dbPTM

AATF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AATF_MOUSE
UniProt AC	Q9JKX4
Protein Name	Protein AATF
Gene Name	Aatf
Organism	Mus musculus (Mouse).
Sequence Length	526
Subcellular Localization	Nucleus, nucleolus .
Protein Description	May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity)..
Protein Sequence	MAAPQPLALQLEQLLNPRPREADPEADPEEATRARVIDRFDEGEEEKDDLAVSSIRKLAPVSLLDTDKRYSGKTTSRKAWKEDHWEQALPSSSDNEASDEGGSEDGDSEGLGLEEISEDVDEDLEDNKISDEGGSEDGDSEGLGLEEFSEDVEEDLEGEDEEDREEDRNSEDDGVVAAFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKDKGGPEFASALKNSHKALKALLRSLVDLQEELLFQYPDTRHIVNGAKPNTESEEISSEDDELVGEKKKQRKAPPKRKLEMEDYPSFMAKRFADFTIYRNHTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHIMMDKERLLRRTQTKRSAYRVLGKPEPVPEPVAETLPGEPETLPQGPANAHLRDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIRKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTAMSDDARTELFRSLFGQLNPPDADRGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAPQPLAL ------CCCCCCHHH	28.05	-
62	Phosphorylation	IRKLAPVSLLDTDKR HHHHCCEEHHCCCCC	23.35	-
75	Phosphorylation	KRYSGKTTSRKAWKE CCCCCCCCCCHHHHH	29.98	51457125
130	Phosphorylation	DLEDNKISDEGGSED HHHHCCCCCCCCCCC	31.08	25293948
135	Phosphorylation	KISDEGGSEDGDSEG CCCCCCCCCCCCCCC	43.29	25293948
140	Phosphorylation	GGSEDGDSEGLGLEE CCCCCCCCCCCCHHH	38.81	25293948
170	Phosphorylation	DREEDRNSEDDGVVA HHHHHCCCCCCCHHE	43.21	26239621
180	Phosphorylation	DGVVAAFSSVKVSEE CCHHEEEECEECCHH	29.51	18846507
181	Phosphorylation	GVVAAFSSVKVSEEV CHHEEEECEECCHHH	21.36	18846507
240	Phosphorylation	KGGPEFASALKNSHK CCCHHHHHHHHHHHH	39.18	-
281	Phosphorylation	VNGAKPNTESEEISS CCCCCCCCCCCCCCC	49.79	29138701
283	Phosphorylation	GAKPNTESEEISSED CCCCCCCCCCCCCCC	38.19	27087446
287	Phosphorylation	NTESEEISSEDDELV CCCCCCCCCCCHHHH	30.84	27087446
288	Phosphorylation	TESEEISSEDDELVG CCCCCCCCCCHHHHC	51.19	27087446
314	Phosphorylation	RKLEMEDYPSFMAKR CCCCHHCCHHHHHHH	6.35	22817900
316	Phosphorylation	LEMEDYPSFMAKRFA CCHHCCHHHHHHHHC	22.79	22817900
320	Acetylation	DYPSFMAKRFADFTI CCHHHHHHHHCCEEE	35.94	7622843
442	Phosphorylation	RELIERKTSSLDPND HHHHHHHCCCCCCCC	29.75	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AATF_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AATF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AATF_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MAGD1_MOUSE	Maged1	physical	17488777

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AATF_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287 AND SER-288, ANDMASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287 AND SER-288, ANDMASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287 AND SER-288, ANDMASS SPECTROMETRY.	17242355 [Abstract]