AF10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AF10_MOUSE
• UniProt AC: O54826
• Protein Name: Protein AF-10 {ECO:0000305}
• Gene Name: Mllt10 {ECO:0000312|MGI:MGI:1329038}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1068
• Subcellular Localization: Nucleus.
• Protein Description: Probably involved in transcriptional regulation. Binds to cruciform DNA (By similarity). In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (By similarity)..
• Protein Sequence: MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYEQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTAARFTNANFQEVSAHTSSGKDVSEARGSEGKGKKSSAHSSGQRGRKPGAGRNPGTAVSASSPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRSDSYTHTQQPSSTKDVHKGESGSQEAAVNSFSSLVGHPVTSTVISQPKSFDNSPGELGSSSLPTAGYKRAQTSGIEEEAVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAASSVTPAAATTQANTVSGSSLSQAPAHMYGSRLNQNPSMAVLIAQSESSQTDQDLGDNARSLGGRGSSPRGSLSPRSPVSNLQLRYDQPSNSSLETVPPVAASIEQLLERQWSEGQQFLLEQGTPGDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPAITTNPSPSHQMHTYTAQTAPPPDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQSSGVSGVQQVNGVTVGALASGMQTVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPAPLTHTSVPPNAAHPMPAAALTNSASGLGLLSDQQRQMFIQQQQFQQLLNSQQLTPEQHQAFLYQLMQQQHHPPELQQLQLPGPTQIPINNLLAGAQAPPLHTATTNPFLTIHGDSTSQKVTRLSDKTGPVAQEKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
217	Phosphorylation	RSYEQSLSDSSSHSQ CCHHHHHCCCCCCCC	40.47	26643407
219	Phosphorylation	YEQSLSDSSSHSQDK HHHHHCCCCCCCCHH	30.30	26643407
220	Phosphorylation	EQSLSDSSSHSQDKH HHHHCCCCCCCCHHH	36.74	26643407
221	Phosphorylation	QSLSDSSSHSQDKHH HHHCCCCCCCCHHHH	30.98	26643407
252	Phosphorylation	HKKQPEPSPALVPSL HCCCCCCCCCCCCCE	22.57	-
301	Phosphorylation	FQEVSAHTSSGKDVS HHHHHCCCCCCCCHH	25.06	-
302	Phosphorylation	QEVSAHTSSGKDVSE HHHHCCCCCCCCHHH	27.50	-
305	Acetylation	SAHTSSGKDVSEARG HCCCCCCCCHHHHCC	57.83	22826441
340	Phosphorylation	GAGRNPGTAVSASSP CCCCCCCCCCCCCCC	25.74	26643407
343	Phosphorylation	RNPGTAVSASSPFPQ CCCCCCCCCCCCCCC	21.70	26643407
345	Phosphorylation	PGTAVSASSPFPQGS CCCCCCCCCCCCCCC	30.91	26643407
346	Phosphorylation	GTAVSASSPFPQGSF CCCCCCCCCCCCCCC	30.21	26643407
352	Phosphorylation	SSPFPQGSFSGTPGS CCCCCCCCCCCCCCC	15.81	26643407
354	Phosphorylation	PFPQGSFSGTPGSVK CCCCCCCCCCCCCEE	43.38	26643407
356	Phosphorylation	PQGSFSGTPGSVKSS CCCCCCCCCCCEECC	24.23	26643407
359	Phosphorylation	SFSGTPGSVKSSSGS CCCCCCCCEECCCCC	27.81	26643407
362	Phosphorylation	GTPGSVKSSSGSSVQ CCCCCEECCCCCCCC	27.81	25293948
363	Phosphorylation	TPGSVKSSSGSSVQS CCCCEECCCCCCCCC	32.76	26745281
364	Phosphorylation	PGSVKSSSGSSVQSP CCCEECCCCCCCCCH	50.19	26745281
366	Phosphorylation	SVKSSSGSSVQSPQD CEECCCCCCCCCHHH	29.32	25293948
367	Phosphorylation	VKSSSGSSVQSPQDF EECCCCCCCCCHHHH	27.92	26745281
370	Phosphorylation	SSGSSVQSPQDFLSF CCCCCCCCHHHHHHC	23.52	26745281
376	Phosphorylation	QSPQDFLSFTDSDLR CCHHHHHHCCCHHHC	26.54	25293948
378	Phosphorylation	PQDFLSFTDSDLRSD HHHHHHCCCHHHCCC	31.08	25293948
380	Phosphorylation	DFLSFTDSDLRSDSY HHHHCCCHHHCCCCC	35.17	25293948
384	Phosphorylation	FTDSDLRSDSYTHTQ CCCHHHCCCCCCCCC	37.90	26745281
404	Phosphorylation	KDVHKGESGSQEAAV CCCCCCCCCCHHHHH	53.03	25293948
406	Phosphorylation	VHKGESGSQEAAVNS CCCCCCCCHHHHHHH	33.84	25293948
432	Phosphorylation	TVISQPKSFDNSPGE HEECCCCCCCCCCCC	44.51	25521595
436	Phosphorylation	QPKSFDNSPGELGSS CCCCCCCCCCCCCCC	35.81	21082442
442	Phosphorylation	NSPGELGSSSLPTAG CCCCCCCCCCCCCCC	29.40	28833060
443	Phosphorylation	SPGELGSSSLPTAGY CCCCCCCCCCCCCCH	33.81	28833060
444	Phosphorylation	PGELGSSSLPTAGYK CCCCCCCCCCCCCHH	39.81	28833060
451	Acetylation	SLPTAGYKRAQTSGI CCCCCCHHHHHCCCC	40.10	129109
491	Phosphorylation	NKNQENVSHLSVSSA CCCCCCCCEEEECCC	30.23	25293948
494	Phosphorylation	QENVSHLSVSSASPT CCCCCEEEECCCCCC	17.96	25293948
496	Phosphorylation	NVSHLSVSSASPTSS CCCEEEECCCCCCCH	19.46	26745281
497	Phosphorylation	VSHLSVSSASPTSSV CCEEEECCCCCCCHH	30.52	26745281
499	Phosphorylation	HLSVSSASPTSSVAS EEEECCCCCCCHHHH	30.56	26745281
501	Phosphorylation	SVSSASPTSSVASAA EECCCCCCCHHHHHH	31.01	25293948
502	Phosphorylation	VSSASPTSSVASAAG ECCCCCCCHHHHHHC	26.63	25293948
503	Phosphorylation	SSASPTSSVASAAGS CCCCCCCHHHHHHCC	24.95	25293948
506	Phosphorylation	SPTSSVASAAGSVTS CCCCHHHHHHCCCCC	19.25	25293948
510	Phosphorylation	SVASAAGSVTSSSLQ HHHHHHCCCCCHHHC	19.93	25293948
512	Phosphorylation	ASAAGSVTSSSLQKS HHHHCCCCCHHHCCC	25.29	26643407
513	Phosphorylation	SAAGSVTSSSLQKSP HHHCCCCCHHHCCCC	18.77	25293948
514	Phosphorylation	AAGSVTSSSLQKSPT HHCCCCCHHHCCCCC	26.21	25293948
515	Phosphorylation	AGSVTSSSLQKSPTL HCCCCCHHHCCCCCE	34.29	25293948
519	Phosphorylation	TSSSLQKSPTLLRNG CCHHHCCCCCEECCC	15.34	26643407
521	Phosphorylation	SSLQKSPTLLRNGSL HHHCCCCCEECCCCC	45.58	26643407
527	Phosphorylation	PTLLRNGSLQSLSVG CCEECCCCCCEEEEC	27.13	25293948
530	Phosphorylation	LRNGSLQSLSVGSSP ECCCCCCEEEECCCC	28.09	25293948
532	Phosphorylation	NGSLQSLSVGSSPVG CCCCCEEEECCCCCC	29.67	22817900
535	Phosphorylation	LQSLSVGSSPVGSEI CCEEEECCCCCCCEE	29.34	19060867
536	Phosphorylation	QSLSVGSSPVGSEIS CEEEECCCCCCCEEE	20.06	22817900
540	Phosphorylation	VGSSPVGSEISMQYR ECCCCCCCEEEECCC	31.80	25293948
543	Phosphorylation	SPVGSEISMQYRHDG CCCCCEEEECCCCCC	8.86	25293948
546	Phosphorylation	GSEISMQYRHDGACP CCEEEECCCCCCCCC	10.98	25293948
681	Phosphorylation	RSLGGRGSSPRGSLS HHCCCCCCCCCCCCC	35.49	26643407
682	Phosphorylation	SLGGRGSSPRGSLSP HCCCCCCCCCCCCCC	22.80	26643407
686	Phosphorylation	RGSSPRGSLSPRSPV CCCCCCCCCCCCCCC	27.27	21082442
688	Phosphorylation	SSPRGSLSPRSPVSN CCCCCCCCCCCCCCC	21.69	21082442
691	Phosphorylation	RGSLSPRSPVSNLQL CCCCCCCCCCCCEEE	32.79	21082442
694	Phosphorylation	LSPRSPVSNLQLRYD CCCCCCCCCEEEEEC	34.90	26643407
700	Phosphorylation	VSNLQLRYDQPSNSS CCCEEEEECCCCCCC	27.76	25293948
704	Phosphorylation	QLRYDQPSNSSLETV EEEECCCCCCCCCCC	43.65	25293948
706	Phosphorylation	RYDQPSNSSLETVPP EECCCCCCCCCCCCC	40.41	25293948
707	Phosphorylation	YDQPSNSSLETVPPV ECCCCCCCCCCCCCH	34.18	25293948
710	Phosphorylation	PSNSSLETVPPVAAS CCCCCCCCCCCHHHH	43.54	25293948
717	Phosphorylation	TVPPVAASIEQLLER CCCCHHHHHHHHHHH	19.54	25293948
781	Phosphorylation	QLLNAQLSVPFPAIT HHHHCCCCCCCCCCC	18.70	25293948
788	Phosphorylation	SVPFPAITTNPSPSH CCCCCCCCCCCCCCC	23.72	25293948
789	Phosphorylation	VPFPAITTNPSPSHQ CCCCCCCCCCCCCCC	38.73	25293948
792	Phosphorylation	PAITTNPSPSHQMHT CCCCCCCCCCCCCEE	40.90	25293948
794	Phosphorylation	ITTNPSPSHQMHTYT CCCCCCCCCCCEEEE	30.59	25293948
799	Phosphorylation	SPSHQMHTYTAQTAP CCCCCCEEEECCCCC	19.75	25293948
800	Phosphorylation	PSHQMHTYTAQTAPP CCCCCEEEECCCCCC	5.84	25293948
801	Phosphorylation	SHQMHTYTAQTAPPP CCCCEEEECCCCCCC	17.28	25293948
804	Phosphorylation	MHTYTAQTAPPPDSL CEEEECCCCCCCCCC	38.37	25293948
810	Phosphorylation	QTAPPPDSLNSSKSP CCCCCCCCCCCCCCC	34.91	25293948
813	Phosphorylation	PPPDSLNSSKSPHIG CCCCCCCCCCCCCCC	44.42	25293948
814	Phosphorylation	PPDSLNSSKSPHIGN CCCCCCCCCCCCCCC	35.76	25293948
1057	Phosphorylation	SQKVTRLSDKTGPVA CCEEEECCCCCCCCC	33.50	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AF10_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AF10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AF10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGPD5_HUMAN	RGPD5	physical	11774384
ZBTB3_MOUSE	Zbtb3	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.