DDX20_MOUSE - dbPTM
DDX20_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DDX20_MOUSE
UniProt AC Q9JJY4
Protein Name Probable ATP-dependent RNA helicase DDX20
Gene Name Ddx20
Organism Mus musculus (Mouse).
Sequence Length 825
Subcellular Localization Cytoplasm. Nucleus, gem. Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).
Protein Description The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs) (By similarity)..
Protein Sequence MAAAAFEVPAALTTSESTMAAERAAAPVQAVEPTPASPWTQRTAHDIGGPRTRTGDVVLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRLNPSDPSLIGLKQYYQVVNSYPLAHKIFEEKTQHLQELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMKIAQKCNINLLPLPDPIPPGLMEECLNWDVEVKAAMHTYSSPTVATQSPKKQVQKLERAFQSQRTPGNQTPSPRNTSASALSARPKHSKPKLPVKSHSECGVLEKAAPPQESGCPAQLEEQVKNSVQTSVEDSSSNSQHQAKDSSPGSLPKIPCLSSFKVHQPSTLTFAELVDDYEHYIKEGLEKPVEIIRHYTGPEAQTGNPQNGFVRNRVSEDRAQMLVSSSQSGDSESDSDSCSSRTSSQSKGNKSYLEGSSDTQLKDTECTPVGGPLSLEQVQNGNDTPTQVEYQEAPETQVKARHKEGANQRSKQSRRNPARRSSYRVQSEPQEESWYDCHRETTASFSDTYQDYEEYWRAYYRAWQEYYAAASHSYYWNAQRHPSWMAAYHMNTVYLQEMMRGNQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationVPAALTTSESTMAAE
CCEECCCCHHHHHHH		25.0625338131
34PhosphorylationPVQAVEPTPASPWTQ
CCCCCCCCCCCCCCC		20.2728066266
37PhosphorylationAVEPTPASPWTQRTA
CCCCCCCCCCCCCCH		23.3625619855
40PhosphorylationPTPASPWTQRTAHDI
CCCCCCCCCCCHHHC		16.1428066266
87PhosphorylationAAGFERPSPVQLKAI
HCCCCCCCCCEEEEE		43.8826239621
188PhosphorylationKCHIAVGSPGRIKQL
CCEEECCCCCHHHHH		19.99-
270PhosphorylationTFVRLNPSDPSLIGL
CEEECCCCCHHHCCH		62.17-
280PhosphorylationSLIGLKQYYQVVNSY
HHCCHHHHHHHHHHH		8.3523737553
281PhosphorylationLIGLKQYYQVVNSYP
HCCHHHHHHHHHHHH		7.7323737553
286PhosphorylationQYYQVVNSYPLAHKI
HHHHHHHHHHHHHHH		19.2723737553
287PhosphorylationYYQVVNSYPLAHKIF
HHHHHHHHHHHHHHH		9.3223737553
462PhosphorylationEVKAAMHTYSSPTVA
HHHHHHHHCCCCCCC		16.4125159016
463PhosphorylationVKAAMHTYSSPTVAT
HHHHHHHCCCCCCCC		7.7725619855
464PhosphorylationKAAMHTYSSPTVATQ
HHHHHHCCCCCCCCC		30.8825619855
465PhosphorylationAAMHTYSSPTVATQS
HHHHHCCCCCCCCCC		17.7421082442
467PhosphorylationMHTYSSPTVATQSPK
HHHCCCCCCCCCCHH		25.4025619855
470PhosphorylationYSSPTVATQSPKKQV
CCCCCCCCCCHHHHH		25.8325521595
472PhosphorylationSPTVATQSPKKQVQK
CCCCCCCCHHHHHHH		34.0426824392
489PhosphorylationRAFQSQRTPGNQTPS
HHHHHCCCCCCCCCC		28.1024759943
494PhosphorylationQRTPGNQTPSPRNTS
CCCCCCCCCCCCCCC		29.7225159016
496PhosphorylationTPGNQTPSPRNTSAS
CCCCCCCCCCCCCHH		39.6225521595
500PhosphorylationQTPSPRNTSASALSA
CCCCCCCCCHHHHHC		27.2728066266
501PhosphorylationTPSPRNTSASALSAR
CCCCCCCCHHHHHCC		24.6328066266
503PhosphorylationSPRNTSASALSARPK
CCCCCCHHHHHCCCC		29.5228066266
506PhosphorylationNTSASALSARPKHSK
CCCHHHHHCCCCCCC		23.1926643407
520PhosphorylationKPKLPVKSHSECGVL
CCCCCCCCHHCCCCC		32.2629899451
522PhosphorylationKLPVKSHSECGVLEK
CCCCCCHHCCCCCCC		41.4925266776
549PhosphorylationLEEQVKNSVQTSVED
HHHHHHHHHHHCCCC		15.1930635358
552PhosphorylationQVKNSVQTSVEDSSS
HHHHHHHHCCCCCCC		32.3630635358
553PhosphorylationVKNSVQTSVEDSSSN
HHHHHHHCCCCCCCC		13.3530635358
557PhosphorylationVQTSVEDSSSNSQHQ
HHHCCCCCCCCCCCC		23.3525266776
558PhosphorylationQTSVEDSSSNSQHQA
HHCCCCCCCCCCCCC		45.9530635358
559PhosphorylationTSVEDSSSNSQHQAK
HCCCCCCCCCCCCCC		44.4430635358
561PhosphorylationVEDSSSNSQHQAKDS
CCCCCCCCCCCCCCC		30.8725168779
568PhosphorylationSQHQAKDSSPGSLPK
CCCCCCCCCCCCCCC		37.4125159016
569PhosphorylationQHQAKDSSPGSLPKI
CCCCCCCCCCCCCCC		43.3327087446
572PhosphorylationAKDSSPGSLPKIPCL
CCCCCCCCCCCCCCC		44.9025159016
653PhosphorylationSSSQSGDSESDSDSC
HHCCCCCCCCCCCCC		42.39-
655PhosphorylationSQSGDSESDSDSCSS
CCCCCCCCCCCCCCC		46.49-
657PhosphorylationSGDSESDSDSCSSRT
CCCCCCCCCCCCCCC		40.48-
665PhosphorylationDSCSSRTSSQSKGNK
CCCCCCCCCCCCCCH		25.8530635358
666PhosphorylationSCSSRTSSQSKGNKS
CCCCCCCCCCCCCHH		37.5530635358
668PhosphorylationSSRTSSQSKGNKSYL
CCCCCCCCCCCHHHC		44.4730635358
673PhosphorylationSQSKGNKSYLEGSSD
CCCCCCHHHCCCCCC		38.6625521595
674PhosphorylationQSKGNKSYLEGSSDT
CCCCCHHHCCCCCCC		15.4725619855
678PhosphorylationNKSYLEGSSDTQLKD
CHHHCCCCCCCCCCC		18.7027087446
679PhosphorylationKSYLEGSSDTQLKDT
HHHCCCCCCCCCCCC		56.3825521595
681PhosphorylationYLEGSSDTQLKDTEC
HCCCCCCCCCCCCCC		37.4427087446
686PhosphorylationSDTQLKDTECTPVGG
CCCCCCCCCCCCCCC		31.2226745281
689PhosphorylationQLKDTECTPVGGPLS
CCCCCCCCCCCCCCC		18.1226745281
696PhosphorylationTPVGGPLSLEQVQNG
CCCCCCCCHHHHHCC		32.7525293948
706PhosphorylationQVQNGNDTPTQVEYQ
HHHCCCCCCCEEEEE		32.0325521595
708PhosphorylationQNGNDTPTQVEYQEA
HCCCCCCCEEEEECC		47.5425293948
712PhosphorylationDTPTQVEYQEAPETQ
CCCCEEEEECCCHHH		16.8825293948
743PhosphorylationRRNPARRSSYRVQSE
HCCCCHHHHCCCCCC		26.6023984901
744PhosphorylationRNPARRSSYRVQSEP
CCCCHHHHCCCCCCC		18.3625266776
745PhosphorylationNPARRSSYRVQSEPQ
CCCHHHHCCCCCCCC		18.9523984901
749PhosphorylationRSSYRVQSEPQEESW
HHHCCCCCCCCCCCC		48.6825266776
755PhosphorylationQSEPQEESWYDCHRE
CCCCCCCCCHHHCCC		30.1328066266
757PhosphorylationEPQEESWYDCHRETT
CCCCCCCHHHCCCCC		20.2622817900
763PhosphorylationWYDCHRETTASFSDT
CHHHCCCCCCCCCHH		27.8425367039
764PhosphorylationYDCHRETTASFSDTY
HHHCCCCCCCCCHHH		18.6225367039
766PhosphorylationCHRETTASFSDTYQD
HCCCCCCCCCHHHHC		24.1625367039
768PhosphorylationRETTASFSDTYQDYE
CCCCCCCCHHHHCHH		26.9225367039
770PhosphorylationTTASFSDTYQDYEEY
CCCCCCHHHHCHHHH		23.1425367039
788PhosphorylationYYRAWQEYYAAASHS
HHHHHHHHHHHHHCC		5.3622817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DDX20_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DDX20_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DDX20_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ETV3_MOUSEEtv3physical
12007404
NCOR2_MOUSENcor2physical
12007404
SIN3A_MOUSESin3aphysical
12007404
HDAC2_MOUSEHdac2physical
12007404
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DDX20_MOUSE

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Related Literatures of Post-Translational Modification

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