| UniProt ID | FBX3_HUMAN | |
|---|---|---|
| UniProt AC | Q9UK99 | |
| Protein Name | F-box only protein 3 | |
| Gene Name | FBXO3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 471 | |
| Subcellular Localization | Nucleus. Colocalizes with PML at the peripheries of nuclear bodies. | |
| Protein Description | Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.. | |
| Protein Sequence | MAAMETETAPLTLESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKKYWLISEEEKTQKNQCWKSLFIDTYSDVGRYIDHYAAIKKAWDDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVKNVVSGGFPIIRDQIFRYVHDPECVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSKDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRVYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKIFNVAIPRFHMACPTFRVSIARLEMGPDEYEEMEEEEEEEEEEDEDDDSADMDESDEDDEEERRRRVFDVPIRRRRCSRLF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 59 | Ubiquitination | LWRRHCKKYWLISEE HHHHHHHHEEEECHH | 47.23 | - | |
| 60 | Phosphorylation | WRRHCKKYWLISEEE HHHHHHHEEEECHHH | 7.31 | 28102081 | |
| 64 | Phosphorylation | CKKYWLISEEEKTQK HHHEEEECHHHHHHH | 36.46 | 28102081 | |
| 68 | Ubiquitination | WLISEEEKTQKNQCW EEECHHHHHHHHCHH | 60.58 | - | |
| 71 | Ubiquitination | SEEEKTQKNQCWKSL CHHHHHHHHCHHHHH | 54.97 | - | |
| 76 | Ubiquitination | TQKNQCWKSLFIDTY HHHHCHHHHHHEECH | 44.93 | - | |
| 93 | Phosphorylation | VGRYIDHYAAIKKAW HHHHHHHHHHHHHHH | 8.25 | 22167270 | |
| 97 | Ubiquitination | IDHYAAIKKAWDDLK HHHHHHHHHHHHHHH | 31.54 | - | |
| 98 | Ubiquitination | DHYAAIKKAWDDLKK HHHHHHHHHHHHHHH | 48.90 | - | |
| 117 | Phosphorylation | RCPRMVLSLKEGARE CCCHHEEECCCCCCH | 26.45 | 24719451 | |
| 119 | Ubiquitination | PRMVLSLKEGAREED CHHEEECCCCCCHHH | 51.21 | 21890473 | |
| 119 | Ubiquitination | PRMVLSLKEGAREED CHHEEECCCCCCHHH | 51.21 | 21890473 | |
| 119 (in isoform 1) | Ubiquitination | - | 51.21 | 21890473 | |
| 119 (in isoform 2) | Ubiquitination | - | 51.21 | 21890473 | |
| 119 | Ubiquitination | PRMVLSLKEGAREED CHHEEECCCCCCHHH | 51.21 | 21890473 | |
| 137 | Ubiquitination | VEAQIGCKLPDDYRC HHHHHCCCCCCCCCE | 58.82 | - | |
| 153 | Ubiquitination | YRIHNGQKLVVPGLL EEEECCCEEEECCHH | 44.65 | - | |
| 166 | Phosphorylation | LLGSMALSNHYRSED HHHHHHHCCCCCCCC | 16.42 | - | |
| 218 | Ubiquitination | EAAEGRNKNEVFYQC HHHCCCCCCCCEEEC | 53.80 | - | |
| 223 | Phosphorylation | RNKNEVFYQCPDQMA CCCCCCEEECHHHHH | 17.87 | 27642862 | |
| 322 | Ubiquitination | SKDALPEKACQLDSR CCCCCCHHHHHCCHH | 53.15 | - | |
| 337 (in isoform 1) | Ubiquitination | - | 58.68 | 21890473 | |
| 337 | Ubiquitination | YWRITNAKGDVEEVQ HEEEECCCCCCEEEC | 58.68 | 21906983 | |
| 337 (in isoform 2) | Ubiquitination | - | 58.68 | 21890473 | |
| 390 (in isoform 1) | Ubiquitination | - | 50.19 | 21890473 | |
| 390 (in isoform 2) | Ubiquitination | - | 50.19 | 21890473 | |
| 390 | Ubiquitination | HFLYFKDKIFNVAIP EEEEECCCEEEEEEC | 50.19 | 21890473 | |
| 390 | Ubiquitination | HFLYFKDKIFNVAIP EEEEECCCEEEEEEC | 50.19 | 21890473 | |
| 390 | Ubiquitination | HFLYFKDKIFNVAIP EEEEECCCEEEEEEC | 50.19 | 21890473 | |
| 420 | Phosphorylation | LEMGPDEYEEMEEEE EECCHHHHHHHHHHH | 25.27 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FBX3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBX3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBX3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RBX1_HUMAN | RBX1 | physical | 18809579 | |
| CUL1_HUMAN | CUL1 | physical | 18809579 | |
| SKP1_HUMAN | SKP1 | physical | 18809579 | |
| PML_HUMAN | PML | physical | 18809579 | |
| SMUF1_HUMAN | SMURF1 | physical | 25721664 | |
| SKP1_HUMAN | SKP1 | physical | 21516116 | |
| AIRE_HUMAN | AIRE | physical | 27365398 | |
| FBX3_HUMAN | FBXO3 | physical | 28561026 | |
| SKP1_HUMAN | SKP1 | physical | 28561026 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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