PTBP3_MOUSE - dbPTM
PTBP3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTBP3_MOUSE
UniProt AC Q8BHD7
Protein Name Polypyrimidine tract-binding protein 3
Gene Name Ptbp3
Organism Mus musculus (Mouse).
Sequence Length 523
Subcellular Localization
Protein Description RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes Fas exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U) (By similarity)..
Protein Sequence MNSSTSAGVYANGNDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNLSLPGATANEGTLLPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIMSSPYAGAAGFAPAIAFPQAAGLSVPAVPGALGPLTLTSSAVSGRMAIPGASGMPGNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationSSTSAGVYANGNDNK
CCCCCCCCCCCCCCC		8.0725162660
27PhosphorylationKGDRPPCSPSRVLHL
CCCCCCCCHHHEEEE		31.5127087446
29PhosphorylationDRPPCSPSRVLHLRK
CCCCCCHHHEEEEEE		20.8027742792
36UbiquitinationSRVLHLRKIPCDVTE
HHEEEEEECCCCCCH		58.31-
55PhosphorylationSLGLPFGKVTNLLML
HCCCCCCCCHHHHHH		46.3924719451
63UbiquitinationVTNLLMLKGKSQAFL
CHHHHHHCCCCHHHH		50.78-
98PhosphorylationHLRSQPVYIQYSNHR
HHHCCCEEEEECCCC		6.7622817900
102PhosphorylationQPVYIQYSNHRELKT
CCEEEEECCCCCCCC		15.13-
108UbiquitinationYSNHRELKTDNLPNQ
ECCCCCCCCCCCCHH		49.43-
109PhosphorylationSNHRELKTDNLPNQA
CCCCCCCCCCCCHHH		42.62-
130PhosphorylationQAVSAVQSGNLSLPG
HHHHHHHHCCCCCCC		24.0526060331
134PhosphorylationAVQSGNLSLPGATAN
HHHHCCCCCCCCCCC		36.2030352176
181UbiquitinationSKFGTVLKIITFTKN
HHHCCEEEEEEECCC		27.94-
187UbiquitinationLKIITFTKNNQFQAL
EEEEEECCCCHHHHH		50.11-
228UbiquitinationTLRIDFSKLTSLNVK
EEEECHHHCCCCEEE		56.64-
235AcetylationKLTSLNVKYNNDKSR
HCCCCEEEECCCCCC		40.98130177
235UbiquitinationKLTSLNVKYNNDKSR
HCCCCEEEECCCCCC		40.98-
394UbiquitinationSGQRLYGKVLRATLS
CHHHHHHHHHHHHHC		25.25-
394AcetylationSGQRLYGKVLRATLS
CHHHHHHHHHHHHHC		25.2522826441
399PhosphorylationYGKVLRATLSKHQAV
HHHHHHHHHCHHCCE		25.7329176673
401PhosphorylationKVLRATLSKHQAVQL
HHHHHHHCHHCCEEC		24.6029176673
402UbiquitinationVLRATLSKHQAVQLP
HHHHHHCHHCCEECC		42.73-
420UbiquitinationQEDQGLTKDFSNSPL
CCCCCCCCCCCCCCC		62.92-
423PhosphorylationQGLTKDFSNSPLHRF
CCCCCCCCCCCCCCC		46.6722817900
425PhosphorylationLTKDFSNSPLHRFKK
CCCCCCCCCCCCCCC		27.8622817900
435PhosphorylationHRFKKPGSKNFQNIF
CCCCCCCCCCCCCCC		32.7127681418
472PhosphorylationLFTEAGCSVKAFKFF
HHHHCCCCEEHHHHH		26.2429176673
474UbiquitinationTEAGCSVKAFKFFQK
HHCCCCEEHHHHHHH		31.63-
477UbiquitinationGCSVKAFKFFQKDRK
CCCEEHHHHHHHCCC		50.56-
481AcetylationKAFKFFQKDRKMALI
EHHHHHHHCCCEEEH		55.1122826441
483MethylationFKFFQKDRKMALIQL
HHHHHHCCCEEEHHH		37.3718963517
483DimethylationFKFFQKDRKMALIQL
HHHHHHCCCEEEHHH		37.37-
519PhosphorylationHHLRVSFSKSTI---
CEEEEEEECCCC---		20.4229176673
521PhosphorylationLRVSFSKSTI-----
EEEEEECCCC-----		30.0923684622
522PhosphorylationRVSFSKSTI------
EEEEECCCC------		34.1523684622
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTBP3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTBP3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTBP3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PTBP3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTBP3_MOUSE

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Related Literatures of Post-Translational Modification

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