NUSAP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUSAP_MOUSE
• UniProt AC: Q9ERH4
• Protein Name: Nucleolar and spindle-associated protein 1
• Gene Name: Nusap1
• Organism: Mus musculus (Mouse).
• Sequence Length: 427
• Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Chromosome. Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase. Localizes to the mitotic spindle and to the chromosomes duri
• Protein Description: Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them..
• Protein Sequence: MTVPSAEELDSFKYSDLQNLAKRLGLRANMKADKLLKALKAHLNPETRKENKNQDENQFSTDETEIHVSSEEQAETESGGHVTKTRRRRRKKHKTIHGIPTSQTLLQDHLEMKGTDSSNFQNQENQENQDPRDTAEVPSLPEQRPEDGNAASSGEGEVNDIKDSKKPLEKRSLCTDEFSKLGNNKRTSATTPNFKKLHEARFKKMESIDEYIMRKKKHLKEHSSLNELKLDKKGIVTPVPPRGRLSVPCTPARQQCPQGHSATKMNVRFSAATKDNEHKCSLTKTPARKSPHVTAPGSASKGQAVFRTPKSKATERTSIAVITPFKLMTEATQTPSSSKKPVFDLKASLSRPLNYKPHKGKLKPWGQAKENNSLNERVSRVTFHRKTYKQPHLQTREERWKRQEQERKEKKEKLLEARRNLGVTKAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Methylation	LAKRLGLRANMKADK HHHHHCHHHHHCHHH	23.32	30988685
60	Phosphorylation	NQDENQFSTDETEIH CCCCCCCCCCCCEEE	25.78	26643407
61	Phosphorylation	QDENQFSTDETEIHV CCCCCCCCCCCEEEE	38.86	26643407
64	Phosphorylation	NQFSTDETEIHVSSE CCCCCCCCEEEECHH	42.95	26643407
69	Phosphorylation	DETEIHVSSEEQAET CCCEEEECHHHHCCC	20.19	26643407
70	Phosphorylation	ETEIHVSSEEQAETE CCEEEECHHHHCCCC	44.03	26643407
76	Phosphorylation	SSEEQAETESGGHVT CHHHHCCCCCCCCCC	38.17	26643407
78	Phosphorylation	EEQAETESGGHVTKT HHHCCCCCCCCCCHH	58.45	26643407
83	Phosphorylation	TESGGHVTKTRRRRR CCCCCCCCHHHHHHH	22.48	26643407
134	Phosphorylation	ENQDPRDTAEVPSLP CCCCCCCCCCCCCCC	26.46	25777480
139	Phosphorylation	RDTAEVPSLPEQRPE CCCCCCCCCCCCCCC	62.83	28066266
152	Phosphorylation	PEDGNAASSGEGEVN CCCCCCCCCCCCCCC	36.14	21149613
153	Phosphorylation	EDGNAASSGEGEVND CCCCCCCCCCCCCCC	35.82	21149613
164	Phosphorylation	EVNDIKDSKKPLEKR CCCCCCCCCCCHHHH	37.26	25777480
172	Phosphorylation	KKPLEKRSLCTDEFS CCCHHHHCCCHHHHH	38.57	28066266
175	Phosphorylation	LEKRSLCTDEFSKLG HHHHCCCHHHHHHHC	43.80	29550500
188	Phosphorylation	LGNNKRTSATTPNFK HCCCCCCCCCCCCHH	27.87	29514104
190	Phosphorylation	NNKRTSATTPNFKKL CCCCCCCCCCCHHHH	42.42	28066266
191	Phosphorylation	NKRTSATTPNFKKLH CCCCCCCCCCHHHHH	18.89	28066266
207	Phosphorylation	ARFKKMESIDEYIMR HHHHCCHHHHHHHHH	31.66	26239621
216	Sumoylation	DEYIMRKKKHLKEHS HHHHHHHHHHHHHCC	34.75	28289178
223	Phosphorylation	KKHLKEHSSLNELKL HHHHHHCCCCCCCCC	37.30	28066266
224	Phosphorylation	KHLKEHSSLNELKLD HHHHHCCCCCCCCCC	36.80	28066266
237	Phosphorylation	LDKKGIVTPVPPRGR CCCCCCEECCCCCCC	19.35	26643407
242	Methylation	IVTPVPPRGRLSVPC CEECCCCCCCEECCC	36.47	16289435
246	Phosphorylation	VPPRGRLSVPCTPAR CCCCCCEECCCCCHH	23.74	27149854
250	Phosphorylation	GRLSVPCTPARQQCP CCEECCCCCHHHHCC	17.57	26239621
261	Phosphorylation	QQCPQGHSATKMNVR HHCCCCCCCCEEEEE	44.45	-
285	Phosphorylation	HKCSLTKTPARKSPH CCCCCCCCCCCCCCC	19.56	29514104
290	Phosphorylation	TKTPARKSPHVTAPG CCCCCCCCCCCCCCC	18.06	22817900
294	Phosphorylation	ARKSPHVTAPGSASK CCCCCCCCCCCCCCC	24.89	23375375
298	Phosphorylation	PHVTAPGSASKGQAV CCCCCCCCCCCCCEE	28.45	25266776
300	Phosphorylation	VTAPGSASKGQAVFR CCCCCCCCCCCEEEE	38.73	19060867
308	Phosphorylation	KGQAVFRTPKSKATE CCCEEEECCCCCCCC	24.49	27600695
317	Phosphorylation	KSKATERTSIAVITP CCCCCCCCEEEEEEC	20.46	25619855
318	Phosphorylation	SKATERTSIAVITPF CCCCCCCEEEEEECC	18.12	25619855
323	Phosphorylation	RTSIAVITPFKLMTE CCEEEEEECCEEECC	18.97	22942356
329	Phosphorylation	ITPFKLMTEATQTPS EECCEEECCCCCCCC	32.67	29550500
332	Phosphorylation	FKLMTEATQTPSSSK CEEECCCCCCCCCCC	27.09	27600695
334	Phosphorylation	LMTEATQTPSSSKKP EECCCCCCCCCCCCC	22.30	25263469
336	Phosphorylation	TEATQTPSSSKKPVF CCCCCCCCCCCCCCE	51.10	26643407
337	Phosphorylation	EATQTPSSSKKPVFD CCCCCCCCCCCCCEE	47.59	25263469
338	Phosphorylation	ATQTPSSSKKPVFDL CCCCCCCCCCCCEEC	49.38	28066266
348	Phosphorylation	PVFDLKASLSRPLNY CCEECCHHHCCCCCC	25.87	-
356	Acetylation	LSRPLNYKPHKGKLK HCCCCCCCCCCCCCC	39.30	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUSAP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUSAP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUSAP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NUSAP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.