TAF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAF1_MOUSE
• UniProt AC: Q80UV9
• Protein Name: Transcription initiation factor TFIID subunit 1
• Gene Name: Taf1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1891
• Subcellular Localization: Nucleus .
• Protein Description: Largest component and core scaffold of the TFIID basal transcription factor complex. [PubMed: 10438527 Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4.]
• Protein Sequence: MGPGWAGLLQDKGGGSPSVVMSDTDSDEESAGGGPFSLTGFLFGNINGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELSGSDGALVNDEGWIRSREDAVDYSDINEVAEDESRRYQQTMGSLQPLCHTDYDEDDYDADCEDIDCKLMPPPPPPPGPLKKEKDQDDITGVSEDGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQDAAQSESKDGQLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEGQVQEEECSVELEVNQKSLWNYDYAPPPLPDQCLSDDEITMMAPVESKFSQSTGDTDKVMDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKMKKTEHESTIKCNIMKKLRKLEENSGVDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFTATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQNMPRILEPPVLTLDPNDENLILEIPDEKEEATSNSPSKENKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPESDFLIIRTRQGYFIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAAAGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKATVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVSPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCHQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDNNTSLSVSRDASVYQDESNLSVLDIPSATSEKQLTQEGGDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFFAIQLSESGSDSDVESGSLRPKQPRVLQENTRMGMENEESMMSYEGDGGDASRGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDTDLDSDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
204	Phosphorylation	ASEKVDFSSSSDSES CCCCCCCCCCCCCCC	25.50	25338131
205	Phosphorylation	SEKVDFSSSSDSESE CCCCCCCCCCCCCCC	33.58	25338131
206	Phosphorylation	EKVDFSSSSDSESEM CCCCCCCCCCCCCCC	36.65	25338131
207	Phosphorylation	KVDFSSSSDSESEMG CCCCCCCCCCCCCCC	47.29	25338131
211	Phosphorylation	SSSSDSESEMGPQDA CCCCCCCCCCCCCHH	36.51	25338131
302	Phosphorylation	QVQEEECSVELEVNQ CCCCEECEEEEEECC	23.16	30635358
328	Phosphorylation	PLPDQCLSDDEITMM CCCCCCCCCCEEEEE	51.12	25159016
333	Phosphorylation	CLSDDEITMMAPVES CCCCCEEEEEEECCH	9.99	22668510
542	Phosphorylation	PDEKEEATSNSPSKE CCHHHHHCCCCCCCC	31.55	26239621
543	Phosphorylation	DEKEEATSNSPSKEN CHHHHHCCCCCCCCC	42.21	26239621
545	Phosphorylation	KEEATSNSPSKENKK HHHHCCCCCCCCCCC	30.25	26239621
547	Phosphorylation	EATSNSPSKENKKES HHCCCCCCCCCCCHH	53.04	26643407
565	Acetylation	KSRILLGKTGVIKEE HHHHHHCCCCCCCCC	41.92	23806337
726	Acetylation	TKIKNYYKRKPGKDP HHHHHHHHCCCCCCC	43.52	1919687
788	Phosphorylation	SDFLIIRTRQGYFIR CCEEEEEECCCCHHH	19.55	-
792	Phosphorylation	IIRTRQGYFIRELVD EEEECCCCHHHHHHE	6.36	-
1159	Phosphorylation	RMLLAAGSAAAGNNH HHHHHHHHHHCCCCC	15.26	21183079
1171	Phosphorylation	NNHRDDDTASVTSLN CCCCCCCCCCCEECC	28.03	20415495
1173	Phosphorylation	HRDDDTASVTSLNSS CCCCCCCCCEECCCC	28.20	21082442
1175	Phosphorylation	DDDTASVTSLNSSAT CCCCCCCEECCCCHH	25.63	23429704
1176	Phosphorylation	DDTASVTSLNSSATG CCCCCCEECCCCHHC	24.33	27087446
1179	Phosphorylation	ASVTSLNSSATGRCL CCCEECCCCHHCCEE	27.00	21743459
1180	Phosphorylation	SVTSLNSSATGRCLK CCEECCCCHHCCEEE	28.86	28066266
1182	Phosphorylation	TSLNSSATGRCLKIY EECCCCHHCCEEEEE	27.40	28066266
1353	Phosphorylation	LGKQLIESADEVRRK ECHHHHHCHHHHHHH	33.74	25338131
1361	Phosphorylation	ADEVRRKSLVLKFPK HHHHHHHHHHHHCCH	23.15	27600695
1374	Acetylation	PKQQLPPKKKRRVGT CHHHCCCCCCCCCCC	69.82	30988441
1460	Phosphorylation	ENVRKRLYPSREEFR HHHHHHHCCCHHHHH	11.82	25367039
1462	Phosphorylation	VRKRLYPSREEFREH HHHHHCCCHHHHHHH	38.47	25367039
1477	Phosphorylation	LELIVKNSATYNGPK HHHHHHCCCCCCCCC	19.10	-
1654	Phosphorylation	LEEAELESLDPMTPG HHHHHHHCCCCCCCC	51.18	25338131
1659	Phosphorylation	LESLDPMTPGPYTPQ HHCCCCCCCCCCCCC	30.40	25338131
1684	Phosphorylation	LSVSRDASVYQDESN EEEECCCCEEECCCC	26.16	28066266
1686	Phosphorylation	VSRDASVYQDESNLS EECCCCEEECCCCCE	14.04	28066266
1690	Phosphorylation	ASVYQDESNLSVLDI CCEEECCCCCEEEEC	51.89	21183079
1693	Phosphorylation	YQDESNLSVLDIPSA EECCCCCEEEECCCC	25.53	21183079
1702	Phosphorylation	LDIPSATSEKQLTQE EECCCCCCCCHHHCC	42.38	25338131
1799	Phosphorylation	MGMENEESMMSYEGD CCCCCHHHHHCCCCC	17.38	28833060
1802	Phosphorylation	ENEESMMSYEGDGGD CCHHHHHCCCCCCCC	16.05	22322096
1803	Phosphorylation	NEESMMSYEGDGGDA CHHHHHCCCCCCCCC	13.16	28833060
1811	Phosphorylation	EGDGGDASRGLEDSN CCCCCCCCCCCCCCC	31.46	28833060
1817	Phosphorylation	ASRGLEDSNISYGSY CCCCCCCCCCCCCCC	27.04	25521595
1820	Phosphorylation	GLEDSNISYGSYEEP CCCCCCCCCCCCCCC	27.91	25521595
1821	Phosphorylation	LEDSNISYGSYEEPD CCCCCCCCCCCCCCC	13.29	25521595
1823	Phosphorylation	DSNISYGSYEEPDPK CCCCCCCCCCCCCCC	22.57	22942356
1824	Phosphorylation	SNISYGSYEEPDPKS CCCCCCCCCCCCCCC	21.68	22322096
1831	Phosphorylation	YEEPDPKSNTQDTSF CCCCCCCCCCCCCCC	50.96	27087446
1837	Phosphorylation	KSNTQDTSFSSIGGY CCCCCCCCCHHCCCE	31.27	30635358
1839	Phosphorylation	NTQDTSFSSIGGYEV CCCCCCCHHCCCEEC	22.32	30635358
1840	Phosphorylation	TQDTSFSSIGGYEVS CCCCCCHHCCCEECC	24.20	30635358
1844	Phosphorylation	SFSSIGGYEVSEEEE CCHHCCCEECCHHHH	14.14	30635358
1847	Phosphorylation	SIGGYEVSEEEEDEE HCCCEECCHHHHCHH	27.61	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAF1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAF1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TAF1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.