MECR_HUMAN - dbPTM
MECR_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MECR_HUMAN
UniProt AC Q9BV79
Protein Name Enoyl-[acyl-carrier-protein] reductase, mitochondrial {ECO:0000305}
Gene Name MECR
Organism Homo sapiens (Human).
Sequence Length 373
Subcellular Localization Isoform 1: Mitochondrion .
Isoform 2: Cytoplasm . Nucleus .
Protein Description Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16)..
Protein Sequence MWVCSTLWRVRTPARQWRGLLPASGCHGPAASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MWVCSTLWRVRT
---CCCCCCEEEECC
19.54-
6Phosphorylation--MWVCSTLWRVRTP
--CCCCCCEEEECCC
25.8029759185
56AcetylationGHHGDPAKVVELKNL
CCCCCHHHEEEEECC
52.8025038526
61AcetylationPAKVVELKNLELAAV
HHHEEEEECCEEEEE
46.0825953088
61SuccinylationPAKVVELKNLELAAV
HHHEEEEECCEEEEE
46.08-
61SuccinylationPAKVVELKNLELAAV
HHHEEEEECCEEEEE
46.08-
147UbiquitinationTEAVFSEEALIQVPS
CEEECCCHHHEECCC
47.8024816145
223MalonylationRDRPDIQKLSDRLKS
CCCCCHHHHHHHHHH
50.7426320211
223UbiquitinationRDRPDIQKLSDRLKS
CCCCCHHHHHHHHHH
50.7424816145
248MalonylationELRRPEMKNFFKDMP
HHCCHHHHHHHHCCC
49.2826320211
251UbiquitinationRPEMKNFFKDMPQPR
CHHHHHHHHCCCCCE
10.2924816145
252AcetylationPEMKNFFKDMPQPRL
HHHHHHHHCCCCCEE
49.3225038526
252SuccinylationPEMKNFFKDMPQPRL
HHHHHHHHCCCCCEE
49.32-
252SuccinylationPEMKNFFKDMPQPRL
HHHHHHHHCCCCCEE
49.32-
252MalonylationPEMKNFFKDMPQPRL
HHHHHHHHCCCCCEE
49.3226320211
267SuccinylationALNCVGGKSSTELLR
EEECCCCHHHHHHHH
34.99-
267SuccinylationALNCVGGKSSTELLR
EEECCCCHHHHHHHH
34.9927452117
267MalonylationALNCVGGKSSTELLR
EEECCCCHHHHHHHH
34.9926320211
267UbiquitinationALNCVGGKSSTELLR
EEECCCCHHHHHHHH
34.99-
267AcetylationALNCVGGKSSTELLR
EEECCCCHHHHHHHH
34.9925825284
278MethylationELLRQLARGGTMVTY
HHHHHHHHCCCEEEE
53.30115483091
296PhosphorylationAKQPVVASVSLLIFK
CCCCEEEEEEEEEEE
10.7122673903
298PhosphorylationQPVVASVSLLIFKDL
CCEEEEEEEEEEECC
18.2422673903
316SuccinylationGFWLSQWKKDHSPDQ
CCHHHHHCCCCCHHH
40.46-
316SuccinylationGFWLSQWKKDHSPDQ
CCHHHHHCCCCCHHH
40.46-
317SuccinylationFWLSQWKKDHSPDQF
CHHHHHCCCCCHHHH
58.6827452117
320PhosphorylationSQWKKDHSPDQFKEL
HHHCCCCCHHHHHHH
40.0623828894
325AcetylationDHSPDQFKELILTLC
CCCHHHHHHHHHHHH
46.0825038526
330PhosphorylationQFKELILTLCDLIRR
HHHHHHHHHHHHHHC
20.5324670416

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MECR_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MECR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MECR_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RARA_HUMANRARAphysical
9795230
PPARA_MOUSEPparaphysical
9795230
RXRA_MOUSERxraphysical
9795230
HNF4A_RATHnf4aphysical
9795230
PPARA_HUMANPPARAphysical
9795230

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MECR_HUMAN

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Related Literatures of Post-Translational Modification

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