ETV3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ETV3_MOUSE
• UniProt AC: Q8R4Z4
• Protein Name: ETS translocation variant 3
• Gene Name: Etv3
• Organism: Mus musculus (Mouse).
• Sequence Length: 513
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity..
• Protein Sequence: MKAGCSIVEKPEGGGGYQFPDWAYKAESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVMPNYPFINIRSSGVVPQSAPPVPTASSRFHFPPLDSHSPTGDVQPGRFSASSLSASGPESGVTTDRKVEPSDLEDGSASDWHRGMDFMPSRNALGGGAVGHQKRKPDILLPLFTRPAMYPDPHSPFAISPVPGRGGVLNVPISPALSLTPTMFSYSPSPGLSPFTSSSCFSFNPEEMKHYLHSQACSVFNYHLSPRTFPRYPGLMVPPLQCQMHPEEPSQFSIKLQPPPAGRKNRERVESREEAVRGSVPASAPVPSRIKVEPATEKDPDSLRQSTQGKEEQTQEVDSMRSRTIEEGKGTGFAHPSPTWPSVSISTPSDEPLEGTEDSEDRSVREPGVPEKKEDALMPPKLRLKRRWNDDPEARELNKTGKFLWNGAGPQGLATTATAAADA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
132	Phosphorylation	YPFINIRSSGVVPQS CCEEEEECCCCCCCC	27.87	25619855
133	Phosphorylation	PFINIRSSGVVPQSA CEEEEECCCCCCCCC	26.26	25619855
139	Phosphorylation	SSGVVPQSAPPVPTA CCCCCCCCCCCCCCC	36.35	25521595
145	Phosphorylation	QSAPPVPTASSRFHF CCCCCCCCCCCCCCC	39.13	25619855
147	Phosphorylation	APPVPTASSRFHFPP CCCCCCCCCCCCCCC	25.23	25619855
148	Phosphorylation	PPVPTASSRFHFPPL CCCCCCCCCCCCCCC	36.18	25619855
157	Phosphorylation	FHFPPLDSHSPTGDV CCCCCCCCCCCCCCC	33.28	22942356
159	Phosphorylation	FPPLDSHSPTGDVQP CCCCCCCCCCCCCCC	28.27	22942356
161	Phosphorylation	PLDSHSPTGDVQPGR CCCCCCCCCCCCCCC	49.37	28833060
170	Phosphorylation	DVQPGRFSASSLSAS CCCCCCCCCHHCCCC	26.36	28066266
172	Phosphorylation	QPGRFSASSLSASGP CCCCCCCHHCCCCCC	30.52	28066266
173	Phosphorylation	PGRFSASSLSASGPE CCCCCCHHCCCCCCC	26.51	28066266
175	Phosphorylation	RFSASSLSASGPESG CCCCHHCCCCCCCCC	23.49	25266776
177	Phosphorylation	SASSLSASGPESGVT CCHHCCCCCCCCCCC	52.05	28066266
181	Phosphorylation	LSASGPESGVTTDRK CCCCCCCCCCCCCCC	41.52	28066266
184	Phosphorylation	SGPESGVTTDRKVEP CCCCCCCCCCCCCCH	26.89	28066266
185	Phosphorylation	GPESGVTTDRKVEPS CCCCCCCCCCCCCHH	31.25	28066266
198	Phosphorylation	PSDLEDGSASDWHRG HHHCCCCCCCHHHCC	36.60	25338131
200	Phosphorylation	DLEDGSASDWHRGMD HCCCCCCCHHHCCCC	42.82	25266776
240	Phosphorylation	LFTRPAMYPDPHSPF CCCCCCCCCCCCCCC	13.44	29472430
245	Phosphorylation	AMYPDPHSPFAISPV CCCCCCCCCCEEECC	27.40	23684622
250	Phosphorylation	PHSPFAISPVPGRGG CCCCCEEECCCCCCC	19.20	23684622
264	Phosphorylation	GVLNVPISPALSLTP CCCCCCCCCCCCCCC	9.69	23608596
312	Phosphorylation	QACSVFNYHLSPRTF CCCHHHCCCCCCCCC	7.83	23984901
315	Phosphorylation	SVFNYHLSPRTFPRY HHHCCCCCCCCCCCC	10.06	25266776
361	Phosphorylation	KNRERVESREEAVRG CCHHHHHHHHHHHCC	41.98	25266776
369	Phosphorylation	REEAVRGSVPASAPV HHHHHCCCCCCCCCC	17.86	23567750
373	Phosphorylation	VRGSVPASAPVPSRI HCCCCCCCCCCCCCE	27.34	23567750
378	Phosphorylation	PASAPVPSRIKVEPA CCCCCCCCCEEEEEC	47.04	23567750
388	Acetylation	KVEPATEKDPDSLRQ EEEECCCCCHHHHHH	70.92	-
414	Phosphorylation	VDSMRSRTIEEGKGT HHHHHCCCHHCCCCC	33.71	30635358
421	Phosphorylation	TIEEGKGTGFAHPSP CHHCCCCCCCCCCCC	32.39	25619855
427	Phosphorylation	GTGFAHPSPTWPSVS CCCCCCCCCCCCCEE	25.70	25619855
429	Phosphorylation	GFAHPSPTWPSVSIS CCCCCCCCCCCEEEE	55.11	25619855
432	Phosphorylation	HPSPTWPSVSISTPS CCCCCCCCEEEECCC	21.76	25619855
434	Phosphorylation	SPTWPSVSISTPSDE CCCCCCEEEECCCCC	18.37	25619855
436	Phosphorylation	TWPSVSISTPSDEPL CCCCEEEECCCCCCC	27.10	30635358
437	Phosphorylation	WPSVSISTPSDEPLE CCCEEEECCCCCCCC	25.74	25619855
439	Phosphorylation	SVSISTPSDEPLEGT CEEEECCCCCCCCCC	55.48	30635358
446	Phosphorylation	SDEPLEGTEDSEDRS CCCCCCCCCCCCCCC	27.52	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
139	S	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ETV3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ETV3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDX20_MOUSE	Ddx20	physical	12007404

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.