PPARA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPARA_MOUSE
• UniProt AC: P23204
• Protein Name: Peroxisome proliferator-activated receptor alpha
• Gene Name: Ppara
• Organism: Mus musculus (Mouse).
• Sequence Length: 468
• Subcellular Localization: Nucleus .
• Protein Description: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2..
• Protein Sequence: MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	LEADDLESPLSEEFL CCCCCCCCCCCHHHH	38.14	-
73	Phosphorylation	SVITDTLSPASSPSS CEEECCCCCCCCCCC	22.10	-
196	Ubiquitination	LTCEHDLKDSETADL EECCCCCCCCCCCCH	66.33	22790023
204	Ubiquitination	DSETADLKSLGKRIH CCCCCCHHHHHHHHH	44.15	22790023
311	Phosphorylation	DQVTLLKYGVYEAIF CHHHHHHHHHHHHHH	16.28	22871156
314	Phosphorylation	TLLKYGVYEAIFTML HHHHHHHHHHHHHHH	8.69	-
319	Phosphorylation	GVYEAIFTMLSSLMN HHHHHHHHHHHHHCC	15.87	-
322	Phosphorylation	EAIFTMLSSLMNKDG HHHHHHHHHHCCCCC	15.59	22871156
358	Sumoylation	FCDIMEPKFDFAMKF CCCCCCCCCCHHHHC	44.23	-
414	Phosphorylation	VLKLHLQSNHPDDTF HHHHHHHHCCCCCCC	43.39	30635358
420	Phosphorylation	QSNHPDDTFLFPKLL HHCCCCCCCHHHHHH	29.62	30635358
425	Ubiquitination	DDTFLFPKLLQKMVD CCCCHHHHHHHHHHH	55.27	22790023
429	Ubiquitination	LFPKLLQKMVDLRQL HHHHHHHHHHHHHHH	40.64	22790023
449	Ubiquitination	QLVQVIKKTESDAAL HHHHHHHHCCCHHHH	46.53	22790023
452	Phosphorylation	QVIKKTESDAALHPL HHHHHCCCHHHHHHH	37.47	15312046

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
73	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
280	S	Phosphorylation	Kinase	GSK3A	Q2NL51	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPARA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPARA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NR1H3_HUMAN	NR1H3	physical	8621574
RXRA_MOUSE	Rxra	physical	20211142
GATA1_CHICK	GATA1	physical	11724781
GATA2_CHICK	GATA2	physical	11724781
GATA3_CHICK	GATA3	physical	11724781
GATA3_MOUSE	Gata3	physical	11724781
GATA4_MOUSE	Gata4	physical	11724781
GATA6_MOUSE	Gata6	physical	11724781
GATA1_MOUSE	Gata1	physical	11724781
NCOR1_HUMAN	NCOR1	physical	11903058

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.