dbPTM

MAP4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MAP4_MOUSE
UniProt AC	P27546
Protein Name	Microtubule-associated protein 4
Gene Name	Map4
Organism	Mus musculus (Mouse).
Sequence Length	1125
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	Non-neuronal microtubule-associated protein. Promotes microtubule assembly..
Protein Sequence	MADLSLVDALTEPPPEIEGEIKRDFMAALEAEPYDDIVGETVEKTEFIPLLDGDEKTGNSESKKKPCLDTSQVEGIPSSKPTLLANGDHGMEGNNTAGSPTDFLEERVDYPDYQSSQNWPEDASFCFQPQQVLDTDQAEPFNEHRDDGLADLLFVSSGPTNASAFTERDNPSEDSYGMLPCDSFASTAVVSQEWSVGAPNSPCSESCVSPEVTIETLQPATELSKAAEVESVKEQLPAKALETMAEQTTDVVHSPSTDTTPGPDTEAALAKDIEEITKPDVILANVTQPSTESDMFLAQDMELLTGTEAAHANNIILPTEPDESSTKDVAPPMEEEIVPGNDTTSPKETETTLPIKMDLAPPEDVLLTKETELAPAKGMVSLSEIEEALAKNDESSAEIPVAQETVVSETEVVLATEVVLPSDPITTLTKDVTLPLEAERPLVTDMTPSLETEMTLGKETAPPTETNLGMAKDMSPLPESEVTLGKDVVILPETKVAEFNNVTPLSEEEVTSVKDMSPSAETEAPLAKNADLHSGTELIVDNSMAPASDLALPLETKVATVPIKDKGTVQTEEKPREDSQLASMQHKGQSTVPPCTASPEPVKAAEQMSTLPIDAPSPLENLEQKETPGSQPSEPCSGVSRQEEAKAAVGVTGNDITTPPNKEPPPSPEKKAKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTSGGLNKKPMSLASGSVPAAPHKRPAAATATARPSTLPARDVKPKPITEAKVAEKRTSPSKPSSAPALKPGPKTTPTVSKATSPSTLVSTGPSSRSPATTLPKRPTSIKTEGKPADVKRMTAKSASADLSRSKTTSASSVKRNTTPTGAAPPAGMTSTRVKPMSAPSRSSGALSVDKKPTSTKPSSSAPRVSRLATTVSAPDLKSVRSKVGSTENIKHQPGGGRAKVEKKTEAATTAGKPEPNAVTKAAGSIASAQKPPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEALPCPGPPAGEEPVIPEAAPDAGAPTSASGLSGHTTLSGGGDQREPQTLDSQIQETSI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADLSLVDA ------CCCCCHHHH	37.44	-
5	Phosphorylation	---MADLSLVDALTE ---CCCCCHHHHHCC	27.22	28507225
11	Phosphorylation	LSLVDALTEPPPEIE CCHHHHHCCCCCCCC	48.44	29514104
34	Phosphorylation	AALEAEPYDDIVGET HHHHCCCCCCCCCCE	20.11	29514104
45	Phosphorylation	VGETVEKTEFIPLLD CCCEECCCCEEECCC	23.71	20469934
60	Phosphorylation	GDEKTGNSESKKKPC CCCCCCCCCCCCCCC	44.59	-
60 (in isoform 4)	Phosphorylation	-	44.59	29899451
70	Phosphorylation	KKKPCLDTSQVEGIP CCCCCCCHHHCCCCC	14.22	23140645
71	Phosphorylation	KKPCLDTSQVEGIPS CCCCCCHHHCCCCCC	31.71	23140645
73 (in isoform 4)	Phosphorylation	-	7.93	22324799
74 (in isoform 4)	Phosphorylation	-	43.71	22324799
78	Phosphorylation	SQVEGIPSSKPTLLA HHCCCCCCCCCEEEE	49.42	23140645
79	Phosphorylation	QVEGIPSSKPTLLAN HCCCCCCCCCEEEEC	36.98	23649490
82	Phosphorylation	GIPSSKPTLLANGDH CCCCCCCEEEECCCC	37.83	23140645
93 (in isoform 4)	Phosphorylation	-	24.64	30372032
96	Phosphorylation	HGMEGNNTAGSPTDF CCCCCCCCCCCCCCH	36.07	26060331
99	Phosphorylation	EGNNTAGSPTDFLEE CCCCCCCCCCCHHHH	23.35	26824392
101	Phosphorylation	NNTAGSPTDFLEERV CCCCCCCCCHHHHHC	40.87	26160508
156	Phosphorylation	LADLLFVSSGPTNAS CCCEEEEECCCCCHH	23.42	22802335
157	Phosphorylation	ADLLFVSSGPTNASA CCEEEEECCCCCHHH	43.41	22802335
160	Phosphorylation	LFVSSGPTNASAFTE EEEECCCCCHHHCCC	47.12	22802335
163	Phosphorylation	SSGPTNASAFTERDN ECCCCCHHHCCCCCC	26.45	22802335
166	Phosphorylation	PTNASAFTERDNPSE CCCHHHCCCCCCCCC	29.81	22802335
172	Phosphorylation	FTERDNPSEDSYGML CCCCCCCCCCCCCEE	61.36	22802335
175	Phosphorylation	RDNPSEDSYGMLPCD CCCCCCCCCCEECCC	21.38	22802335
176	Phosphorylation	DNPSEDSYGMLPCDS CCCCCCCCCEECCCC	20.90	22817900
183	Phosphorylation	YGMLPCDSFASTAVV CCEECCCCCCCEEEE	29.45	22802335
186	Phosphorylation	LPCDSFASTAVVSQE ECCCCCCCEEEEECE	18.19	22802335
187	Phosphorylation	PCDSFASTAVVSQEW CCCCCCCEEEEECEE	21.75	22802335
191	Phosphorylation	FASTAVVSQEWSVGA CCCEEEEECEECCCC	18.78	22802335
195	Phosphorylation	AVVSQEWSVGAPNSP EEEECEECCCCCCCC	15.21	22802335
209	Phosphorylation	PCSESCVSPEVTIET CCCCCCCCCCCEEEE	21.48	23649490
212 (in isoform 4)	Phosphorylation	-	8.09	29899451
213	Phosphorylation	SCVSPEVTIETLQPA CCCCCCCEEEECCCH	16.07	22802335
214 (in isoform 4)	Phosphorylation	-	4.62	29899451
216	Phosphorylation	SPEVTIETLQPATEL CCCCEEEECCCHHHH	27.17	22802335
221	Phosphorylation	IETLQPATELSKAAE EEECCCHHHHHHHHH	44.11	22802335
224	Phosphorylation	LQPATELSKAAEVES CCCHHHHHHHHHHHH	17.64	22802335
231	Phosphorylation	SKAAEVESVKEQLPA HHHHHHHHHHHHCCH	43.60	26824392
243	Phosphorylation	LPAKALETMAEQTTD CCHHHHHHHHHHHCC	23.64	22942356
243 (in isoform 4)	Phosphorylation	-	23.64	29899451
248	Phosphorylation	LETMAEQTTDVVHSP HHHHHHHHCCCCCCC	19.23	22942356
249	Phosphorylation	ETMAEQTTDVVHSPS HHHHHHHCCCCCCCC	26.87	22942356
250 (in isoform 4)	Phosphorylation	-	43.77	29899451
254	Phosphorylation	QTTDVVHSPSTDTTP HHCCCCCCCCCCCCC	14.67	27087446
254 (in isoform 4)	Phosphorylation	-	14.67	29899451
256	Phosphorylation	TDVVHSPSTDTTPGP CCCCCCCCCCCCCCC	41.76	25521595
257	Phosphorylation	DVVHSPSTDTTPGPD CCCCCCCCCCCCCCC	40.52	27087446
259	Phosphorylation	VHSPSTDTTPGPDTE CCCCCCCCCCCCCHH	34.67	22942356
260	Phosphorylation	HSPSTDTTPGPDTEA CCCCCCCCCCCCHHH	29.11	27087446
265	Phosphorylation	DTTPGPDTEAALAKD CCCCCCCHHHHHHHC	30.56	25619855
277	Phosphorylation	AKDIEEITKPDVILA HHCHHHHCCCCEEEE	39.54	-
298 (in isoform 4)	Phosphorylation	-	7.64	22324799
301 (in isoform 4)	Phosphorylation	-	2.32	21183079
304 (in isoform 4)	Phosphorylation	-	2.37	22807455
333 (in isoform 4)	Phosphorylation	-	11.16	-
334 (in isoform 4)	Phosphorylation	-	59.25	-
343	Phosphorylation	EIVPGNDTTSPKETE CCCCCCCCCCCCCCC	32.92	25521595
344	Phosphorylation	IVPGNDTTSPKETET CCCCCCCCCCCCCCC	45.99	24925903
345	Phosphorylation	VPGNDTTSPKETETT CCCCCCCCCCCCCCC	35.75	25521595
349	Phosphorylation	DTTSPKETETTLPIK CCCCCCCCCCCCCCC	44.77	24925903
351	Phosphorylation	TSPKETETTLPIKMD CCCCCCCCCCCCCCC	40.84	25619855
352	Phosphorylation	SPKETETTLPIKMDL CCCCCCCCCCCCCCC	25.06	24925903
352 (in isoform 4)	Phosphorylation	-	25.06	29899451
354 (in isoform 4)	Phosphorylation	-	23.28	25521595
366 (in isoform 4)	Phosphorylation	-	8.54	20047950
381	Phosphorylation	APAKGMVSLSEIEEA CCCCCCEEHHHHHHH	19.79	26824392
383	Phosphorylation	AKGMVSLSEIEEALA CCCCEEHHHHHHHHH	29.08	28833060
383 (in isoform 4)	Phosphorylation	-	29.08	20047950
410	Phosphorylation	QETVVSETEVVLATE EEEECCCCEEEEEEE	26.94	-
429	Phosphorylation	SDPITTLTKDVTLPL CCCCCCCCCCEECCE	24.09	-
433	Phosphorylation	TTLTKDVTLPLEAER CCCCCCEECCEECCC	32.56	29899451
444	Phosphorylation	EAERPLVTDMTPSLE ECCCCCCCCCCCCCC	27.95	19060867
447	Phosphorylation	RPLVTDMTPSLETEM CCCCCCCCCCCCCEE	16.73	26824392
449	Phosphorylation	LVTDMTPSLETEMTL CCCCCCCCCCCEEEC	29.67	26824392
452	Phosphorylation	DMTPSLETEMTLGKE CCCCCCCCEEECCCC	36.03	21183079
455	Phosphorylation	PSLETEMTLGKETAP CCCCCEEECCCCCCC	26.57	23984901
474	Oxidation	NLGMAKDMSPLPESE CCCCCCCCCCCCHHH	4.36	17242355
475	Phosphorylation	LGMAKDMSPLPESEV CCCCCCCCCCCHHHE	33.16	24925903
475 (in isoform 3)	Phosphorylation	-	33.16	19144319
480	Phosphorylation	DMSPLPESEVTLGKD CCCCCCHHHEECCCC	35.11	25619855
483	Phosphorylation	PLPESEVTLGKDVVI CCCHHHEECCCCEEE	26.24	25619855
494	Phosphorylation	DVVILPETKVAEFNN CEEECCCCEEEEECC	28.95	25777480
503	Phosphorylation	VAEFNNVTPLSEEEV EEEECCCCCCCHHHC	22.19	26824392
506	Phosphorylation	FNNVTPLSEEEVTSV ECCCCCCCHHHCCCC	44.13	27087446
511	Phosphorylation	PLSEEEVTSVKDMSP CCCHHHCCCCCCCCC	30.96	27087446
512	Phosphorylation	LSEEEVTSVKDMSPS CCHHHCCCCCCCCCC	32.14	25521595
516	Oxidation	EVTSVKDMSPSAETE HCCCCCCCCCCCCCC	5.41	17242355
517	Phosphorylation	VTSVKDMSPSAETEA CCCCCCCCCCCCCCC	26.32	24925903
517 (in isoform 3)	Phosphorylation	-	26.32	19144319
519	Phosphorylation	SVKDMSPSAETEAPL CCCCCCCCCCCCCCC	31.28	25521595
522	Phosphorylation	DMSPSAETEAPLAKN CCCCCCCCCCCCCCC	36.84	24925903
579	Phosphorylation	EEKPREDSQLASMQH CCCCCCHHHHHHCCC	23.49	25338131
583	Phosphorylation	REDSQLASMQHKGQS CCHHHHHHCCCCCCC	27.80	22817900
590	Phosphorylation	SMQHKGQSTVPPCTA HCCCCCCCCCCCCCC	39.79	25619855
591	Phosphorylation	MQHKGQSTVPPCTAS CCCCCCCCCCCCCCC	29.19	25619855
595	S-nitrosocysteine	GQSTVPPCTASPEPV CCCCCCCCCCCCCCC	3.98	-
595	S-nitrosylation	GQSTVPPCTASPEPV CCCCCCCCCCCCCCC	3.98	21278135
596	Phosphorylation	QSTVPPCTASPEPVK CCCCCCCCCCCCCCC	35.62	26824392
598	Phosphorylation	TVPPCTASPEPVKAA CCCCCCCCCCCCCHH	16.19	27087446
609	Phosphorylation	VKAAEQMSTLPIDAP CCHHHHHCCCCCCCC	26.87	25619855
610	Phosphorylation	KAAEQMSTLPIDAPS CHHHHHCCCCCCCCC	31.07	25619855
617	Phosphorylation	TLPIDAPSPLENLEQ CCCCCCCCHHHCCHH	43.78	24925903
630	Phosphorylation	EQKETPGSQPSEPCS HHCCCCCCCCCCCCC	39.87	17525332
636	S-nitrosocysteine	GSQPSEPCSGVSRQE CCCCCCCCCCCCHHH	4.92	-
636	Glutathionylation	GSQPSEPCSGVSRQE CCCCCCCCCCCCHHH	4.92	24333276
636	S-nitrosylation	GSQPSEPCSGVSRQE CCCCCCCCCCCCHHH	4.92	21278135
652	Phosphorylation	AKAAVGVTGNDITTP HHHHHCCCCCCCCCC	25.08	25619855
657	Phosphorylation	GVTGNDITTPPNKEP CCCCCCCCCCCCCCC	35.79	25521595
658	Phosphorylation	VTGNDITTPPNKEPP CCCCCCCCCCCCCCC	36.76	25521595
667	Phosphorylation	PNKEPPPSPEKKAKP CCCCCCCCHHHCCCC	52.01	24925903
667 (in isoform 3)	Phosphorylation	-	52.01	19144319
683	Phosphorylation	ATTQPAKTSTSKAKT CCCCCCCCCCCCCCC	39.07	25338131
684	Phosphorylation	TTQPAKTSTSKAKTQ CCCCCCCCCCCCCCC	29.94	29895711
686	Phosphorylation	QPAKTSTSKAKTQPT CCCCCCCCCCCCCCC	30.31	25338131
694	Phosphorylation	KAKTQPTSLPKQPAP CCCCCCCCCCCCCCC	49.73	-
713	Phosphorylation	GLNKKPMSLASGSVP CCCCCCCCHHCCCCC	29.34	21183079
716	Phosphorylation	KKPMSLASGSVPAAP CCCCCHHCCCCCCCC	36.57	21183079
718	Phosphorylation	PMSLASGSVPAAPHK CCCHHCCCCCCCCCC	23.56	28066266
733	Phosphorylation	RPAAATATARPSTLP CCCCCCCCCCCCCCC	20.88	25890499
737	Phosphorylation	ATATARPSTLPARDV CCCCCCCCCCCCCCC	36.70	28464351
759	Phosphorylation	AKVAEKRTSPSKPSS HHHHCCCCCCCCCCC	56.93	18388127
760	Phosphorylation	KVAEKRTSPSKPSSA HHHCCCCCCCCCCCC	31.07	18388127
761 (in isoform 4)	Phosphorylation	-	45.84	26824392
762	Phosphorylation	AEKRTSPSKPSSAPA HCCCCCCCCCCCCCC	57.89	18388127
762 (in isoform 4)	Phosphorylation	-	57.89	29514104
765	Phosphorylation	RTSPSKPSSAPALKP CCCCCCCCCCCCCCC	42.75	24925903
766	Phosphorylation	TSPSKPSSAPALKPG CCCCCCCCCCCCCCC	46.96	24925903
777	Phosphorylation	LKPGPKTTPTVSKAT CCCCCCCCCCCCCCC	24.08	18779572
779	Phosphorylation	PGPKTTPTVSKATSP CCCCCCCCCCCCCCC	35.01	26160508
781	Phosphorylation	PKTTPTVSKATSPST CCCCCCCCCCCCCCE	21.03	26160508
784	Phosphorylation	TPTVSKATSPSTLVS CCCCCCCCCCCEEEE	44.93	24925903
785	Phosphorylation	PTVSKATSPSTLVST CCCCCCCCCCEEEEC	23.01	24925903
787	Phosphorylation	VSKATSPSTLVSTGP CCCCCCCCEEEECCC	33.85	24925903
787 (in isoform 4)	Phosphorylation	-	33.85	29514104
788	Phosphorylation	SKATSPSTLVSTGPS CCCCCCCEEEECCCC	34.27	25521595
788 (in isoform 4)	Phosphorylation	-	34.27	29514104
791	Phosphorylation	TSPSTLVSTGPSSRS CCCCEEEECCCCCCC	30.66	25619855
792	Phosphorylation	SPSTLVSTGPSSRSP CCCEEEECCCCCCCC	45.70	25619855
795	Phosphorylation	TLVSTGPSSRSPATT EEEECCCCCCCCCCC	39.46	24925903
796	Phosphorylation	LVSTGPSSRSPATTL EEECCCCCCCCCCCC	39.65	24925903
798	Phosphorylation	STGPSSRSPATTLPK ECCCCCCCCCCCCCC	22.34	25521595
801	Phosphorylation	PSSRSPATTLPKRPT CCCCCCCCCCCCCCC	32.05	25619855
802	Phosphorylation	SSRSPATTLPKRPTS CCCCCCCCCCCCCCC	43.07	25619855
808	Phosphorylation	TTLPKRPTSIKTEGK CCCCCCCCCCCCCCC	47.30	25777480
809	Phosphorylation	TLPKRPTSIKTEGKP CCCCCCCCCCCCCCH	25.44	25777480
811	Acetylation	PKRPTSIKTEGKPAD CCCCCCCCCCCCHHH	40.05	22826441
823	Phosphorylation	PADVKRMTAKSASAD HHHHHHHHHHHHCHH	34.66	25619855
826	Phosphorylation	VKRMTAKSASADLSR HHHHHHHHHCHHHHC	25.62	25619855
828	Phosphorylation	RMTAKSASADLSRSK HHHHHHHCHHHHCCC	29.43	26824392
840	Phosphorylation	RSKTTSASSVKRNTT CCCCCCCHHHCCCCC	35.12	18779572
841	Phosphorylation	SKTTSASSVKRNTTP CCCCCCHHHCCCCCC	31.23	25266776
846	Phosphorylation	ASSVKRNTTPTGAAP CHHHCCCCCCCCCCC	37.88	25521595
847	Phosphorylation	SSVKRNTTPTGAAPP HHHCCCCCCCCCCCC	23.54	27087446
849	Phosphorylation	VKRNTTPTGAAPPAG HCCCCCCCCCCCCCC	37.04	27742792
858	Phosphorylation	AAPPAGMTSTRVKPM CCCCCCCCCCCEECC	26.48	25619855
859	Phosphorylation	APPAGMTSTRVKPMS CCCCCCCCCCEECCC	12.81	25619855
860	Phosphorylation	PPAGMTSTRVKPMSA CCCCCCCCCEECCCC	30.25	25619855
866	Phosphorylation	STRVKPMSAPSRSSG CCCEECCCCCCCCCC	45.62	26060331
869	Phosphorylation	VKPMSAPSRSSGALS EECCCCCCCCCCCCC	44.50	29899451
871	Phosphorylation	PMSAPSRSSGALSVD CCCCCCCCCCCCCCC	37.14	25521595
872	Phosphorylation	MSAPSRSSGALSVDK CCCCCCCCCCCCCCC	27.29	23737553
876	Phosphorylation	SRSSGALSVDKKPTS CCCCCCCCCCCCCCC	27.95	23737553
887	O-linked_Glycosylation	KPTSTKPSSSAPRVS CCCCCCCCCCCCCHH	38.18	22517741
887	Phosphorylation	KPTSTKPSSSAPRVS CCCCCCCCCCCCCHH	38.18	29899451
888	Phosphorylation	PTSTKPSSSAPRVSR CCCCCCCCCCCCHHH	38.76	23684622
889	Phosphorylation	TSTKPSSSAPRVSRL CCCCCCCCCCCHHHE	46.78	19854140
894	Phosphorylation	SSSAPRVSRLATTVS CCCCCCHHHEEEECC	23.90	22817900
898	Phosphorylation	PRVSRLATTVSAPDL CCHHHEEEECCCCCH	32.11	24925903
899	Phosphorylation	RVSRLATTVSAPDLK CHHHEEEECCCCCHH	13.57	24925903
901	Phosphorylation	SRLATTVSAPDLKSV HHEEEECCCCCHHHH	31.80	24925903
906	Ubiquitination	TVSAPDLKSVRSKVG ECCCCCHHHHHHHCC	55.04	-
907	Phosphorylation	VSAPDLKSVRSKVGS CCCCCHHHHHHHCCC	30.02	29176673
910	Phosphorylation	PDLKSVRSKVGSTEN CCHHHHHHHCCCCCC	29.54	25266776
914	Phosphorylation	SVRSKVGSTENIKHQ HHHHHCCCCCCCCCC	35.22	25521595
914 (in isoform 3)	Phosphorylation	-	35.22	26824392
915	Phosphorylation	VRSKVGSTENIKHQP HHHHCCCCCCCCCCC	27.42	25521595
915 (in isoform 3)	Phosphorylation	-	27.42	29514104
931 (in isoform 3)	Phosphorylation	-	68.90	-
935 (in isoform 3)	Phosphorylation	-	18.49	29514104
936 (in isoform 3)	Phosphorylation	-	10.15	29514104
937	Phosphorylation	EKKTEAATTAGKPEP ECCCHHHHCCCCCCC	24.99	-
938	Phosphorylation	KKTEAATTAGKPEPN CCCHHHHCCCCCCCC	28.78	-
941 (in isoform 3)	Phosphorylation	-	43.68	29514104
948	Phosphorylation	KPEPNAVTKAAGSIA CCCCCHHHHHHHHHH	16.74	-
953	Phosphorylation	AVTKAAGSIASAQKP HHHHHHHHHHHCCCC	15.39	26824392
956	Phosphorylation	KAAGSIASAQKPPAG HHHHHHHHCCCCCCC	29.57	28066266
973	Phosphorylation	QIVSKKVSYSHIQSK EEEEEEECHHHHHHH	29.78	26824392
974	Phosphorylation	IVSKKVSYSHIQSKC EEEEEECHHHHHHHC	13.78	23984901
975	Phosphorylation	VSKKVSYSHIQSKCG EEEEECHHHHHHHCC	13.45	29472430
979	Phosphorylation	VSYSHIQSKCGSKDN ECHHHHHHHCCCCCC	29.34	29514104
983	Phosphorylation	HIQSKCGSKDNIKHV HHHHHCCCCCCCCCC	46.43	-
988	Acetylation	CGSKDNIKHVPGGGN CCCCCCCCCCCCCCC	44.82	22826441
1001	Acetylation	GNVQIQNKKVDISKV CCEEECCCEEEHHHC	37.49	22902405
1006	Phosphorylation	QNKKVDISKVSSKCG CCCEEEHHHCHHHCC	23.65	23737553
1007	Acetylation	NKKVDISKVSSKCGS CCEEEHHHCHHHCCC	46.61	6569299
1008 (in isoform 3)	Phosphorylation	-	6.62	19144319
1009	Phosphorylation	KVDISKVSSKCGSKA EEEHHHCHHHCCCCC	28.02	29176673
1010	Phosphorylation	VDISKVSSKCGSKAN EEHHHCHHHCCCCCC	34.65	22802335
1014	Phosphorylation	KVSSKCGSKANIKHK HCHHHCCCCCCCCCC	37.76	-
1019	Acetylation	CGSKANIKHKPGGGD CCCCCCCCCCCCCCC	45.44	6568609
1021	Acetylation	SKANIKHKPGGGDVK CCCCCCCCCCCCCCC	40.11	6569575
1031	Phosphorylation	GGDVKIESQKLNFKE CCCCCEEEEECCHHH	35.77	29176673
1033	Acetylation	DVKIESQKLNFKEKA CCCEEEEECCHHHHH	55.46	22826441
1046	Phosphorylation	KAQAKVGSLDNVGHL HHHHHCCCCCCCCCC	35.22	24925903
1115	Phosphorylation	GDQREPQTLDSQIQE CCCCCCCCHHHHHHH	43.16	28066266
1118	Phosphorylation	REPQTLDSQIQETSI CCCCCHHHHHHHCCC	32.09	-
1123	Phosphorylation	LDSQIQETSI----- HHHHHHHCCC-----	18.49	28066266
1124	Phosphorylation	DSQIQETSI------ HHHHHHCCC------	26.08	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
914	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
914	S	Phosphorylation	Kinase	AMPKA1	Q5EG47	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
333	S	Phosphorylation	-
Isoform 4 is phosphorylated on Ser-333 and Ser-334 (By similarity).
334	S	Phosphorylation	-
Isoform 4 is phosphorylated on Ser-333 and Ser-334 (By similarity).
760	S	Phosphorylation	21183079
Phosphorylation on Ser-760 negatively regulates MAP4 activity to promote microtubule assembly.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MAP4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MAP4_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MAP4_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475 AND SER-667, ANDMASS SPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475 AND SER-1046, ANDMASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1046, AND MASSSPECTROMETRY.	19367708 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-630, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254; THR-503; SER-506;SER-517 AND SER-785, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517; SER-598; THR-784AND THR-847, AND MASS SPECTROMETRY.	17114649 [Abstract]
"Proteomic analysis of in vivo phosphorylated synaptic proteins."; Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I.,Blackstock W.P., Choudhary J.S., Grant S.G.; J. Biol. Chem. 280:5972-5982(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667, AND MASSSPECTROMETRY.	15572359 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254; THR-260; THR-511;SER-517; SER-519 AND SER-617, AND MASS SPECTROMETRY.	15345747 [Abstract]

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