UniProt ID | MECR_HUMAN | |
---|---|---|
UniProt AC | Q9BV79 | |
Protein Name | Enoyl-[acyl-carrier-protein] reductase, mitochondrial {ECO:0000305} | |
Gene Name | MECR | |
Organism | Homo sapiens (Human). | |
Sequence Length | 373 | |
Subcellular Localization |
Isoform 1: Mitochondrion . Isoform 2: Cytoplasm . Nucleus . |
|
Protein Description | Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16).. | |
Protein Sequence | MWVCSTLWRVRTPARQWRGLLPASGCHGPAASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
5 | Phosphorylation | ---MWVCSTLWRVRT ---CCCCCCEEEECC | 19.54 | - | |
6 | Phosphorylation | --MWVCSTLWRVRTP --CCCCCCEEEECCC | 25.80 | 29759185 | |
56 | Acetylation | GHHGDPAKVVELKNL CCCCCHHHEEEEECC | 52.80 | 25038526 | |
61 | Acetylation | PAKVVELKNLELAAV HHHEEEEECCEEEEE | 46.08 | 25953088 | |
61 | Succinylation | PAKVVELKNLELAAV HHHEEEEECCEEEEE | 46.08 | - | |
61 | Succinylation | PAKVVELKNLELAAV HHHEEEEECCEEEEE | 46.08 | - | |
147 | Ubiquitination | TEAVFSEEALIQVPS CEEECCCHHHEECCC | 47.80 | 24816145 | |
223 | Malonylation | RDRPDIQKLSDRLKS CCCCCHHHHHHHHHH | 50.74 | 26320211 | |
223 | Ubiquitination | RDRPDIQKLSDRLKS CCCCCHHHHHHHHHH | 50.74 | 24816145 | |
248 | Malonylation | ELRRPEMKNFFKDMP HHCCHHHHHHHHCCC | 49.28 | 26320211 | |
251 | Ubiquitination | RPEMKNFFKDMPQPR CHHHHHHHHCCCCCE | 10.29 | 24816145 | |
252 | Acetylation | PEMKNFFKDMPQPRL HHHHHHHHCCCCCEE | 49.32 | 25038526 | |
252 | Succinylation | PEMKNFFKDMPQPRL HHHHHHHHCCCCCEE | 49.32 | - | |
252 | Succinylation | PEMKNFFKDMPQPRL HHHHHHHHCCCCCEE | 49.32 | - | |
252 | Malonylation | PEMKNFFKDMPQPRL HHHHHHHHCCCCCEE | 49.32 | 26320211 | |
267 | Succinylation | ALNCVGGKSSTELLR EEECCCCHHHHHHHH | 34.99 | - | |
267 | Succinylation | ALNCVGGKSSTELLR EEECCCCHHHHHHHH | 34.99 | 27452117 | |
267 | Malonylation | ALNCVGGKSSTELLR EEECCCCHHHHHHHH | 34.99 | 26320211 | |
267 | Ubiquitination | ALNCVGGKSSTELLR EEECCCCHHHHHHHH | 34.99 | - | |
267 | Acetylation | ALNCVGGKSSTELLR EEECCCCHHHHHHHH | 34.99 | 25825284 | |
278 | Methylation | ELLRQLARGGTMVTY HHHHHHHHCCCEEEE | 53.30 | 115483091 | |
296 | Phosphorylation | AKQPVVASVSLLIFK CCCCEEEEEEEEEEE | 10.71 | 22673903 | |
298 | Phosphorylation | QPVVASVSLLIFKDL CCEEEEEEEEEEECC | 18.24 | 22673903 | |
316 | Succinylation | GFWLSQWKKDHSPDQ CCHHHHHCCCCCHHH | 40.46 | - | |
316 | Succinylation | GFWLSQWKKDHSPDQ CCHHHHHCCCCCHHH | 40.46 | - | |
317 | Succinylation | FWLSQWKKDHSPDQF CHHHHHCCCCCHHHH | 58.68 | 27452117 | |
320 | Phosphorylation | SQWKKDHSPDQFKEL HHHCCCCCHHHHHHH | 40.06 | 23828894 | |
325 | Acetylation | DHSPDQFKELILTLC CCCHHHHHHHHHHHH | 46.08 | 25038526 | |
330 | Phosphorylation | QFKELILTLCDLIRR HHHHHHHHHHHHHHC | 20.53 | 24670416 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MECR_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MECR_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MECR_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
RARA_HUMAN | RARA | physical | 9795230 | |
PPARA_MOUSE | Ppara | physical | 9795230 | |
RXRA_MOUSE | Rxra | physical | 9795230 | |
HNF4A_RAT | Hnf4a | physical | 9795230 | |
PPARA_HUMAN | PPARA | physical | 9795230 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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