PLRG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLRG1_MOUSE
• UniProt AC: Q922V4
• Protein Name: Pleiotropic regulator 1
• Gene Name: Plrg1
• Organism: Mus musculus (Mouse).
• Sequence Length: 513
• Subcellular Localization: Nucleus . Nucleus speckle .
• Protein Description: Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing..
• Protein Sequence: MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPTSKENLKEKGPQNATDSYPHKQYPANQGQDVEYLVTGTHPYPAGPGVALTADTKIQRMPSESAAQSLAVALPSQTRVDANRTGPAGSEYRHPGASDRSQPTAMNSIMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTLDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPLLYTFASGSPDNIKQWKFPDGGFIQNLSGHNAIINTLAVNADGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDRSESRLLTAEADKTIKVYREDETATEETHPVSWKPEIIKRKRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVEEVQKH -------CCHHHHHH	8.48	-
39	Phosphorylation	PVPLDEESHKRKMAI CCCCCHHHHHHHHHH	32.06	-
82	Phosphorylation	DSYPHKQYPANQGQD CCCCCCCCCCCCCCC	14.76	25159016
119	Phosphorylation	TKIQRMPSESAAQSL CCCEECCCHHHHHHH	34.54	27600695
172	Ubiquitination	IMETGNTKNSALMAK HHHHCCCCCCHHHCC	53.56	22790023
183	Phosphorylation	LMAKKAPTMPKPQWH HHCCCCCCCCCCCCC	51.47	25159016
200	Phosphorylation	WKLYRVISGHLGWVR CHHHHHHCCCCCEEE	19.80	-
236	Ubiquitination	IWDLASGKLKLSLTG EEEECCCCEEEEEEC	39.70	22790023
388	Phosphorylation	PLLYTFASGSPDNIK HHHHHHCCCCCCCCC	35.30	26745281
390	Phosphorylation	LYTFASGSPDNIKQW HHHHCCCCCCCCCCC	26.95	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLRG1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLRG1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLRG1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLRG1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.