FOXP3_MOUSE - dbPTM
FOXP3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FOXP3_MOUSE
UniProt AC Q99JB6
Protein Name Forkhead box protein P3
Gene Name Foxp3
Organism Mus musculus (Mouse).
Sequence Length 429
Subcellular Localization Nucleus . Cytoplasm . Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg) (By similarity). The 41 kDa form derived by proteolytic processing is found e
Protein Description Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. [PubMed: 15790681 Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (By similarity Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1]
Protein Sequence MPNPRPAKPMAPSLALGPSPGVLPSWKTAPKGSELLGTRGSGGPFQGRDLRSGAHTSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHFMHQLSTVDAHAQTPVLQVRPLDNPAMISLPPPSAATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKWPGCEKVFEEPEEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHLAGKMALAKAPSVASMDKSSCCIVATSTQGSVLPAWSAPREAPDGGLFAVRRHLWGSHGNSSFPEFFHNMDYFKYHNMRPPFTYATLIRWAILEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDEFEFRKKRSQRPNKCSNPCP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationPSLALGPSPGVLPSW
CCCCCCCCCCCCCCC
32.2723853094
27UbiquitinationPGVLPSWKTAPKGSE
CCCCCCCCCCCCCCC
38.86-
31AcetylationPSWKTAPKGSELLGT
CCCCCCCCCCCCCCC
73.0222312127
33O-linked_GlycosylationWKTAPKGSELLGTRG
CCCCCCCCCCCCCCC
31.0630664665
33PhosphorylationWKTAPKGSELLGTRG
CCCCCCCCCCCCCCC
31.06-
38O-linked_GlycosylationKGSELLGTRGSGGPF
CCCCCCCCCCCCCCC
31.6530664665
41PhosphorylationELLGTRGSGGPFQGR
CCCCCCCCCCCCCCC
36.97-
57O-linked_GlycosylationLRSGAHTSSSLNPLP
CCCCCCCCCCCCCCC
14.2030664665
58O-linked_GlycosylationRSGAHTSSSLNPLPP
CCCCCCCCCCCCCCH
39.7530664665
59O-linked_GlycosylationSGAHTSSSLNPLPPS
CCCCCCCCCCCCCHH
31.7530664665
72O-linked_GlycosylationPSQLQLPTVPLVMVA
HHHCCCCCCCEEEEC
43.2630664665
175PhosphorylationCTFPRSGTPRKDSNL
EECCCCCCCCCCCCC
22.5923853094
249UbiquitinationEQQLELEKEKLGAMQ
HHHHHHHHHHHHHHH
73.1623973222
251UbiquitinationQLELEKEKLGAMQAH
HHHHHHHHHHHHHHH
64.3923973222
262UbiquitinationMQAHLAGKMALAKAP
HHHHHHHHHHHHCCC
18.5223973222
262AcetylationMQAHLAGKMALAKAP
HHHHHHHHHHHHCCC
18.5222312127
267UbiquitinationAGKMALAKAPSVASM
HHHHHHHCCCCCHHC
62.7823973222
267AcetylationAGKMALAKAPSVASM
HHHHHHHCCCCCHHC
62.7822312127
270O-linked_GlycosylationMALAKAPSVASMDKS
HHHHCCCCCHHCCCC
34.8630664665
273O-linked_GlycosylationAKAPSVASMDKSSCC
HCCCCCHHCCCCCCE
25.9230664665
285O-linked_GlycosylationSCCIVATSTQGSVLP
CCEEEEECCCCCEEE
14.7030664665
286O-linked_GlycosylationCCIVATSTQGSVLPA
CEEEEECCCCCEEEC
32.3730664665
393UbiquitinationRHNLSLHKCFVRVES
HHHCEEEEEEEEEEC
34.3623973222
418PhosphorylationFEFRKKRSQRPNKCS
HHHHHHHCCCCCCCC
39.15-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
19SPhosphorylationKinaseCDK2P24941
PSP
19SPhosphorylationKinaseCDK2P97377
Uniprot
33SPhosphorylationKinasePIM2Q9P1W9
PSP
41SPhosphorylationKinasePIM2Q9P1W9
PSP
175TPhosphorylationKinaseCDK2P24941
PSP
175TPhosphorylationKinaseCDK2P97377
Uniprot

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
418SPhosphorylation

23853094

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FOXP3_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KAT5_MOUSEKat5physical
22579476
EP300_MOUSEEp300physical
22579476
HDAC7_MOUSEHdac7physical
22579476
IKZF4_MOUSEIkzf4physical
22579476
RL40_MOUSEUba52physical
22579476
VIR_MOUSE1110037F02Rikphysical
22922362
TRM1L_MOUSETrmt1lphysical
22922362
NCBP3_MOUSE1200014J11Rikphysical
22922362
PPR18_MOUSEPpp1r18physical
22922362
CS047_MOUSE2310022A10Rikphysical
22922362
CCAR2_MOUSECcar2physical
22922362
I2BPL_MOUSEIrf2bplphysical
22922362
AAK1_MOUSEAak1physical
22922362
AATF_MOUSEAatfphysical
22922362
ACACB_MOUSEAcacbphysical
22922362
ACINU_MOUSEAcin1physical
22922362
ACSL4_MOUSEAcsl4physical
22922362
DSRAD_MOUSEAdarphysical
22922362
ADDA_MOUSEAdd1physical
22922362
ADDG_MOUSEAdd3physical
22922362
PUR8_MOUSEAdslphysical
22922362
ELYS_MOUSEAhctf1physical
22922362
APC7_MOUSEAnapc7physical
22922362
AP1B1_MOUSEAp1b1physical
22922362
AP2A1_MOUSEAp2a1physical
22922362
AP2B1_MOUSEAp2b1physical
22922362
AP3S1_MOUSEAp3s1physical
22922362
APLF_MOUSEAplfphysical
22922362
COPD_MOUSEArcn1physical
22922362
ARFG2_MOUSEArfgap2physical
22922362
ARHG1_MOUSEArhgef1physical
22922362
ARHG6_MOUSEArhgef6physical
22922362
ARI1A_MOUSEArid1aphysical
22922362
ARI1_MOUSEArih1physical
22922362
ARC1B_MOUSEArpc1bphysical
22922362
ASH2L_MOUSEAsh2lphysical
22922362
ATAD5_MOUSEAtad5physical
22922362
ATM_MOUSEAtmphysical
22922362
ATX2_MOUSEAtxn2physical
22922362
PRC2A_MOUSEPrrc2aphysical
22922362
BAX_MOUSEBaxphysical
22922362
BC11B_MOUSEBcl11bphysical
22922362
BCL7A_MOUSEBcl7aphysical
22922362
BCL7C_MOUSEBcl7cphysical
22922362
BCLF1_MOUSEBclaf1physical
22922362
BOP1_MOUSEBop1physical
22922362
BRD7_MOUSEBrd7physical
22922362
BABA2_MOUSEBrephysical
22922362
PYR1_MOUSECadphysical
22922362
KCC2D_MOUSECamk2dphysical
22922362
PEBB_MOUSECbfbphysical
22922362
CBX4_MOUSECbx4physical
22922362
SGF29_MOUSECcdc101physical
22922362
CC137_MOUSECcdc137physical
22922362
CCNB1_MOUSECcnb1physical
22922362
TCPD_MOUSECct4physical
22922362
CD2AP_MOUSECd2apphysical
22922362
CD2B2_MOUSECd2bp2physical
22922362
CD11B_MOUSECdk11bphysical
22922362
CDC5L_MOUSECdc5lphysical
22922362
CDA7L_MOUSECdca7lphysical
22922362
CDK6_MOUSECdk6physical
22922362
CEBPZ_MOUSECebpzphysical
22922362
CENPQ_MOUSECenpqphysical
22922362
CHD1L_MOUSEChd1lphysical
22922362
CHD4_MOUSEChd4physical
22922362
CHD8_MOUSEChd8physical
22922362
CKAP5_MOUSECkap5physical
22922362
CLAP2_MOUSEClasp2physical
22922362
CLK3_MOUSEClk3physical
22922362
CNN3_MOUSECnn3physical
22922362
CNOT3_MOUSECnot3physical
22922362
COPB_MOUSECopb1physical
22922362
COPB2_MOUSECopb2physical
22922362
COPG2_MOUSECopg2physical
22922362
COR1A_MOUSECoro1aphysical
22922362
COR1C_MOUSECoro1cphysical
22922362
XPO2_MOUSECse1lphysical
22922362
KC1D_MOUSECsnk1dphysical
22922362
PYRG1_MOUSECtpsphysical
22922362
CUL3_MOUSECul3physical
22922362
SKAP_MOUSEKnstrnphysical
22922362
SYDC_MOUSEDarsphysical
22922362
DBNL_MOUSEDbnlphysical
22922362
ODB2_MOUSEDbtphysical
22922362
DD19A_MOUSEDdx19aphysical
22922362
DDX41_MOUSEDdx41physical
22922362
DDX49_MOUSEDdx49physical
22922362
DDX51_MOUSEDdx51physical
22922362
DDX56_MOUSEDdx56physical
22922362
DEOC_MOUSEDeraphysical
22922362
DHX30_MOUSEDhx30physical
22922362
DHX36_MOUSEDhx36physical
22922362
DMAP1_MOUSEDmap1physical
22922362
DNJB6_MOUSEDnajb6physical
22922362
DNM1L_MOUSEDnm1lphysical
22922362
DYN2_MOUSEDnm2physical
22922362
REQU_MOUSEDpf2physical
22922362
DPY30_MOUSEDpy30physical
22922362
DYHC1_MOUSEDync1h1physical
22922362
DC1L1_MOUSEDync1li1physical
22922362
IF2B_MOUSEEif2s2physical
22922362
IF4G1_MOUSEEif4g1physical
22922362
IF4G3_MOUSEEif4g3physical
22922362
ELF1_MOUSEElf1physical
22922362
ELF4_MOUSEElf4physical
22922362
ERCC3_MOUSEErcc3physical
22922362
ETV3_MOUSEEtv3physical
22922362
EXOS1_MOUSEExosc1physical
22922362
EXOS5_MOUSEExosc5physical
22922362
EXOS7_MOUSEExosc7physical
22922362
SKA3_MOUSESka3physical
22922362
NIBAN_MOUSEFam129aphysical
22922362
FA76A_MOUSEFam76aphysical
22922362
FA98A_MOUSEFam98aphysical
22922362
FA98B_MOUSEFam98bphysical
22922362
FAS_MOUSEFasnphysical
22922362
FBX28_MOUSEFbxo28physical
22922362
FMNL1_MOUSEFmnl1physical
22922362
FOXP1_MOUSEFoxp1physical
22922362
FOXP4_MOUSEFoxp4physical
22922362
SPB1_MOUSEFtsj3physical
22922362
FYB1_MOUSEFybphysical
22922362
UIF_MOUSEFyttd1physical
22922362
GA2L3_MOUSEGas2l3physical
22922362
GATA3_MOUSEGata3physical
22922362
P66A_MOUSEGatad2aphysical
22922362
GIT2_MOUSEGit2physical
22922362
GUAA_MOUSEGmpsphysical
22922362
NOG2_MOUSEGnl2physical
22922362
GPTC4_MOUSEGpatch4physical
22922362
GSK3B_MOUSEGsk3bphysical
22922362
GELS_MOUSEGsnphysical
22922362
ERF3A_MOUSEGspt1physical
22922362
TF2B_MOUSEGtf2bphysical
22922362
T2EA_MOUSEGtf2e1physical
22922362
TF3C1_MOUSEGtf3c1physical
22922362
TF3C2_MOUSEGtf3c2physical
22922362
TF3C5_MOUSEGtf3c5physical
22922362
NOG1_MOUSEGtpbp4physical
22922362
GTSE1_MOUSEGtse1physical
22922362
H10_MOUSEH1f0physical
22922362
H2AX_MOUSEH2afxphysical
22922362
HAUS4_MOUSEHaus4physical
22922362
HDAC1_MOUSEHdac1physical
22922362
HDAC2_MOUSEHdac2physical
22922362
HELZ_MOUSEHelzphysical
22922362
HXK2_MOUSEHk2physical
22922362
HNRPL_MOUSEHnrnplphysical
22922362
HNRLL_MOUSEHnrnpllphysical
22922362
IF2B3_MOUSEIgf2bp3physical
22922362
RED_MOUSEIkphysical
22922362
IKZF3_MOUSEIkzf3physical
22922362
IMP4_MOUSEImp4physical
22922362
SHIP1_MOUSEInpp5dphysical
22922362
INT10_MOUSEInts10physical
22922362
INT3_MOUSEInts3physical
22922362
INT6_MOUSEInts6physical
22922362
IQGA1_MOUSEIqgap1physical
22922362
I20L2_MOUSEIsg20l2physical
22922362
KDM1A_MOUSEKdm1aphysical
22922362
KIF11_MOUSEKif11physical
22922362
KI20B_MOUSEKif20bphysical
22922362
KIF4_MOUSEKif4physical
22922362
IMA4_MOUSEKpna3physical
22922362
KRIT1_MOUSEKrit1physical
22922362
LAS1L_MOUSELas1lphysical
22922362
LAT_MOUSELatphysical
22922362
PLSL_MOUSELcp1physical
22922362
ARH_MOUSELdlrap1physical
22922362
LENG8_MOUSELeng8physical
22922362
LIMS1_MOUSELims1physical
22922362
LPXN_MOUSELpxnphysical
22922362
LRC40_MOUSELrrc40physical
22922362
LUC7L_MOUSELuc7lphysical
22922362
MD2L1_MOUSEMad2l1physical
22922362
MAK16_MOUSEMak16physical
22922362
MP2K1_MOUSEMap2k1physical
22922362
MP2K2_MOUSEMap2k2physical
22922362
MP2K7_MOUSEMap2k7physical
22922362
MARE2_MOUSEMapre2physical
22922362
MARK2_MOUSEMark2physical
22922362
MBNL1_MOUSEMbnl1physical
22922362
MCM10_MOUSEMcm10physical
22922362
MED19_MOUSEMed19physical
22922362
AF10_MOUSEMllt10physical
22922362
MPP10_MOUSEMphosph10physical
22922362
MSH6_MOUSEMsh6physical
22922362
MSL1_MOUSEMsl1physical
22922362
MAP4_MOUSEMap4physical
22922362
MA7D1_MOUSEMap7d1physical
22922362
MYEF2_MOUSEMyef2physical
22922362
NACC1_MOUSENacc1physical
22922362
CNDG2_MOUSENcapg2physical
22922362
CNDH2_MOUSENcaph2physical
22922362
NDE1_MOUSENde1physical
22922362
NFAC2_MOUSENfatc2physical
22922362
NKRF_MOUSENkrfphysical
22922362
NOC4L_MOUSENoc4lphysical
22922362
NOL10_MOUSENol10physical
22922362
NOL12_MOUSENol12physical
22922362
NOP14_MOUSENop14physical
22922362
NOSIP_MOUSENosipphysical
22922362
NPM3_MOUSENpm3physical
22922362
NUDT5_MOUSENudt5physical
22922362
NU155_MOUSENup155physical
22922362
NU214_MOUSENup214physical
22922362
NUP88_MOUSENup88physical
22922362
NUSAP_MOUSENusap1physical
22922362
ORC1_MOUSEOrc1physical
22922362
ORC2_MOUSEOrc2physical
22922362
ORC3_MOUSEOrc3physical
22922362
PUR6_MOUSEPaicsphysical
22922362
GLD2_MOUSEPapd4physical
22922362
PARK7_MOUSEPark7physical
22922362
PDCD4_MOUSEPdcd4physical
22922362
PDC6I_MOUSEPdcd6ipphysical
22922362
PFKAL_MOUSEPfklphysical
22922362
PHC2_MOUSEPhc2physical
22922362
PLEC_MOUSEPlecphysical
22922362
PLK1_MOUSEPlk1physical
22922362
PLRG1_MOUSEPlrg1physical
22922362
DPOD1_MOUSEPold1physical
22922362
RPB1_MOUSEPolr2aphysical
22922362
PPIE_MOUSEPpiephysical
22922362
PPIG_MOUSEPpigphysical
22922362
PPIL2_MOUSEPpil2physical
22922362
2A5A_MOUSEPpp2r5aphysical
22922362
PRP4B_MOUSEPrpf4bphysical
22922362
PRP6_MOUSEPrpf6physical
22922362
PSME3_MOUSEPsme3physical
22922362
PWP2_MOUSEPwp2physical
22922362
QKI_MOUSEQkphysical
22922362
RAC2_MOUSERac2physical
22922362
RAD21_MOUSERad21physical
22922362
RAD51_MOUSERad51physical
22922362
RBP2_MOUSERanbp2physical
22922362
RAP1A_MOUSERap1aphysical
22922362
RBBP5_MOUSERbbp5physical
22922362
RBM19_MOUSERbm19physical
22922362
RBM28_MOUSERbm28physical
22922362
RBM34_MOUSERbm34physical
22922362
RBM5_MOUSERbm5physical
22922362
RBM8A_MOUSERbm8aphysical
22922362
RBMX2_MOUSERbmx2physical
22922362
RCOR1_MOUSERcor1physical
22922362
REXO4_MOUSERexo4physical
22922362
RIF1_MOUSERif1physical
22922362
RNPS1_MOUSERnps1physical
22922362
PTBP3_MOUSEPtbp3physical
22922362
RFA1_MOUSERpa1physical
22922362
AROS_MOUSERps19bp1physical
22922362
KS6A3_MOUSERps6ka3physical
22922362
RIR2_MOUSERrm2physical
22922362
RRP8_MOUSERrp8physical
22922362
U3IP2_MOUSERrp9physical
22922362
RSBN1_MOUSERsbn1physical
22922362
SAP18_MOUSESap18physical
22922362
SASH3_MOUSESash3physical
22922362
SEC13_MOUSESec13physical
22922362
SENP3_MOUSESenp3physical
22922362
SF3A3_MOUSESf3a3physical
22922362
SUGP1_MOUSESugp1physical
22922362
SI1L1_MOUSESipa1l1physical
22922362
SIR7_MOUSESirt7physical
22922362
SLTM_MOUSESltmphysical
22922362
SLU7_MOUSESlu7physical
22922362
SMCA4_MOUSESmarca4physical
22922362
SMCA5_MOUSESmarca5physical
22922362
SMRC1_MOUSESmarcc1physical
22922362
SMRC2_MOUSESmarcc2physical
22922362
SMCE1_MOUSESmarce1physical
22922362
SMHD1_MOUSESmchd1physical
22922362
RU17_MOUSESnrnp70physical
22922362
SNRPA_MOUSESnrpaphysical
22922362
SP110_MOUSESp110physical
22922362
SP2_MOUSESp2physical
22922362
SRRM1_MOUSESrrm1physical
22922362
SSBP3_MOUSESsbp3physical
22922362
STAT3_MOUSEStat3physical
22922362
STRAP_MOUSEStrapphysical
22922362
STRBP_MOUSEStrbpphysical
22922362
SUZ12_MOUSESuz12physical
22922362
TAF1_MOUSETaf1physical
22922362
TAF6L_MOUSETaf6lphysical
22922362
TBL1R_MOUSETbl1xr1physical
22922362
TBL3_MOUSETbl3physical
22922362
TDRD3_MOUSETdrd3physical
22922362
TFP11_MOUSETfip11physical
22922362
THOC3_MOUSEThoc3physical
22922362
THOC4_MOUSEAlyrefphysical
22922362
TIAR_MOUSETial1physical
22922362
TLN1_MOUSETln1physical
22922362
TNPO1_MOUSETnpo1physical
22922362
TOP1_MOUSETop1physical
22922362
TOPB1_MOUSETopbp1physical
22922362
T3JAM_MOUSETraf3ip3physical
22922362
TRI56_MOUSETrim56physical
22922362
P53_MOUSETrp53physical
22922362
TSR1_MOUSETsr1physical
22922362
TBA1C_MOUSETuba1cphysical
22922362
GCP2_MOUSETubgcp2physical
22922362
GCP3_MOUSETubgcp3physical
22922362
UBC12_MOUSEUbe2mphysical
22922362
UFD1_MOUSEUfd1lphysical
22922362
USO1_MOUSEUso1physical
22922362
UT14A_MOUSEUtp14aphysical
22922362
UTP15_MOUSEUtp15physical
22922362
SAS10_MOUSEUtp3physical
22922362
VAV_MOUSEVav1physical
22922362
TERA_MOUSEVcpphysical
22922362
WAC_MOUSEWacphysical
22922362
WDR3_MOUSEWdr3physical
22922362
WDR33_MOUSEWdr33physical
22922362
WDR76_MOUSEWdr76physical
22922362
NSD2_MOUSEWhsc1physical
22922362
NSD3_MOUSEWhsc1l1physical
22922362
WIZ_MOUSEWizphysical
22922362
SYF1_MOUSEXab2physical
22922362
YTHD2_MOUSEYthdf2physical
22922362
TYY1_MOUSEYy1physical
22922362
KAISO_MOUSEZbtb33physical
22922362
ZCHC8_MOUSEZcchc8physical
22922362
ZN638_MOUSEZfmlphysical
22922362
ZN148_MOUSEZfp148physical
22922362
ZN326_MOUSEZfp326physical
22922362
ZN346_MOUSEZfp346physical
22922362
ZN512_MOUSEZfp512physical
22922362
ZN771_MOUSEZfp771physical
22922362
CHIP_MOUSEStub1physical
23973223
HS71B_MOUSEHspa1bphysical
23973223

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FOXP3_MOUSE

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Related Literatures of Post-Translational Modification

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