| UniProt ID | FMNL1_MOUSE | |
|---|---|---|
| UniProt AC | Q9JL26 | |
| Protein Name | Formin-like protein 1 | |
| Gene Name | Fmnl1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1094 | |
| Subcellular Localization |
Cytoplasm. Cell membrane Lipid-anchor. Cytoplasmic vesicle, phagosome. Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1. |
|
| Protein Description | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. May play a role in the control of cell motility and survival of macrophages.. | |
| Protein Sequence | MGNAAGSAEQPAGPTASPPKQPAVPKQPMPAAGELEERFTRVLNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAYIQKLKSYLDTGGVSRKVASDWMSNLGFKRRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVAYDMESTDSVASGAEKSKPLDQSVEDLSKAPPSSVPKSRLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKSPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLMEYFRHEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNVFDVGTLLEETETKNAVLEHMEELQEQVATLTERLRDTENDSMAKIAELEKQLSQARKELETLRERFSESTPMGTSRRIPEPEKVPVPTVVRPSALELKVEELEEKGLIRILRGPGDVVSIEILPGAAATPSGDDAQAPRVSTDSPSTAESIPEAASPPPPPPPPPPPLPNLQSQQEAPPSAPPLAPPLPGCAEPPPAPPLPGDLPPPPPPPPLGTDGPVPPPPPPPPGGPPDILGGQGPDIGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMNDFEEHFKTKSQGPCLDISALKGKASQKAPTKTILIEANRAKNLAITLRKGNLGADRICQAIETYDLQTLSLDFLELLTRFLPTDYERSLIARFEKEQRPMEELSEEDRFMLRFSRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLGDVRSLQRGLELTQREFVRQDDCLVLKEFLRANSPTMDKLLADSKTAQEAYESVVEYFGENPKTTSPSMFFSLFSRFTKAYKKAEQEVEQWKKEAAADTSGREEPPTPKSPPKARRQQMDLISELKRKQQKEPLIYESDRDGAIEDIITDLRNQPYIRADTGRRSARRRPPGPPLPVTTDLAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Myristoylation | ------MGNAAGSAE ------CCCCCCCCC | - | ||
| 4 (in isoform 2) | Phosphorylation | - | 30635358 | ||
| 7 | Phosphorylation | -MGNAAGSAEQPAGP -CCCCCCCCCCCCCC | - | ||
| 126 | Phosphorylation | QVLRELETSLRTNHI HHHHHHHHHHHHCCH | 29176673 | ||
| 127 | Phosphorylation | VLRELETSLRTNHIG HHHHHHHHHHHCCHH | 29176673 | ||
| 178 | Phosphorylation | VASGAEKSKPLDQSV HHCCCCCCCCCCCCH | 28833060 | ||
| 184 | Phosphorylation | KSKPLDQSVEDLSKA CCCCCCCCHHHHHHC | 25521595 | ||
| 189 | Phosphorylation | DQSVEDLSKAPPSSV CCCHHHHHHCCCCCC | 28833060 | ||
| 194 | Phosphorylation | DLSKAPPSSVPKSRL HHHHCCCCCCCCCCE | 25367039 | ||
| 195 | Phosphorylation | LSKAPPSSVPKSRLT HHHCCCCCCCCCCEE | 25367039 | ||
| 202 | Phosphorylation | SVPKSRLTIKLTPAH CCCCCCEEEEECHHH | 22942356 | ||
| 206 | Phosphorylation | SRLTIKLTPAHSRKA CCEEEEECHHHHHHH | 25266776 | ||
| 210 | Phosphorylation | IKLTPAHSRKALRNS EEECHHHHHHHHHCC | 26824392 | ||
| 217 | Phosphorylation | SRKALRNSRIVSQKD HHHHHHCCCCCCCCC | 23737553 | ||
| 264 | Phosphorylation | ALSLNNKSPRTKALV HHHCCCCCHHHHHHH | 20139300 | ||
| 449 | Phosphorylation | LRERFSESTPMGTSR HHHHHHHCCCCCCCC | 29176673 | ||
| 450 | Phosphorylation | RERFSESTPMGTSRR HHHHHHCCCCCCCCC | 29176673 | ||
| 454 | Phosphorylation | SESTPMGTSRRIPEP HHCCCCCCCCCCCCC | 29176673 | ||
| 455 | Phosphorylation | ESTPMGTSRRIPEPE HCCCCCCCCCCCCCC | 29176673 | ||
| 499 | Phosphorylation | RGPGDVVSIEILPGA CCCCCEEEEEECCCC | 27566939 | ||
| 509 | Phosphorylation | ILPGAAATPSGDDAQ ECCCCCCCCCCCCCC | 25521595 | ||
| 511 | Phosphorylation | PGAAATPSGDDAQAP CCCCCCCCCCCCCCC | 22324799 | ||
| 678 | Phosphorylation | DFEEHFKTKSQGPCL HHHHHHCCCCCCCCC | 28833060 | ||
| 680 | Phosphorylation | EEHFKTKSQGPCLDI HHHHCCCCCCCCCCH | 28833060 | ||
| 688 | Phosphorylation | QGPCLDISALKGKAS CCCCCCHHHHCCCCC | - | ||
| 695 | Phosphorylation | SALKGKASQKAPTKT HHHCCCCCCCCCCCE | 24719451 | ||
| 904 | Phosphorylation | HFLDKAGSVSLDSVL CCHHCCCCCCHHHHH | 28833060 | ||
| 906 | Phosphorylation | LDKAGSVSLDSVLGD HHCCCCCCHHHHHHH | 28833060 | ||
| 909 | Phosphorylation | AGSVSLDSVLGDVRS CCCCCHHHHHHHHHH | 28833060 | ||
| 945 | Phosphorylation | KEFLRANSPTMDKLL HHHHHHCCCCHHHHH | 29176673 | ||
| 1010 | Phosphorylation | KKEAAADTSGREEPP HHHHHCCCCCCCCCC | 28833060 | ||
| 1011 | Phosphorylation | KEAAADTSGREEPPT HHHHCCCCCCCCCCC | 28833060 | ||
| 1018 | Phosphorylation | SGREEPPTPKSPPKA CCCCCCCCCCCCCHH | 23375375 | ||
| 1021 | Phosphorylation | EEPPTPKSPPKARRQ CCCCCCCCCCHHHHH | 25521595 | ||
| 1049 | Phosphorylation | KEPLIYESDRDGAIE CCCCEEECCCCCHHH | - | ||
| 1072 | Phosphorylation | QPYIRADTGRRSARR CCCEECCCCCCCCCC | 20531401 | ||
| 1076 | Phosphorylation | RADTGRRSARRRPPG ECCCCCCCCCCCCCC | 20531401 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FMNL1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FMNL1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FMNL1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of FMNL1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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