DHX30_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHX30_MOUSE
• UniProt AC: Q99PU8
• Protein Name: Putative ATP-dependent RNA helicase DHX30
• Gene Name: Dhx30
• Organism: Mus musculus (Mouse).
• Sequence Length: 1217
• Subcellular Localization: Isoform 3: Mitochondrion matrix, mitochondrion nucleoid.; Isoform 2: Cytoplasm.; Isoform 1: Cytoplasm.; Mitochondrion matrix, mitochondrion nucleoid . Cytoplasm . Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial n
• Protein Description: Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Associates with mitochondrial DNA. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1..
• Protein Sequence: MVTPVCNSSTWQPKDSSFLSWPEMFSLDSFRKDRTQHRQRQCKLPPPRLPPMCVNPAPGGTITRASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVTLHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGSPADSWWRPEPTMPPTSWRQLNPENIRPGGPAGLSRSLGREEEEDEEEELEEGTIDVTEFLSMTQQDSHNPLRDSRGGSFEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTKLATLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIEAFLSHYPVDSSWISPELRLQSDDILPLGKDSGPLSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLREFRRALGRMVERSLRSELAALPLSVQQEHGQLLALLAELLRGPCGSFDMRKTADD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 2)	Phosphorylation	-	4.26	29514104
10	Phosphorylation	TPVCNSSTWQPKDSS CCCCCCCCCCCCCCC	28.13	28576409
15 (in isoform 3)	Phosphorylation	-	57.08	28066266
29	Phosphorylation	PEMFSLDSFRKDRTQ HHHHCHHHHHHCHHH	32.04	-
66	Phosphorylation	GGTITRASRDLLKEF CCHHCHHHHHHHHHC	24.04	27149854
99	Phosphorylation	HAKDKLVYVHTNGPK CCCCCEEEEECCCCC	9.28	29514104
171	Phosphorylation	VLADRFGSPADSWWR HHHHHHCCCCHHCCC	17.76	25293948
249	Phosphorylation	LRDSRGGSFEMTDDD CCCCCCCCCEECCCH	22.36	25521595
253	Phosphorylation	RGGSFEMTDDDSAIR CCCCCEECCCHHHHH	29.13	28833060
297	Acetylation	QFHTVGTKTKLATLT CCCCCCCCCCCEEEE	37.42	7615727
299	Acetylation	HTVGTKTKLATLTLL CCCCCCCCCEEEEHH	37.37	7615739
403	Phosphorylation	SPELRLQSDDILPLG CHHHHCCCCCEECCC	41.67	28066266
468	Phosphorylation	PHRDTILSAIEQHPV CCHHHHHHHHHHCCE	24.29	17242355
488	Phosphorylation	DTGCGKTTRIPQLLL CCCCCCCCCHHHHHH	30.04	17242355
518	Phosphorylation	ITQPRRISAVSVAQR EECCCCCCEEHHHHH	22.32	-
652	Ubiquitination	YLEDILAKLGKHQYP HHHHHHHHHCCCCCC	55.09	22790023
652 (in isoform 3)	Ubiquitination	-	55.09	22790023
658 (in isoform 3)	Ubiquitination	-	10.75	-
991	Phosphorylation	YLEENLLYAPSLRFI HHHHHCCHHHHHHHH	21.45	18563927
1068	Phosphorylation	QGKFKPNSVTYRTKS CCCCCCCCEEEEECC	25.10	29176673
1070	Phosphorylation	KFKPNSVTYRTKSGN CCCCCCEEEEECCCC	13.70	29176673
1108	Phosphorylation	MAVKSNGSVFVRDSS EEEECCCCEEEECCC	19.34	24453211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHX30_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
15	S	Phosphorylation	[Isoform 3]: Phosphorylated on Ser-15.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHX30_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DHX30_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.