DGKD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DGKD_HUMAN
• UniProt AC: Q16760
• Protein Name: Diacylglycerol kinase delta
• Gene Name: DGKD
• Organism: Homo sapiens (Human).
• Sequence Length: 1214
• Subcellular Localization: Isoform 2: Cytoplasm .; Isoform 1: Membrane ; Peripheral membrane protein .
• Protein Description: May function as signaling molecule.; Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis..
• Protein Sequence: MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRILCGIKELSRSAPAVEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 2)	Phosphorylation	-	33.61	-
44	Phosphorylation	QKLIRKVSTSGQIRQ HHHHHHHCCCCCCCC	21.64	23401153
45	Phosphorylation	KLIRKVSTSGQIRQK HHHHHHCCCCCCCCE	39.60	30266825
46	Phosphorylation	LIRKVSTSGQIRQKT HHHHHCCCCCCCCEE	22.61	30266825
62	Ubiquitination	IKEGMLTKQNNSFQR HHHCCCCCCCCCCHH	47.25	-
66	Phosphorylation	MLTKQNNSFQRSKRR CCCCCCCCCHHHHHH	30.24	22817900
70	Phosphorylation	QNNSFQRSKRRYFKL CCCCCHHHHHHHHHH	21.52	22817900
83	Phosphorylation	KLRGRTLYYAKTAKS HHCCCEEEEEECCCE	10.77	25954137
84	Phosphorylation	LRGRTLYYAKTAKSI HCCCEEEEEECCCEE	12.53	25954137
87	Phosphorylation	RTLYYAKTAKSIIFD CEEEEEECCCEEEEE	31.01	25954137
89	Ubiquitination	LYYAKTAKSIIFDEV EEEEECCCEEEEEEC	47.63	-
99	Phosphorylation	IFDEVDLTDASVAES EEEECCCCCCHHHHH	25.67	25954137
102	Phosphorylation	EVDLTDASVAESSTK ECCCCCCHHHHHCCC	25.35	25954137
123	Ubiquitination	TVITPCRKLILCADN EEEECCCEEEEECCC	46.74	-
132	Ubiquitination	ILCADNRKEMEDWIA EEECCCHHHHHHHHH	68.61	-
254	Ubiquitination	AKCTVCDKTCGSVLR CEEEECCCCCCCEEH	40.36	-
276	Phosphorylation	WCKAMVHTSCKESLL HHHHHHCCCHHHHHH	25.14	28387310
281	Phosphorylation	VHTSCKESLLTKCPL HCCCHHHHHHHCCCC	17.74	24719451
285	Ubiquitination	CKESLLTKCPLGLCK HHHHHHHCCCCCCEE	33.55	-
303	Phosphorylation	IPPTALNSIDSDGFW CCCCCCCCCCCCCCC	28.73	28348404
306	Phosphorylation	TALNSIDSDGFWKAS CCCCCCCCCCCCCCC	37.65	28348404
337	Ubiquitination	SGDNQGVKFLRRFKQ CCCCHHHHHHHHHHH	45.57	-
337	Acetylation	SGDNQGVKFLRRFKQ CCCCHHHHHHHHHHH	45.57	25953088
434	Ubiquitination	QLPQILEKLERASTK CHHHHHHHHHHHCHH	52.80	-
439	Phosphorylation	LEKLERASTKMLDRW HHHHHHHCHHHHHHH	34.48	23403867
440	Phosphorylation	EKLERASTKMLDRWS HHHHHHCHHHHHHHH	21.35	-
454	Ubiquitination	SVMAYEAKLPRQASS HHHHHEECCCCCCCC	47.27	-
460	Phosphorylation	AKLPRQASSSTVTED ECCCCCCCCCCCCCC	19.24	-
512	Ubiquitination	KVLCETVKDFVARVG HHHHHHHHHHHHHHH	53.52	-
524	Ubiquitination	RVGKAYEKTTESSEE HHHHHHHHCCCCHHH	48.33	-
545	Ubiquitination	KCSVLKEKLDSLLKT HHHHHHHHHHHHHHH	56.88	-
548	Phosphorylation	VLKEKLDSLLKTLDD HHHHHHHHHHHHCCC	46.14	24719451
615	Phosphorylation	QLMLRANSLKKAIRQ HHHHHHHHHHHHHHH	40.35	24719451
664	Phosphorylation	HRVCPPLSHSESFGV CCCCCCCCCHHHCCC	30.64	25159151
666	Phosphorylation	VCPPLSHSESFGVPK CCCCCCCHHHCCCCC	31.40	25159151
668	Phosphorylation	PPLSHSESFGVPKGR CCCCCHHHCCCCCCC	30.25	25159151
681	O-linked_Glycosylation	GRSQRKVSKSPCEKL CCCCCCCCCCHHHHH	30.37	30379171
681	Phosphorylation	GRSQRKVSKSPCEKL CCCCCCCCCCHHHHH	30.37	28060719
683	Phosphorylation	SQRKVSKSPCEKLIS CCCCCCCCHHHHHHH	27.55	28060719
687	Ubiquitination	VSKSPCEKLISKGSL CCCCHHHHHHHCCCC	58.81	-
691	Ubiquitination	PCEKLISKGSLSLGS HHHHHHHCCCCCCCC	45.59	-
718	Ubiquitination	GLPALNTKILYPNVR CCCCCCCEEECCCCC	29.64	-
721	Phosphorylation	ALNTKILYPNVRAGM CCCCEEECCCCCCCC	9.02	27642862
729	Phosphorylation	PNVRAGMSGSLPGGS CCCCCCCCCCCCCCC	25.06	25404012
731	Phosphorylation	VRAGMSGSLPGGSVI CCCCCCCCCCCCCHH	24.88	28348404
736	Phosphorylation	SGSLPGGSVISRLLI CCCCCCCCHHHHHEE	23.38	28555341
739	Phosphorylation	LPGGSVISRLLINAD CCCCCHHHHHEECCC	18.08	25404012
757	Phosphorylation	SEPETLEYYTEKCVM CCCHHHHHHHHHHHH	20.85	-
783	Ubiquitination	ISLDFNNKRDEHPEK EEEECCCCCCCCHHH	63.43	-
813	Phosphorylation	TKELLHRTYKNLEQK HHHHHHHHHCCHHHC	28.27	29457462
815	Ubiquitination	ELLHRTYKNLEQKVL HHHHHHHCCHHHCEE	55.21	-
950	Ubiquitination	RAFESTLKSWEDKQK HHHHHHHHHHHHHHC	54.32	-
965	Phosphorylation	CELPRPPSCSLHPEM CCCCCCCCCCCCHHH	21.01	28348404
967	Phosphorylation	LPRPPSCSLHPEMLS CCCCCCCCCCHHHCC	33.77	28348404
994	Phosphorylation	AAGVLIHSIREIAQS HHHHHHHHHHHHHHH	19.15	24719451
1057	Phosphorylation	SETELLLSGKMALQL CHHHHHHHCCEECCC	36.02	-
1185	Ubiquitination	HLERRDLKDLGVTKV EEEHHCHHHCCCCCH	56.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
66	S	Phosphorylation	Kinase	KPCA	P17252	PhosphoELM
66	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
70	S	Phosphorylation	Kinase	KPCA	P17252	PhosphoELM
70	S	Phosphorylation	Kinase	PRKCA	P05696	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DGKD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DGKD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAX1_HUMAN	HAX1	physical	16169070
IGS21_HUMAN	IGSF21	physical	16169070
DGKD_HUMAN	DGKD	physical	12200442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00144: Phosphatidylserine