DSRAD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DSRAD_MOUSE
• UniProt AC: Q99MU3
• Protein Name: Double-stranded RNA-specific adenosine deaminase
• Gene Name: Adar
• Organism: Mus musculus (Mouse).
• Sequence Length: 1178
• Subcellular Localization: Isoform 1: Cytoplasm. Nucleus, nucleolus. Long forms starting at Met-1 are found predominantly in cytoplasm. Shuttles between the cytoplasm and nucleus.; Isoform 2: Cytoplasm. Nucleus, nucleolus. Long forms starting at Met-1 are found predominan
• Protein Description: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Does not affect polyomavirus replication but provides protection against virus-induced cytopathic effects. Essential for embryonic development and cell survival and plays a critical role in the maintenance of hematopoietic stem cells..
• Protein Sequence: MSQGFRGPTGVFPHQTQSYLDPSHEHSKWRYPQPQGPESYPRSFQLQQIEFLKGRLPEAPLIGIQTQSLPPFLPGHWPRFPGPPAQDRQLEIWEFPRSVTLRNQGFHIGPPLPPPHSRGTPWRGADGLCSHFRELSISQSPEQKVLNRLEELGEGKATTAHVLARELRIPKRDINRILYSLEKKGKLHRGRGKPPLWSLVPLSQAWTQPPGVVNPDSCIQEFPRGEPGLDSEDGDPASDLEGPSEPLDMAEIKEKICDYLFNVSNSSALNLAKNIGLTKARDVTSVLIDLERQGDVYRQGATPPIWYLTDKKRERLQMKRSTHSAPAPTPTAVPEATRSPSFPACHPPPAGASSSVAASKRVENGQEPAIKHESRHEARPGPMRLRPHAYHNGPSRAGYVASENGQWATDDIPDNLNSIHTAPGEFRAIMEMPSFYSPTLPRCSPYKKLTECQLKNPVSGLLEYAQFTSQTCDFNLIEQSGPSHEPRFKFQVVINGREFPPAEAGSKKVAKQDAAVKAMAILLREAKAKDSGQPEDLSHCPMEEDSEKPAEAQAPSSSATSLFSGKSPVTTLLECMHKLGNSCEFRLLSKEGPAHDPKFQYCVAVGAQTFPPVSAPSKKVAKQMAAEEAMKALQEEAASSADDQSGGANTDSLDESMAPNKIRRIGELVRYLNTNPVGGLLEYARSHGFAAEFKLIDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQDAADAALRVLIGESEKAEQLGFAEVTPVTGASLRRTMLLLSRSPDAHPKTLPLSGSTFHDQIAMLSHRCFNALTNSFQPSLLGRKILAAIIMKRDPEDMGVVVSLGTGNRCVKGDSLSLKGETVNDCHAEIISRRGFIRFLYSELMKYNHHTAKNSIFELARGGEKLQIKKTVSFHLYISTAPCGDGALFDKSCSDRAVESTESRHYPVFENPKQGKLRTKVENGEGTIPVESSDIVPTWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTHFLQPVYLKSVTLGYLFSQGHLTRAICCRVTRDGKAFEDGLRYPFIVNHPKVGRVSVYDSKRQSGKTKETSVNWCMADGYDLEILDGTRGTVDGPGKELSRVSKKNIFLQFKKLCSFRARRDLLQLSYGEAKKAARDYDLAKNYFKKSLRDMGYGNWISKPQEEKNFYLCPVPND

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Methylation	SHEHSKWRYPQPQGP CCCCCCCCCCCCCCC	36.67	24129315
30	Asymmetric dimethylarginine	SHEHSKWRYPQPQGP CCCCCCCCCCCCCCC	36.67	-
42	Asymmetric dimethylarginine	QGPESYPRSFQLQQI CCCCCCCCCEEHHHH	41.70	-
42	Methylation	QGPESYPRSFQLQQI CCCCCCCCCEEHHHH	41.70	24129315
53	Ubiquitination	LQQIEFLKGRLPEAP HHHHHHHCCCCCCCC	47.51	22790023
55	Dimethylation	QIEFLKGRLPEAPLI HHHHHCCCCCCCCEE	45.54	-
79	Dimethylation	FLPGHWPRFPGPPAQ CCCCCCCCCCCCCCC	45.24	-
100	Phosphorylation	WEFPRSVTLRNQGFH EECCCCEECCCCCCC	22.65	24719451
136	Phosphorylation	CSHFRELSISQSPEQ HHHHHHCCCCCCHHH	18.55	25521595
138	Phosphorylation	HFRELSISQSPEQKV HHHHCCCCCCHHHHH	22.64	25521595
140	Phosphorylation	RELSISQSPEQKVLN HHCCCCCCHHHHHHH	24.50	63809353
179	Phosphorylation	RDINRILYSLEKKGK HHHHHHHHHHHHCCC	14.61	21743459
180	Phosphorylation	DINRILYSLEKKGKL HHHHHHHHHHHCCCC	26.97	21743459
231	Phosphorylation	RGEPGLDSEDGDPAS CCCCCCCCCCCCCHH	42.50	25159016
238	Phosphorylation	SEDGDPASDLEGPSE CCCCCCHHHCCCCCC	48.38	25159016
244	Phosphorylation	ASDLEGPSEPLDMAE HHHCCCCCCCCCHHH	63.80	30635358
321	Phosphorylation	ERLQMKRSTHSAPAP HHHHHCCCCCCCCCC	25.59	25777480
322	Phosphorylation	RLQMKRSTHSAPAPT HHHHCCCCCCCCCCC	24.71	25777480
324	Phosphorylation	QMKRSTHSAPAPTPT HHCCCCCCCCCCCCC	35.72	25777480
329	Phosphorylation	THSAPAPTPTAVPEA CCCCCCCCCCCCCCC	35.06	25777480
331	Phosphorylation	SAPAPTPTAVPEATR CCCCCCCCCCCCCCC	42.64	25777480
337	Phosphorylation	PTAVPEATRSPSFPA CCCCCCCCCCCCCCC	29.98	25777480
339	Phosphorylation	AVPEATRSPSFPACH CCCCCCCCCCCCCCC	22.12	28066266
341	Phosphorylation	PEATRSPSFPACHPP CCCCCCCCCCCCCCC	45.14	28066266
353	Phosphorylation	HPPPAGASSSVAASK CCCCCCCCCCHHHHH	23.41	25777480
354	Phosphorylation	PPPAGASSSVAASKR CCCCCCCCCHHHHHC	28.44	25777480
355	Phosphorylation	PPAGASSSVAASKRV CCCCCCCCHHHHHCH	17.18	25777480
359	Phosphorylation	ASSSVAASKRVENGQ CCCCHHHHHCHHCCC	15.97	25777480
360	Acetylation	SSSVAASKRVENGQE CCCHHHHHCHHCCCC	56.59	30985433
434	Phosphorylation	RAIMEMPSFYSPTLP HHHHCCCCCCCCCCC	35.19	-
437	Phosphorylation	MEMPSFYSPTLPRCS HCCCCCCCCCCCCCC	14.92	29514104
444	Phosphorylation	SPTLPRCSPYKKLTE CCCCCCCCCCCCCCH	32.32	26745281
446	Phosphorylation	TLPRCSPYKKLTECQ CCCCCCCCCCCCHHH	12.40	26745281
511	Ubiquitination	AGSKKVAKQDAAVKA CCCHHHHHHHHHHHH	52.26	22790023
567	Phosphorylation	TSLFSGKSPVTTLLE HHHHCCCCHHHHHHH	28.29	28066266
570	Phosphorylation	FSGKSPVTTLLECMH HCCCCHHHHHHHHHH	18.34	28066266
571	Phosphorylation	SGKSPVTTLLECMHK CCCCHHHHHHHHHHH	29.58	28066266
582	Phosphorylation	CMHKLGNSCEFRLLS HHHHHCCCCEEEEEC	17.15	22324799
589	Phosphorylation	SCEFRLLSKEGPAHD CCEEEEECCCCCCCC	33.00	-
639	Phosphorylation	ALQEEAASSADDQSG HHHHHHHHCCCCCCC	32.86	30635358
640	Phosphorylation	LQEEAASSADDQSGG HHHHHHHCCCCCCCC	30.87	30635358
645	Phosphorylation	ASSADDQSGGANTDS HHCCCCCCCCCCCCC	46.30	30635358
650	Phosphorylation	DQSGGANTDSLDESM CCCCCCCCCCCCHHH	26.82	30635358
652	Phosphorylation	SGGANTDSLDESMAP CCCCCCCCCCHHHCC	35.36	30635358
656	Phosphorylation	NTDSLDESMAPNKIR CCCCCCHHHCCHHHH	21.66	30635358
757	Phosphorylation	QLGFAEVTPVTGASL HHCCCEEECCCCHHH	11.98	-
763	Phosphorylation	VTPVTGASLRRTMLL EECCCCHHHHHHHHH	24.61	-
772	Phosphorylation	RRTMLLLSRSPDAHP HHHHHHHHCCCCCCC	30.59	24719451
774	Phosphorylation	TMLLLSRSPDAHPKT HHHHHHCCCCCCCCC	24.61	25266776
847	Phosphorylation	NRCVKGDSLSLKGET CCCCCCCCCCCCCCC	28.64	23737553
849	Phosphorylation	CVKGDSLSLKGETVN CCCCCCCCCCCCCHH	31.80	23737553
1046	Phosphorylation	AFEDGLRYPFIVNHP CCCCCCCCCEEECCC	13.92	166897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DSRAD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DSRAD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DSRAD_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DSRAD_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.