WDR76_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR76_MOUSE
• UniProt AC: A6PWY4
• Protein Name: WD repeat-containing protein 76
• Gene Name: Wdr76
• Organism: Mus musculus (Mouse).
• Sequence Length: 622
• Protein Description: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC..
• Protein Sequence: MSGSKAESEEKAGSKQCPLVQVNEYKENEHIAYTSLRPIQITTLRKTAKVYLYPFSLSNSKLGLLKLSKSPVVNNSSKSVVHKKKDRKKTRRKVLTSKMKALSSKADSLLLKSSVDAYTESTRLGPKRTSDSATLSVDAESSDEDSAPGLDDFSGLSPYERKRLRNIRENANFFASLQLAESAARLRGMIKKRESPESKRKRPKKKENEIGCRRSMRLLKVDPLGVSLPASPTQPTLVEEEENPLLPPGPLEMIPENQDDSSELLKASLKTWAEMSQTSNEKTKKGLSSIKSYKANLSGMVISEATVRKVTKGAISSVALHPSEVRTLVAAGAKSGQIGLWDLTQQSEDAMYVFYAHSRYVSCLSFSPTNPAHLLSLSYDGTLRCGDFSSAVFEEVYRNEGNSPSSFDFLNDSSSLLVGHWDGHLSLVDRRTPGTSYEKFFNSSLEKIRTVHVHPLSRQYFVTAGLRDVHVYDARFLKSRGSQPLISLTEHSKSIASAYFSPVTGNRVVTTCADCKLRVFDSSSISSQLPLLSTIRHNTVTGRWLTRFQAVWDPKQEDCFIVGSMDHPRRVEVFHESGKNVHSLWGECLVSVCSLSAVHPTRYILAGGNSSGKLHVFMHQET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	GLLKLSKSPVVNNSS CCEECCCCCCCCCCC	21.39	29895711
108	Phosphorylation	ALSSKADSLLLKSSV HHHCHHHHHHHHHHH	26.27	27600695
129	Phosphorylation	TRLGPKRTSDSATLS CCCCCCCCCCCCEEE	42.91	21149613
130	Phosphorylation	RLGPKRTSDSATLSV CCCCCCCCCCCEEEE	33.33	21149613
132	Phosphorylation	GPKRTSDSATLSVDA CCCCCCCCCEEEECC	23.95	26643407
134	Phosphorylation	KRTSDSATLSVDAES CCCCCCCEEEECCCC	24.42	26643407
136	Phosphorylation	TSDSATLSVDAESSD CCCCCEEEECCCCCC	17.37	26643407
141	Phosphorylation	TLSVDAESSDEDSAP EEEECCCCCCCCCCC	44.82	26239621
142	Phosphorylation	LSVDAESSDEDSAPG EEECCCCCCCCCCCC	36.20	26239621
146	Phosphorylation	AESSDEDSAPGLDDF CCCCCCCCCCCCCCC	34.02	26239621
154	Phosphorylation	APGLDDFSGLSPYER CCCCCCCCCCCHHHH	45.91	26643407
195	Phosphorylation	GMIKKRESPESKRKR HHHHHCCCHHHHCCC	37.69	-
215	Phosphorylation	NEIGCRRSMRLLKVD CHHCCHHHHEEEEEE	6.73	-
231	Phosphorylation	LGVSLPASPTQPTLV CCCCCCCCCCCCCCC	26.92	25338131
282	Methylation	MSQTSNEKTKKGLSS HHHCCCHHHHHHHHH	70.65	-
303	Phosphorylation	NLSGMVISEATVRKV CCCCCEECHHHHHHH	15.12	27357545
306	Phosphorylation	GMVISEATVRKVTKG CCEECHHHHHHHHCC	19.45	27357545
362	Phosphorylation	YAHSRYVSCLSFSPT EECCCEEEEEEECCC	10.62	24719451
365	Phosphorylation	SRYVSCLSFSPTNPA CCEEEEEEECCCCHH	28.18	24719451
460	Phosphorylation	VHPLSRQYFVTAGLR EEECCCCCEEEECCC	10.02	-
463	Phosphorylation	LSRQYFVTAGLRDVH CCCCCEEEECCCEEE	12.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR76_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR76_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR76_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of WDR76_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.