| UniProt ID | TBRG1_HUMAN | |
|---|---|---|
| UniProt AC | Q3YBR2 | |
| Protein Name | Transforming growth factor beta regulator 1 | |
| Gene Name | TBRG1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 411 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.. | |
| Protein Sequence | MSLLDGLASSPRAPLQSSKARMKKLPKKSQNEKYRLKYLRLRKAAKATVFENAAICDEIARLEEKFLKAKEERRYLLKKLLQLQALTEGEVQAAAPSHSSSLPLTYGVASSVGTIQGAGPISGPSTGAEEPFGKKTKKEKKEKGKENNKLEVLKKTCKKKKMAGGARKLVQPIALDPSGRPVFPIGLGGLTVYSLGEIITDRPGFHDESAIYPVGYCSTRIYASMKCPDQKCLYTCQIKDGGVQPQFEIVPEDDPQNAIVSSSADACHAELLRTISTTMGKLMPNLLPAGADFFGFSHPAIHNLIQSCPGARKCINYQWVKFDVCKPGDGQLPEGLPENDAAMSFEAFQRQIFDEDQNDPLLPGSLDLPELQPAAFVSSYQPMYLTHEPLVDTHLQHLKSPSQGSPIQSSD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSLLDGLAS ------CCHHHHHCC | 37.32 | 20068231 | |
| 2 | Phosphorylation | ------MSLLDGLAS ------CCHHHHHCC | 37.32 | 23663014 | |
| 9 | Phosphorylation | SLLDGLASSPRAPLQ CHHHHHCCCCCCCCC | 46.01 | 30266825 | |
| 10 | Phosphorylation | LLDGLASSPRAPLQS HHHHHCCCCCCCCCC | 16.88 | 30266825 | |
| 10 (in isoform 2) | Phosphorylation | - | 16.88 | - | |
| 17 | Phosphorylation | SPRAPLQSSKARMKK CCCCCCCCCHHHHHH | 41.30 | 28450419 | |
| 18 | Phosphorylation | PRAPLQSSKARMKKL CCCCCCCCHHHHHHC | 19.85 | 28464451 | |
| 400 | Phosphorylation | THLQHLKSPSQGSPI HHHHHCCCCCCCCCC | 35.82 | 25159151 | |
| 402 | Phosphorylation | LQHLKSPSQGSPIQS HHHCCCCCCCCCCCC | 55.02 | 25159151 | |
| 405 | Phosphorylation | LKSPSQGSPIQSSD- CCCCCCCCCCCCCC- | 15.93 | 25159151 | |
| 409 | Phosphorylation | SQGSPIQSSD----- CCCCCCCCCC----- | 36.87 | 23090842 | |
| 410 | Phosphorylation | QGSPIQSSD------ CCCCCCCCC------ | 30.85 | 23090842 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TBRG1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TBRG1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TBRG1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MDM2_HUMAN | MDM2 | physical | 17110379 | |
| IN80E_HUMAN | INO80E | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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