SF3A3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SF3A3_MOUSE
• UniProt AC: Q9D554
• Protein Name: Splicing factor 3A subunit 3
• Gene Name: Sf3a3
• Organism: Mus musculus (Mouse).
• Sequence Length: 501
• Subcellular Localization: Nucleus .
• Protein Description: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex (By similarity)..
• Protein Sequence: METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRYMEVSGNLRDLYDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPNEICVPMSVEFEELLKARENPSEEAQNLVEFTDEEGYGRYLDLHDCYLKYINLKASEKLDYITYLSIFDQLFDIPKERKNAEYKRYLEMLLEYLQDYTDRVKPLQDQNELFGKIQTDFEKKWDNGTFPGWPKETSSALTHAGAHLDLSAFSSWEELASLGLDRLKSALLALGLKCGGTLEERAQRLFSTKGKSLESLDTSLFAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEILGEQRQLTHENVQRKQARTGEEREEEEEEQISESESEDEENEIIYNPKNLPLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYRGPKAFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAVSLWAKLKLQKASERWQPDTEEEYEDSSGNVVNKKTYEDLKRQGLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------METILEQQ -------CHHHHHHH	10.40	-
54	Phosphorylation	QDRYMEVSGNLRDLY HHHHHHHCCCHHHHH	14.52	-
97	Acetylation	QIKEFHRKHPNEICV HHHHHHHHCCCCCEE	55.64	22826441
121	Phosphorylation	LKARENPSEEAQNLV HHHCCCCCHHHHHHH	60.70	25338131
131	Phosphorylation	AQNLVEFTDEEGYGR HHHHHHCCCCCCCCC	29.06	26525534
201	Ubiquitination	QDYTDRVKPLQDQNE HHHHHCCCCCCCHHH	40.69	-
212	Acetylation	DQNELFGKIQTDFEK CHHHHHHHHHCCHHH	25.06	22826441
220	Ubiquitination	IQTDFEKKWDNGTFP HHCCHHHHCCCCCCC	53.21	-
264	Acetylation	SLGLDRLKSALLALG HCCHHHHHHHHHHHC	34.28	22826441
277	Phosphorylation	LGLKCGGTLEERAQR HCCCCCCCHHHHHHH	19.11	25159016
291	Acetylation	RLFSTKGKSLESLDT HHHCCCCCCHHHHCH	54.12	22826441
292	Phosphorylation	LFSTKGKSLESLDTS HHCCCCCCHHHHCHH	46.14	20139300
295	Phosphorylation	TKGKSLESLDTSLFA CCCCCHHHHCHHHHC	36.52	20139300
298	Phosphorylation	KSLESLDTSLFAKNP CCHHHHCHHHHCCCC	32.40	22006019
299	Phosphorylation	SLESLDTSLFAKNPK CHHHHCHHHHCCCCC	22.58	29514104
303	Ubiquitination	LDTSLFAKNPKSKGT HCHHHHCCCCCCCCC	67.46	-
303	Acetylation	LDTSLFAKNPKSKGT HCHHHHCCCCCCCCC	67.46	23806337
352	Phosphorylation	VQRKQARTGEEREEE HHHHHHHCCCHHHHH	52.54	25619855
365	Phosphorylation	EEEEEQISESESEDE HHHHHHHCCCCCCHH	34.46	27087446
367	Phosphorylation	EEEQISESESEDEEN HHHHHCCCCCCHHCC	39.36	27087446
369	Phosphorylation	EQISESESEDEENEI HHHCCCCCCHHCCCC	60.68	27087446
378	Phosphorylation	DEENEIIYNPKNLPL HHCCCCCCCCCCCCC	30.95	25619855
414	Phosphorylation	NCEICGNYTYRGPKA CEEECCCEEECCCHH	7.16	-
420	Malonylation	NYTYRGPKAFQRHFA CEEECCCHHHHHHHH	65.73	26320211
475	Phosphorylation	SERWQPDTEEEYEDS HHHCCCCCHHHCCCC	52.56	25159016
479	Phosphorylation	QPDTEEEYEDSSGNV CCCCHHHCCCCCCCC	28.46	25159016
482	Phosphorylation	TEEEYEDSSGNVVNK CHHHCCCCCCCCCCH	28.36	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SF3A3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SF3A3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SF3A3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SF3A3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.