylationHGAEPQASPAVHLPE
CCCCCCCCCCCCCCC		14.2427080861
297PhosphorylationPAVHLPESPQSPKGL
CCCCCCCCCCCCCCC		26.7120164059
300PhosphorylationHLPESPQSPKGLTEN
CCCCCCCCCCCCCCC		31.7820164059
309UbiquitinationKGLTENSRHRLTPQE
CCCCCCCCCCCCCCC		30.4429967540
313PhosphorylationENSRHRLTPQEGLQA
CCCCCCCCCCCCCCC		23.9228985074
322UbiquitinationQEGLQAPGGSLREEA
CCCCCCCCCCHHHHH		41.1429967540
323UbiquitinationEGLQAPGGSLREEAQ
CCCCCCCCCHHHHHH		23.5829967540
324PhosphorylationGLQAPGGSLREEAQA
CCCCCCCCHHHHHHC		30.12-
346UbiquitinationIFKGCFYTHPTEVLK
CCCCCCCCCCCCCCC		10.9229967540
377UbiquitinationVLLGPPGKEGLSVKE
EEECCCCCCCCCCCC		55.1529967540
383UbiquitinationGKEGLSVKEPQLVWG
CCCCCCCCCCCEECC		61.37-
389UbiquitinationVKEPQLVWGGDANRP
CCCCCEECCCCCCCC		17.40-
406AcetylationFHKGGSRKGILYPKP
CCCCCCCCCCCCCCC		52.5812432429
412AcetylationRKGILYPKPKACWVS
CCCCCCCCCCCEEEC		45.6612432437
414UbiquitinationGILYPKPKACWVSPM
CCCCCCCCCEEECCC		63.4029967540
428PhosphorylationMAKVPAESPTLPPTF
CCCCCCCCCCCCCCC		25.87-
430PhosphorylationKVPAESPTLPPTFPS
CCCCCCCCCCCCCCC		62.26-
430UbiquitinationKVPAESPTLPPTFPS
CCCCCCCCCCCCCCC		62.2629967540
431UbiquitinationVPAESPTLPPTFPSS
CCCCCCCCCCCCCCC		5.6229967540
434PhosphorylationESPTLPPTFPSSPGL
CCCCCCCCCCCCCCC		46.36-
437PhosphorylationTLPPTFPSSPGLGSK
CCCCCCCCCCCCCCC		45.00-
438PhosphorylationLPPTFPSSPGLGSKR
CCCCCCCCCCCCCCC		24.19-
443PhosphorylationPSSPGLGSKRSLEEE
CCCCCCCCCCCHHHH		29.91-
457UbiquitinationEGAAHSGKRLRAVSP
HCCCCCCHHHHHHCH		51.80-
463PhosphorylationGKRLRAVSPFLKEAD
CHHHHHHCHHHHHHH		14.6730266825
467UbiquitinationRAVSPFLKEADAKKC
HHHCHHHHHHHHHHC		51.7629967540
468UbiquitinationAVSPFLKEADAKKCG
HHCHHHHHHHHHHCC		54.6629967540
580PhosphorylationAWHAPPVTTYAAPHF
CCCCCCCCCCCCCCE		21.62-
581PhosphorylationWHAPPVTTYAAPHFF
CCCCCCCCCCCCCEE		16.05-
582PhosphorylationHAPPVTTYAAPHFFH
CCCCCCCCCCCCEEC		7.44-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARI5A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARI5A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARI5A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ESR1_HUMANESR1physical
15941852
RBPMS_HUMANRBPMSphysical
25416956
RHXF2_HUMANRHOXF2physical
25416956
K1C40_HUMANKRT40physical
25416956
KR122_HUMANKRTAP12-2physical
25416956
KR124_HUMANKRTAP12-4physical
25416956
SOX5_HUMANSOX5physical
21516116
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARI5A_HUMAN

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Related Literatures of Post-Translational Modification

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