GATA3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GATA3_MOUSE
• UniProt AC: P23772
• Protein Name: Trans-acting T-cell-specific transcription factor GATA-3
• Gene Name: Gata3
• Organism: Mus musculus (Mouse).
• Sequence Length: 443
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses..
• Protein Sequence: MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLGHSYMEAQYPLTEEVDVLFNIDGQGNHVPSYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALSSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLAAGHSSPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVQLPDSMKLETSHSRGSMTTLGGASSSAHHPITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDALEDFPKSSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSGLSFGPHHPSSMVTAMG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
114	Phosphorylation	TASPWNLSPFSKTSI CCCCCCCCCCCCCCC	22.23	25266776
155	Phosphorylation	HLFTFPPTPPKDVSP CCEECCCCCCCCCCC	53.08	-
161	Phosphorylation	PTPPKDVSPDPSLST CCCCCCCCCCCCCCC	33.45	26239621
165	Phosphorylation	KDVSPDPSLSTPGSA CCCCCCCCCCCCCCC	42.19	28285833
171	Phosphorylation	PSLSTPGSAGSARQD CCCCCCCCCCCCCCC	30.57	-
257	Phosphorylation	SRPKARSSTEGRECV CCCCCCCCCCCCCCC	25.56	-
308	Phosphorylation	IKPKRRLSAARRAGT CCHHHHHHHHHHHCC	20.33	-
358	Acetylation	NRPLTMKKEGIQTRN CCCCCCCHHHHHHHH	50.80	15611599
369	Phosphorylation	QTRNRKMSSKSKKCK HHHHHHCCCCCHHHH	37.33	28059163
407	Phosphorylation	MSSLSHISPFSHSSH HHHCCCCCCCCCCCC	17.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
155	T	Phosphorylation	Kinase	CDK2	P24941	PSP
308	S	Phosphorylation	Kinase	MAPK14	P47811	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GATA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GATA3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED1_MOUSE	Med1	physical	20211142
TBX21_MOUSE	Tbx21	physical	20211142
FOXP3_MOUSE	Foxp3	physical	22922362

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.