dbPTM

CD11B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CD11B_MOUSE
UniProt AC	P24788
Protein Name	Cyclin-dependent kinase 11B
Gene Name	Cdk11b
Organism	Mus musculus (Mouse).
Sequence Length	784
Subcellular Localization
Protein Description	Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. May act as a negative regulator of normal cell cycle progression..
Protein Sequence	MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKLREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREEYSDKGKVGHWSRSPLRPPRERFEMGDNRKPVKEEKVEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEEETGSNSEEASEQSAEEVSDEEMSEDEDRENENHILVVPESRFDRDSGDSEEGEEEVGEGTPQSSAPTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MGDEKDSWKVKTLD -CCCHHHHHHHCCHH	39.60	20469934
47	Phosphorylation	DRDSKRDSLEEGELR CCHHHHHHCHHCCCC	41.53	25521595
61	Phosphorylation	RDHRMEITIRNSPYR CCCEEEEEECCCCCC	10.69	30352176
65	Phosphorylation	MEITIRNSPYRREDS EEEEECCCCCCCCCC	17.29	26824392
67	Phosphorylation	ITIRNSPYRREDSME EEECCCCCCCCCCCC	23.32	25159016
72	Phosphorylation	SPYRREDSMEDRGEE CCCCCCCCCCCCCCC	21.22	25159016
113	Phosphorylation	KEKRRHRSHSAEGGK HHHHHHHHHCCCCCC	18.70	27087446
115	Phosphorylation	KRRHRSHSAEGGKHA HHHHHHHCCCCCCCH	29.30	27087446
232	Phosphorylation	KGKVGHWSRSPLRPP CCCCCCCCCCCCCCC	19.73	25266776
234	Phosphorylation	KVGHWSRSPLRPPRE CCCCCCCCCCCCCHH	23.83	26824392
253	Acetylation	GDNRKPVKEEKVEER CCCCCCCCHHHHHHH	69.55	23864654
264	Phosphorylation	VEERDLLSDLQDISD HHHHHHHHHHHHCCH	43.50	22802335
270	Phosphorylation	LSDLQDISDSERKTS HHHHHHCCHHHHCCC	43.29	27087446
272	Phosphorylation	DLQDISDSERKTSSA HHHHCCHHHHCCCCC	32.29	17203969
370	Phosphorylation	ESRFDRDSGDSEEGE HHHCCCCCCCCCCCC	45.45	26525534
373	Phosphorylation	FDRDSGDSEEGEEEV CCCCCCCCCCCCHHC	40.86	26525534
384	Phosphorylation	EEEVGEGTPQSSAPT CHHCCCCCCCCCCCC	17.53	25293948
387	Phosphorylation	VGEGTPQSSAPTEGD CCCCCCCCCCCCCCC	29.66	25293948
388	Phosphorylation	GEGTPQSSAPTEGDY CCCCCCCCCCCCCCC	32.78	25293948
391	Phosphorylation	TPQSSAPTEGDYVPD CCCCCCCCCCCCCCC	52.93	25293948
395	Phosphorylation	SAPTEGDYVPDSPAL CCCCCCCCCCCCCCC	25.41	25293948
399	Phosphorylation	EGDYVPDSPALSPIE CCCCCCCCCCCCHHH	13.15	25293948
403	Phosphorylation	VPDSPALSPIELKQE CCCCCCCCHHHHHHH	26.41	25293948
423	Phosphorylation	PALQGCRSVEEFQCL HHHCCCCCHHHHHHH	37.65	28066266
437	Phosphorylation	LNRIEEGTYGVVYRA HHCCCCCCCEEEEEE	22.00	29176673
471	Phosphorylation	KEGFPITSLREINTI HCCCCCCCHHHHHHH	26.58	-
477	Phosphorylation	TSLREINTILKAQHP CCHHHHHHHHHCCCC	33.09	-
553	Ubiquitination	WILHRDLKTSNLLLS EEECCCHHHHCCCHH	54.95	-
576	Phosphorylation	DFGLAREYGSPLKAY CCCHHHHHCCCCCCC	19.83	21082442
578	Phosphorylation	GLAREYGSPLKAYTP CHHHHHCCCCCCCCC	26.59	25521595
583	Phosphorylation	YGSPLKAYTPVVVTL HCCCCCCCCCEEEEE	15.25	21082442
584	Phosphorylation	GSPLKAYTPVVVTLW CCCCCCCCCEEEEEE	17.92	26824392
589	Phosphorylation	AYTPVVVTLWYRAPE CCCCEEEEEEECCHH	10.44	26745281
592	Phosphorylation	PVVVTLWYRAPELLL CEEEEEEECCHHHHH	10.46	23567750
630	Ubiquitination	QKPLFPGKSDIDQIN CCCCCCCCCCHHHHH	45.23	-
638	Ubiquitination	SDIDQINKIFKDLGT CCHHHHHHHHHHHCC	51.66	-
649	Ubiquitination	DLGTPSEKIWPGYND HHCCCHHHCCCCCCC	55.17	-
662	Ubiquitination	NDLPAVKKMTFSEYP CCCHHHHHCCCCCCC	36.25	-
740	Phosphorylation	QQRVKRGTSPRPPEG HHHHHCCCCCCCCCC	39.32	27087446
741	Phosphorylation	QRVKRGTSPRPPEGG HHHHCCCCCCCCCCC	23.03	27087446
751	Phosphorylation	PPEGGLGYSQLGDDD CCCCCCCCHHCCCCC	9.78	25521595
752	Phosphorylation	PEGGLGYSQLGDDDL CCCCCCCHHCCCCCH	19.68	27087446
762	Phosphorylation	GDDDLKETGFHLTTT CCCCHHHHCEEEEEC	43.49	25777480
767	Phosphorylation	KETGFHLTTTNQGAS HHHCEEEEECCCCCC	24.01	25777480
768	Phosphorylation	ETGFHLTTTNQGASA HHCEEEEECCCCCCC	30.06	25777480
769	Phosphorylation	TGFHLTTTNQGASAA HCEEEEECCCCCCCC	21.95	25777480
774	Phosphorylation	TTTNQGASAAGPGFS EECCCCCCCCCCCCC	26.02	25777480
781	Phosphorylation	SAAGPGFSLKF---- CCCCCCCCCCC----	36.24	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
471	S	Phosphorylation	Kinase	CDK7	Q03147	Uniprot
477	T	Phosphorylation	Kinase	CDK7	Q03147	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
115	S	Phosphorylation		-
Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CD11B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CD11B_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CD11B_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47; SER-264; SER-270;THR-740 AND SER-741, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-740 AND SER-741, ANDMASS SPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270, AND MASSSPECTROMETRY.	17203969 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270, AND MASSSPECTROMETRY.	15345747 [Abstract]

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