SNRPA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNRPA_MOUSE
• UniProt AC: Q62189
• Protein Name: U1 small nuclear ribonucleoprotein A
• Gene Name: Snrpa
• Organism: Mus musculus (Mouse).
• Sequence Length: 287
• Subcellular Localization: Nucleus.
• Protein Description: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity)..
• Protein Sequence: MATIATMPVPETRANHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRIMKMRGQAFVIFKEVTSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTYVERDRKREKRKPKSQETPAAKKAVQGGAAAPVVGAVQPVPGMPPMPQAPRIMHHMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATIATMPVP -----CCEEECCCCC	15.17	25777480
6	Phosphorylation	--MATIATMPVPETR --CCEEECCCCCCCC	20.39	25777480
19	Phosphorylation	TRANHTIYINNLNEK CCCCCEEEECCCCHH	9.96	29514104
26	Ubiquitination	YINNLNEKIKKDELK EECCCCHHHCHHHHH	59.77	22790023
41	Phosphorylation	KSLYAIFSQFGQILD HHHHHHHHHHHHHHH	20.63	28059163
56	Ubiquitination	ILVSRIMKMRGQAFV HHHHHHHHHCCCEEE	24.07	-
66	Acetylation	GQAFVIFKEVTSATN CCEEEEEEEHHHHHH	39.90	22826441
92	Phosphorylation	DKPMRIQYAKTDSDI CCCCEEEEEECCHHH	14.01	25293948
94	Ubiquitination	PMRIQYAKTDSDIIA CCEEEEEECCHHHHH	48.18	22790023
95	Phosphorylation	MRIQYAKTDSDIIAK CEEEEEECCHHHHHH	32.34	25293948
97	Phosphorylation	IQYAKTDSDIIAKMK EEEEECCHHHHHHHH	35.62	25293948
102	Ubiquitination	TDSDIIAKMKGTYVE CCHHHHHHHHCCCHH	30.64	22790023
104	Malonylation	SDIIAKMKGTYVERD HHHHHHHHCCCHHHH	47.60	30639696
104	Ubiquitination	SDIIAKMKGTYVERD HHHHHHHHCCCHHHH	47.60	27667366
121	Phosphorylation	REKRKPKSQETPAAK HHHCCCCCCCCHHHH	41.60	27841257
157	Methylation	PPMPQAPRIMHHMPG CCCCCCCCCHHCCCC	41.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNRPA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNRPA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNRPA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SNRPA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.