EXOS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXOS1_MOUSE
• UniProt AC: Q9DAA6
• Protein Name: Exosome complex component CSL4
• Gene Name: Exosc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 195
• Subcellular Localization: Nucleus, nucleolus. Nucleus. Cytoplasm.
• Protein Description: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8 (By similarity)..
• Protein Sequence: MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKTSENGAVPVVSVMRETESQLLPDVGAVVTCKVSSINSRFAKVHILYVGSTPLKNAFRGTIRKEDIRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGVQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	LCNLEEGSPGSGTYT EECCCCCCCCCCCEE	29.39	26643407
24	Phosphorylation	LEEGSPGSGTYTRHG CCCCCCCCCCEECCC	31.20	28066266
26	Phosphorylation	EGSPGSGTYTRHGYI CCCCCCCCEECCCEE	24.34	28066266
28	Phosphorylation	SPGSGTYTRHGYIFS CCCCCCEECCCEEEH	18.94	28066266
32	Phosphorylation	GTYTRHGYIFSSLAG CCEECCCEEEHHHCC	7.83	29514104
119	Phosphorylation	EKDKVEIYKSFRPGD CHHCEEHHHHCCCCC	6.25	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXOS1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXOS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXOS1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXOS9_HUMAN	EXOSC9	physical	26496610
EXOSX_HUMAN	EXOSC10	physical	26496610
DGKD_HUMAN	DGKD	physical	26496610
MPH6_HUMAN	MPHOSPH6	physical	26496610
C1D_HUMAN	C1D	physical	26496610
HBS1L_HUMAN	HBS1L	physical	26496610
EXOS8_HUMAN	EXOSC8	physical	26496610
EXOS7_HUMAN	EXOSC7	physical	26496610
EXOS2_HUMAN	EXOSC2	physical	26496610
EXOS3_HUMAN	EXOSC3	physical	26496610
EXOS4_HUMAN	EXOSC4	physical	26496610
EXOS5_HUMAN	EXOSC5	physical	26496610
DYHC2_HUMAN	DYNC2H1	physical	26496610
DI3L1_HUMAN	DIS3L	physical	26496610
EXOS6_HUMAN	EXOSC6	physical	26496610
ZC3H1_HUMAN	ZFC3H1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.