AP3S1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP3S1_MOUSE
• UniProt AC: Q9DCR2
• Protein Name: AP-3 complex subunit sigma-1
• Gene Name: Ap3s1
• Organism: Mus musculus (Mouse).
• Sequence Length: 193
• Subcellular Localization: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex..
• Protein Description: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals..
• Protein Sequence: MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Ubiquitination	HGKPRLSKFYQPYSE CCCCCHHHCCCCCCH	53.32	-
132	Phosphorylation	MGGMVLETNMNEIVT HCCEEEECCHHHHHH	35.29	-
139	Phosphorylation	TNMNEIVTQIDAQNK CCHHHHHHHHHHHHH	26.01	-
150	Phosphorylation	AQNKLEKSEAGLAGA HHHHHHHCHHHHCCC	24.25	22817900
163	Phosphorylation	GAPARAVSAVKNMNL CCCHHHHHHHHCCCC	26.76	22817900
166	Ubiquitination	ARAVSAVKNMNLPEI HHHHHHHHCCCCCCC	50.63	-
183	Phosphorylation	NINIGDISIKVPNLP CCEECCCEEECCCCC	22.54	23984901
185	Ubiquitination	NIGDISIKVPNLPSF EECCCEEECCCCCCC	44.86	-
191	Phosphorylation	IKVPNLPSFK----- EECCCCCCCC-----	49.16	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP3S1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP3S1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP3S1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AP3S1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.