H10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H10_MOUSE
• UniProt AC: P10922
• Protein Name: Histone H1.0
• Gene Name: H1f0
• Organism: Mus musculus (Mouse).
• Sequence Length: 194
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division..
• Protein Sequence: MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKGDEPKRSVAFKKTKKEVKKVATPKKAAKPKKAASKAPSKKPKATPVKKAKKKPAATPKKAKKPKVVKVKPVKASKPKKAKTVKPKAKSSAKRASKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTENSTSA -------CCCCCCCC	10.80	-
2	Acetylation	------MTENSTSAP ------CCCCCCCCC	43.82	-
2	Phosphorylation	------MTENSTSAP ------CCCCCCCCC	43.82	24068923
5	Phosphorylation	---MTENSTSAPAAK ---CCCCCCCCCCCC	19.94	26824392
6	Phosphorylation	--MTENSTSAPAAKP --CCCCCCCCCCCCC	40.25	21743459
7	Phosphorylation	-MTENSTSAPAAKPK -CCCCCCCCCCCCCC	31.88	21743459
12	Malonylation	STSAPAAKPKRAKAS CCCCCCCCCCHHCCC	53.85	26320211
12	Acetylation	STSAPAAKPKRAKAS CCCCCCCCCCHHCCC	53.85	23806337
27	Ubiquitination	KKSTDHPKYSDMIVA CCCCCCCCHHHHHHH	54.70	22790023
27	Acetylation	KKSTDHPKYSDMIVA CCCCCCCCHHHHHHH	54.70	22826441
40	Ubiquitination	VAAIQAEKNRAGSSR HHHHHHHHHCCCCCH	55.54	22790023
42	Citrullination	AIQAEKNRAGSSRQS HHHHHHHCCCCCHHH	51.93	-
42	Citrullination	AIQAEKNRAGSSRQS HHHHHHHCCCCCHHH	51.93	-
45	Phosphorylation	AEKNRAGSSRQSIQK HHHHCCCCCHHHHHH	22.74	23684622
46	Phosphorylation	EKNRAGSSRQSIQKY HHHCCCCCHHHHHHH	33.16	23684622
49	Phosphorylation	RAGSSRQSIQKYIKS CCCCCHHHHHHHHHH	26.35	23684622
52	Ubiquitination	SSRQSIQKYIKSHYK CCHHHHHHHHHHHHC	47.47	27667366
55	Ubiquitination	QSIQKYIKSHYKVGE HHHHHHHHHHHCCCC	28.26	27667366
59	Acetylation	KYIKSHYKVGENADS HHHHHHHCCCCCCCH	38.04	23954790
59	Ubiquitination	KYIKSHYKVGENADS HHHHHHHCCCCCCCH	38.04	27667366
59	Malonylation	KYIKSHYKVGENADS HHHHHHHCCCCCCCH	38.04	26320211
66	Phosphorylation	KVGENADSQIKLSIK CCCCCCCHHHHHHHH	31.25	29472430
69	Ubiquitination	ENADSQIKLSIKRLV CCCCHHHHHHHHHHH	28.66	27667366
82	Acetylation	LVTTGVLKQTKGVGA HHHHCCCCCCCCCCC	54.22	22826441
82	Malonylation	LVTTGVLKQTKGVGA HHHHCCCCCCCCCCC	54.22	26320211
82	Ubiquitination	LVTTGVLKQTKGVGA HHHHCCCCCCCCCCC	54.22	27667366
85	Ubiquitination	TGVLKQTKGVGASGS HCCCCCCCCCCCCCC	49.45	22790023
90	Phosphorylation	QTKGVGASGSFRLAK CCCCCCCCCCEEECC	29.10	29472430
92	Phosphorylation	KGVGASGSFRLAKGD CCCCCCCCEEECCCC	12.51	26824392
97	Ubiquitination	SGSFRLAKGDEPKRS CCCEEECCCCCCCCC	72.05	27667366
104	Phosphorylation	KGDEPKRSVAFKKTK CCCCCCCCCCCCCCH	24.75	29176673
104	ADP-ribosylation	KGDEPKRSVAFKKTK CCCCCCCCCCCCCCH	24.75	-
108	Ubiquitination	PKRSVAFKKTKKEVK CCCCCCCCCCHHHHH	50.20	27667366
141	Phosphorylation	PSKKPKATPVKKAKK CCCCCCCCCCHHHCC	34.44	27149854
149	Ubiquitination	PVKKAKKKPAATPKK CCHHHCCCCCCCCCC	38.90	-
153	Phosphorylation	AKKKPAATPKKAKKP HCCCCCCCCCCCCCC	37.43	27149854
155	Ubiquitination	KKPAATPKKAKKPKV CCCCCCCCCCCCCCE	62.09	-
164	Malonylation	AKKPKVVKVKPVKAS CCCCCEEEEEECCCC	47.75	26320211
171	Phosphorylation	KVKPVKASKPKKAKT EEEECCCCCCCCCCC	43.72	27149854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H10_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H10_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of H10_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.