MBNL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MBNL1_MOUSE
• UniProt AC: Q9JKP5
• Protein Name: Muscleblind-like protein 1
• Gene Name: Mbnl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 341
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasmic granule . Localized with DDX1, TIAL1 and YBX1 in stress granules upon stress. Localized in the cytoplasm of multinucleated myotubes.
• Protein Description: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs (By similarity)..
• Protein Sequence: MAVSVTPIRDTKWLTLEVCREFQRGTCSRPDTECKFAHPSKSCQVENGRVIACFDSLKGRCSRENCKYLHPPPHLKTQLEINGRNNLIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATSASAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKLMRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATAAAMGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPGSILCMTPATSVDTHNICRTSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAVSVTPIRDT ----CCCEECCCCCC	15.67	29514104
6	Phosphorylation	--MAVSVTPIRDTKW --CCCEECCCCCCCE	12.90	26643407
27	Glutathionylation	REFQRGTCSRPDTEC HHHHCCCCCCCCCCC	3.46	24333276
34	Glutathionylation	CSRPDTECKFAHPSK CCCCCCCCCCCCCCC	4.82	24333276
56	Phosphorylation	RVIACFDSLKGRCSR EEEEEECCCCCCCCC	16.24	29514104
58	Ubiquitination	IACFDSLKGRCSREN EEEECCCCCCCCCCC	48.54	-
245	Ubiquitination	PPAHLQAKIKAAQYQ CCHHHHHHHHHHHHH	31.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MBNL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MBNL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MBNL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MBNL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.