DI3L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DI3L1_HUMAN
• UniProt AC: Q8TF46
• Protein Name: DIS3-like exonuclease 1
• Gene Name: DIS3L
• Organism: Homo sapiens (Human).
• Sequence Length: 1054
• Subcellular Localization: Cytoplasm .
• Protein Description: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA..
• Protein Sequence: MLQKREKVLLLRTFQGRTLRIVREHYLRPCVPCHSPLCPQPAACSHDGKLLSSDVTHYVIPDWKVVQDYLEILEFPELKGIIFMQTACQAVQHQRGRRQYNKLRNLLKDARHDCILFANEFQQCCYLPRERGESMEKWQTRSIYNAAVWYYHHCQDRMPIVMVTEDEEAIQQYGSETEGVFVITFKNYLDNFWPDLKAAHELCDSILQSRRERENESQESHGKEYPEHLPLEVLEAGIKSGRYIQGILNVNKHRAQIEAFVRLQGASSKDSDLVSDILIHGMKARNRSIHGDVVVVELLPKNEWKGRTVALCENDCDDKASGESPSEPMPTGRVVGILQKNWRDYVVTFPSKEEVQSQGKNAQKILVTPWDYRIPKIRISTQQAETLQDFRVVVRIDSWESTSVYPNGHFVRVLGRIGDLEGEIATILVENSISVIPFSEAQMCEMPVNTPESPWKVSPEEEQKRKDLRKSHLVFSIDPKGCEDVDDTLSVRTLNNGNLELGVHIADVTHFVAPNSYIDIEARTRATTYYLADRRYDMLPSVLSADLCSLLGGVDRYAVSIMWELDKASYEIKKVWYGRTIIRSAYKLFYEAAQELLDGNLSVVDDIPEFKDLDEKSRQAKLEELVWAIGKLTDIARHVRAKRDGCGALELEGVEVCVQLDDKKNIHDLIPKQPLEVHETVAECMILANHWVAKKIWESFPHQALLRQHPPPHQEFFSELRECAKAKGFFIDTRSNKTLADSLDNANDPHDPIVNRLLRSMATQAMSNALYFSTGSCAEEEFHHYGLALDKYTHFTSPIRRYSDIVVHRLLMAAISKDKKMEIKGNLFSNKDLEELCRHINNRNQAAQHSQKQSTELFQCMYFKDKDPATEERCISDGVIYSIRTNGVLLFIPRFGIKGAAYLKNKDGLVISCGPDSCSEWKPGSLQRFQNKITSTTTDGESVTFHLFDHVTVRISIQASRCHSDTIRLEIISNKPYKIPNTELIHQSSPLLKSELVKEVTKSVEEAQLAQEVKVNIIQEEYQEYRQTKGRSLYTLLEEIRDLALLDVSNNYGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Ubiquitination	TLRIVREHYLRPCVP EEHHHHHHHCCCCCC	19.16	33845483
89	Ubiquitination	IFMQTACQAVQHQRG EEHHHHHHHHHHHHH	41.95	29967540
91	Ubiquitination	MQTACQAVQHQRGRR HHHHHHHHHHHHHHH	1.84	33845483
97	Ubiquitination	AVQHQRGRRQYNKLR HHHHHHHHHHHHHHH	25.39	29967540
105	Ubiquitination	RQYNKLRNLLKDARH HHHHHHHHHHHHHHC	61.23	29967540
108	Ubiquitination	NKLRNLLKDARHDCI HHHHHHHHHHHCCCE	53.13	33845483
113	Ubiquitination	LLKDARHDCILFANE HHHHHHCCCEEEECC	18.65	29967540
137	Ubiquitination	ERGESMEKWQTRSIY HHCCCHHHHHHHHHH	35.64	-
140	Ubiquitination	ESMEKWQTRSIYNAA CCHHHHHHHHHHHHH	25.85	29967540
149	Ubiquitination	SIYNAAVWYYHHCQD HHHHHHHHHHHHCCC	5.35	21963094
149 (in isoform 2)	Ubiquitination	-	5.35	21906983
156	Ubiquitination	WYYHHCQDRMPIVMV HHHHHCCCCCCEEEE	54.99	29967540
157	Ubiquitination	YYHHCQDRMPIVMVT HHHHCCCCCCEEEEE	13.60	21963094
163	Ubiquitination	DRMPIVMVTEDEEAI CCCCEEEEECCHHHH	3.52	29967540
179	Ubiquitination	QYGSETEGVFVITFK HHCCCCCCEEEEEEC	26.11	29967540
185	Ubiquitination	EGVFVITFKNYLDNF CCEEEEEECCHHHHC	3.12	21963094
193	Ubiquitination	KNYLDNFWPDLKAAH CCHHHHCCHHHHHHH	7.55	21963094
200	Ubiquitination	WPDLKAAHELCDSIL CHHHHHHHHHHHHHH	33.16	21963094
200 (in isoform 4)	Ubiquitination	-	33.16	21906983
206	Ubiquitination	AHELCDSILQSRRER HHHHHHHHHHHHHHH	2.31	29967540
214	Ubiquitination	LQSRRERENESQESH HHHHHHHHHHHHHHC	61.67	29967540
218	Ubiquitination	RERENESQESHGKEY HHHHHHHHHHCCCCC	50.46	22817900
218 (in isoform 2)	Ubiquitination	-	50.46	21906983
222	Ubiquitination	NESQESHGKEYPEHL HHHHHHCCCCCCCCC	33.50	29967540
223	Ubiquitination	ESQESHGKEYPEHLP HHHHHCCCCCCCCCC	48.96	21963094
226	Ubiquitination	ESHGKEYPEHLPLEV HHCCCCCCCCCCHHH	24.50	21963094
230	Ubiquitination	KEYPEHLPLEVLEAG CCCCCCCCHHHHHHH	28.51	22817900
234	Ubiquitination	EHLPLEVLEAGIKSG CCCCHHHHHHHHHCC	2.45	21963094
236	Ubiquitination	LPLEVLEAGIKSGRY CCHHHHHHHHHCCCC	22.35	21963094
238	Ubiquitination	LEVLEAGIKSGRYIQ HHHHHHHHHCCCCEE	4.07	22817900
239	Ubiquitination	EVLEAGIKSGRYIQG HHHHHHHHCCCCEEE	46.04	29967540
252	Ubiquitination	QGILNVNKHRAQIEA EEEEECCHHHHHHHH	30.13	-
257	Ubiquitination	VNKHRAQIEAFVRLQ CCHHHHHHHHHHHHC	3.94	29967540
259	Ubiquitination	KHRAQIEAFVRLQGA HHHHHHHHHHHHCCC	15.18	21963094
266	Ubiquitination	AFVRLQGASSKDSDL HHHHHCCCCCCCCCH	9.54	21963094
269	Ubiquitination	RLQGASSKDSDLVSD HHCCCCCCCCCHHHH	59.77	22817900
269 (in isoform 4)	Ubiquitination	-	59.77	21906983
277	Ubiquitination	DSDLVSDILIHGMKA CCCHHHHHHHCHHHH	2.79	21963094
280	Ubiquitination	LVSDILIHGMKARNR HHHHHHHCHHHHCCC	27.18	29967540
281	Ubiquitination	VSDILIHGMKARNRS HHHHHHCHHHHCCCC	16.58	22817900
283	Ubiquitination	DILIHGMKARNRSIH HHHHCHHHHCCCCCC	49.11	21906983
283 (in isoform 1)	Ubiquitination	-	49.11	21906983
283 (in isoform 3)	Ubiquitination	-	49.11	21906983
292	Ubiquitination	RNRSIHGDVVVVELL CCCCCCCCEEEEEEC	18.84	22817900
300	Ubiquitination	VVVVELLPKNEWKGR EEEEEECCCCCCCCC	50.48	21963094
302	Ubiquitination	VVELLPKNEWKGRTV EEEECCCCCCCCCEE	59.42	21963094
304	Ubiquitination	ELLPKNEWKGRTVAL EECCCCCCCCCEEEE	20.14	22817900
319	Ubiquitination	CENDCDDKASGESPS ECCCCCCCCCCCCCC	31.07	21963094
323	Ubiquitination	CDDKASGESPSEPMP CCCCCCCCCCCCCCC	57.91	29967540
335	Ubiquitination	PMPTGRVVGILQKNW CCCCCCEEEEEECCC	3.67	22817900
336	Ubiquitination	MPTGRVVGILQKNWR CCCCCEEEEEECCCC	16.42	29967540
340	Ubiquitination	RVVGILQKNWRDYVV CEEEEEECCCCEEEE	55.84	29967540
343	Ubiquitination	GILQKNWRDYVVTFP EEEECCCCEEEEECC	34.47	21963094
344	Ubiquitination	ILQKNWRDYVVTFPS EEECCCCEEEEECCC	31.99	29967540
345	Phosphorylation	LQKNWRDYVVTFPSK EECCCCEEEEECCCH	6.56	25278378
347	Ubiquitination	KNWRDYVVTFPSKEE CCCCEEEEECCCHHH	3.58	22817900
348	Phosphorylation	NWRDYVVTFPSKEEV CCCEEEEECCCHHHH	21.56	24076635
351	Phosphorylation	DYVVTFPSKEEVQSQ EEEEECCCHHHHHHC	48.81	25278378
352	Ubiquitination	YVVTFPSKEEVQSQG EEEECCCHHHHHHCC	59.12	22817900
352 (in isoform 1)	Ubiquitination	-	59.12	21906983
352 (in isoform 3)	Ubiquitination	-	59.12	21906983
357	Phosphorylation	PSKEEVQSQGKNAQK CCHHHHHHCCCCCCE	46.18	24076635
360	Ubiquitination	EEVQSQGKNAQKILV HHHHHCCCCCCEEEE	41.28	21963094
364	Ubiquitination	SQGKNAQKILVTPWD HCCCCCCEEEECCCC	35.28	22817900
368	Phosphorylation	NAQKILVTPWDYRIP CCCEEEECCCCCCCC	18.41	21406692
372	Phosphorylation	ILVTPWDYRIPKIRI EEECCCCCCCCEEEE	13.43	21406692
387	Ubiquitination	STQQAETLQDFRVVV EHHCCCCCCCCEEEE	3.28	29967540
410	Ubiquitination	SVYPNGHFVRVLGRI EECCCCCEEEEEEEE	3.88	29967540
453	Ubiquitination	MPVNTPESPWKVSPE CCCCCCCCCCCCCHH	36.95	29967540
458	Phosphorylation	PESPWKVSPEEEQKR CCCCCCCCHHHHHHH	23.90	30266825
470	Ubiquitination	QKRKDLRKSHLVFSI HHHHHHHHHCEEEEE	49.91	29967540
471	Phosphorylation	KRKDLRKSHLVFSID HHHHHHHHCEEEEEC	18.67	-
480	Ubiquitination	LVFSIDPKGCEDVDD EEEEECCCCCCCCCC	72.88	-
536	Phosphorylation	YYLADRRYDMLPSVL HHHCCCCCCCCHHHH	13.44	27251275
544	Phosphorylation	DMLPSVLSADLCSLL CCCHHHHHHHHHHHH	19.99	27251275
581	Acetylation	KVWYGRTIIRSAYKL HHHHHHHHHHHHHHH	2.07	19413330
603	Ubiquitination	LLDGNLSVVDDIPEF HHCCCCCEECCCCCC	6.53	29967540
611	Ubiquitination	VDDIPEFKDLDEKSR ECCCCCCCCCCHHHH	56.57	29967540
654	Ubiquitination	GALELEGVEVCVQLD CCEEEECEEEEEECC	3.48	29967540
664	Acetylation	CVQLDDKKNIHDLIP EEECCCCCCHHHHCC	69.04	19413330
677	Ubiquitination	IPKQPLEVHETVAEC CCCCCCCCCHHHHHH	6.96	29967540
690	Ubiquitination	ECMILANHWVAKKIW HHHHHHHHHHHHHHH	18.12	29967540
695	Ubiquitination	ANHWVAKKIWESFPH HHHHHHHHHHHHCCH	43.23	-
697	Ubiquitination	HWVAKKIWESFPHQA HHHHHHHHHHCCHHH	12.22	29967540
698	Ubiquitination	WVAKKIWESFPHQAL HHHHHHHHHCCHHHH	46.07	29967540
705	Ubiquitination	ESFPHQALLRQHPPP HHCCHHHHHHHCCCC	3.05	29967540
718	Phosphorylation	PPHQEFFSELRECAK CCHHHHHHHHHHHHH	40.83	24719451
720	Ubiquitination	HQEFFSELRECAKAK HHHHHHHHHHHHHHC	5.60	29967540
727	Ubiquitination	LRECAKAKGFFIDTR HHHHHHHCCEEEECC	56.39	-
737	Ubiquitination	FIDTRSNKTLADSLD EEECCCCCCHHHHCC	46.27	29967540
741	Ubiquitination	RSNKTLADSLDNAND CCCCCHHHHCCCCCC	53.50	29967540
748	Ubiquitination	DSLDNANDPHDPIVN HHCCCCCCCCCHHHH	39.23	29967540
764	Ubiquitination	LLRSMATQAMSNALY HHHHHHHHHHHHCHH	26.06	29967540
770	Ubiquitination	TQAMSNALYFSTGSC HHHHHHCHHHCCCCC	5.33	29967540
771	Ubiquitination	QAMSNALYFSTGSCA HHHHHCHHHCCCCCC	7.96	29967540
772	Ubiquitination	AMSNALYFSTGSCAE HHHHCHHHCCCCCCH	5.69	29967540
778	Ubiquitination	YFSTGSCAEEEFHHY HHCCCCCCHHHHHHH	29.00	29967540
780	Ubiquitination	STGSCAEEEFHHYGL CCCCCCHHHHHHHHC	47.65	29967540
788	Ubiquitination	EFHHYGLALDKYTHF HHHHHHCHHHHCCCC	14.89	29967540
796	Ubiquitination	LDKYTHFTSPIRRYS HHHCCCCCCCCHHHH	26.45	29967540
802	Phosphorylation	FTSPIRRYSDIVVHR CCCCCHHHHHHHHHH	10.80	-
803	Phosphorylation	TSPIRRYSDIVVHRL CCCCHHHHHHHHHHH	21.03	-
807	Ubiquitination	RRYSDIVVHRLLMAA HHHHHHHHHHHHHHH	1.91	29967540
814	Ubiquitination	VHRLLMAAISKDKKM HHHHHHHHHCCCCCC	7.82	29967540
821	Ubiquitination	AISKDKKMEIKGNLF HHCCCCCCCEECCCC	8.73	29967540
823	Ubiquitination	SKDKKMEIKGNLFSN CCCCCCCEECCCCCC	6.56	29967540
824	Ubiquitination	KDKKMEIKGNLFSNK CCCCCCEECCCCCCC	28.56	29967540
829	Phosphorylation	EIKGNLFSNKDLEEL CEECCCCCCCCHHHH	46.25	21955146
831	Ubiquitination	KGNLFSNKDLEELCR ECCCCCCCCHHHHHH	63.59	29967540
839	Ubiquitination	DLEELCRHINNRNQA CHHHHHHHHHHHHHH	26.57	29967540
844	Ubiquitination	CRHINNRNQAAQHSQ HHHHHHHHHHHHHHH	37.66	29967540
846	Ubiquitination	HINNRNQAAQHSQKQ HHHHHHHHHHHHHHH	16.79	29967540
862	Ubiquitination	TELFQCMYFKDKDPA HHHHHHHHCCCCCCC	18.33	29967540
864	Ubiquitination	LFQCMYFKDKDPATE HHHHHHCCCCCCCCC	46.51	29967540
868	Ubiquitination	MYFKDKDPATEERCI HHCCCCCCCCCCEEC	46.99	29967540
872	Ubiquitination	DKDPATEERCISDGV CCCCCCCCEECCCCE	48.80	29967540
876	Ubiquitination	ATEERCISDGVIYSI CCCCEECCCCEEEEE	31.75	29967540
881	Phosphorylation	CISDGVIYSIRTNGV ECCCCEEEEEECCCE	8.81	-
882	Phosphorylation	ISDGVIYSIRTNGVL CCCCEEEEEECCCEE	8.41	24719451
887	Ubiquitination	IYSIRTNGVLLFIPR EEEEECCCEEEEEEC	15.73	29967540
889	Ubiquitination	SIRTNGVLLFIPRFG EEECCCEEEEEECCC	3.24	29967540
898	Ubiquitination	FIPRFGIKGAAYLKN EEECCCCCCCEEEEC	42.76	-
904	Ubiquitination	IKGAAYLKNKDGLVI CCCCEEEECCCEEEE	49.64	29967540
905	Ubiquitination	KGAAYLKNKDGLVIS CCCEEEECCCEEEEE	45.09	29967540
906	Acetylation	GAAYLKNKDGLVISC CCEEEECCCEEEEEE	52.14	26051181
906	Ubiquitination	GAAYLKNKDGLVISC CCEEEECCCEEEEEE	52.14	29967540
915	Ubiquitination	GLVISCGPDSCSEWK EEEEEECCCCCCCCC	34.37	29967540
919	Ubiquitination	SCGPDSCSEWKPGSL EECCCCCCCCCCCCH	50.90	29967540
922	Ubiquitination	PDSCSEWKPGSLQRF CCCCCCCCCCCHHHH	35.13	29967540
938	Ubiquitination	NKITSTTTDGESVTF CEECEECCCCCEEEE	41.94	29967540
942	Ubiquitination	STTTDGESVTFHLFD EECCCCCEEEEEECC	31.80	29967540
981	Ubiquitination	NKPYKIPNTELIHQS CCCCCCCCCHHCCCC	50.05	29967540
982	Phosphorylation	KPYKIPNTELIHQSS CCCCCCCCHHCCCCC	27.15	23312004
985	Ubiquitination	KIPNTELIHQSSPLL CCCCCHHCCCCCHHH	1.95	29967540
988	Phosphorylation	NTELIHQSSPLLKSE CCHHCCCCCHHHHHH	21.54	25159151
989	Phosphorylation	TELIHQSSPLLKSEL CHHCCCCCHHHHHHH	17.01	25159151
998	Ubiquitination	LLKSELVKEVTKSVE HHHHHHHHHHHHHHH	60.12	29967540
1001	Phosphorylation	SELVKEVTKSVEEAQ HHHHHHHHHHHHHHH	20.77	-
1002	Ubiquitination	ELVKEVTKSVEEAQL HHHHHHHHHHHHHHH	58.65	29967540
1022	Phosphorylation	VNIIQEEYQEYRQTK HHHHHHHHHHHHHCC	13.09	23312004
1025	Phosphorylation	IQEEYQEYRQTKGRS HHHHHHHHHHCCCCC	7.78	27642862
1028	Phosphorylation	EYQEYRQTKGRSLYT HHHHHHHCCCCCHHH	26.85	22496350
1032	Phosphorylation	YRQTKGRSLYTLLEE HHHCCCCCHHHHHHH	34.10	27642862
1034	Phosphorylation	QTKGRSLYTLLEEIR HCCCCCHHHHHHHHH	9.15	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DI3L1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DI3L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DI3L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXOS7_HUMAN	EXOSC7	physical	20531386
EXOS4_HUMAN	EXOSC4	physical	20531386
EXOS9_HUMAN	EXOSC9	physical	20531386
EXOS3_HUMAN	EXOSC3	physical	20531386
EXOS5_HUMAN	EXOSC5	physical	20531386
EXOS8_HUMAN	EXOSC8	physical	20531386
EXOS1_HUMAN	EXOSC1	physical	20531386
EXOS2_HUMAN	EXOSC2	physical	20531386
SK2L2_HUMAN	SKIV2L2	physical	20531386
EXOSX_HUMAN	EXOSC10	physical	20531386
EXOS6_HUMAN	EXOSC6	physical	20531386
GGYF2_HUMAN	GIGYF2	physical	20531386
ZN598_HUMAN	ZNF598	physical	20531386
IF4E2_HUMAN	EIF4E2	physical	20531386
HBS1L_HUMAN	HBS1L	physical	20531386
EXOS2_HUMAN	EXOSC2	physical	20531389
H2AX_HUMAN	H2AFX	physical	26496610
EXOS9_HUMAN	EXOSC9	physical	26496610
EXOSX_HUMAN	EXOSC10	physical	26496610
RU17_HUMAN	SNRNP70	physical	26496610
HBS1L_HUMAN	HBS1L	physical	26496610
SRCAP_HUMAN	SRCAP	physical	26496610
EXOS8_HUMAN	EXOSC8	physical	26496610
EXOS2_HUMAN	EXOSC2	physical	26496610
GGYF2_HUMAN	GIGYF2	physical	26496610
EXOS3_HUMAN	EXOSC3	physical	26496610
EXOS4_HUMAN	EXOSC4	physical	26496610
EXOS5_HUMAN	EXOSC5	physical	26496610
EXOS6_HUMAN	EXOSC6	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.