dbPTM

MPP10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MPP10_MOUSE
UniProt AC	Q810V0
Protein Name	U3 small nucleolar ribonucleoprotein protein MPP10
Gene Name	Mphosph10
Organism	Mus musculus (Mouse).
Sequence Length	681
Subcellular Localization	Nucleus, nucleolus . Chromosome . Fibrillar region of the nucleolus. After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase. In telophase localized to small cellular prenucleolar bodies
Protein Description	Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity)..
Protein Sequence	MAPRVFRRQTLERCLREIRKATNRPECFLTIQNGLASNFTSLTKVLYDFNKVLENGRISGSPLQKLEINSFDDEQIWQQLELQNEPVLQYFQNAVSETVEDEDISLLPECEDEECEEDASEVEADNQENLETDLDEEQLSDEGGDVPKGRDRAKSSRKSDPRKSPVFSDEDSDLDFDIGKLEQQTKMQIKPPGKPREKSVVDDKFFKLSEMESFLEKVEKEEEKRPDGEEEDEEDIDLFEDIDSDESEGGLFGRQKIKSNKSSRNLKYKDFFDPVESDEDITGVDEELGPDEEKEEEEGFAEEADESISDTDEDNDLEEDENSDQHKGSLKRVTFALPDDEAEDTSPLAVKQESDEVKSSFEKRQEKMNEKIASLEKELLDKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLHLEDIIKQRIRDQAWDDVERKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYLKLNQQKTEEEDNPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDLKTAAEKTATDKKRERRKKKYQKRLKIKEKEKRKKLLEKNNPDQSKSSRAAASEKLKQLTKTGKVSLLKDERKDKPLKSSQAFFSKLQDQVKMQINDAKQPEKIKKKKQDISVHKLKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	ENGRISGSPLQKLEI HHCCCCCCCCCEEEE	18.69	27841257
120	Phosphorylation	EECEEDASEVEADNQ HHHCCCHHHCHHHHH	55.27	-
140	Phosphorylation	DLDEEQLSDEGGDVP CCCHHHHHCCCCCCC	33.05	-
159	Phosphorylation	RAKSSRKSDPRKSPV HHHHCCCCCCCCCCC	52.30	23608596
164	Phosphorylation	RKSDPRKSPVFSDED CCCCCCCCCCCCCCC	27.81	25521595
168	Phosphorylation	PRKSPVFSDEDSDLD CCCCCCCCCCCCCCC	40.08	27087446
172	Phosphorylation	PVFSDEDSDLDFDIG CCCCCCCCCCCCCHH	37.72	25521595
185	Phosphorylation	IGKLEQQTKMQIKPP HHHHHHHHCCCCCCC	28.33	25619855
209	Phosphorylation	DDKFFKLSEMESFLE CHHHHHHHHHHHHHH	35.17	26824392
213	Phosphorylation	FKLSEMESFLEKVEK HHHHHHHHHHHHHHH	33.55	28066266
244	Phosphorylation	DLFEDIDSDESEGGL CCHHCCCCCCCCCCC	43.54	27087446
247	Phosphorylation	EDIDSDESEGGLFGR HCCCCCCCCCCCCCH	46.67	27087446
268	Phosphorylation	KSSRNLKYKDFFDPV CCCCCCCHHHHCCCC	20.96	23984901
277	Phosphorylation	DFFDPVESDEDITGV HHCCCCCCCCCCCCC	46.67	27818261
282	Phosphorylation	VESDEDITGVDEELG CCCCCCCCCCCCCCC	43.40	27180971
334	Phosphorylation	KGSLKRVTFALPDDE CCCCEEEEEECCCCC	13.76	25619855
345	Phosphorylation	PDDEAEDTSPLAVKQ CCCCCCCCCCCEEHH	24.61	27087446
346	Phosphorylation	DDEAEDTSPLAVKQE CCCCCCCCCCEEHHC	30.18	25521595
354	Phosphorylation	PLAVKQESDEVKSSF CCEEHHCCHHHHHHH	36.26	26643407
374	Phosphorylation	KMNEKIASLEKELLD HHHHHHHHHHHHHHH	40.30	23737553
571	Phosphorylation	LKTAAEKTATDKKRE HHHHHHHHHHHHHHH	26.71	28576409
609	Acetylation	KNNPDQSKSSRAAAS HCCCCCCHHHHHHHH	46.98	-
649	Acetylation	SSQAFFSKLQDQVKM HHHHHHHHHHHHHHH	45.04	23806337
662	Acetylation	KMQINDAKQPEKIKK HHHHCCCCCHHHHHH	70.06	19846475
666	Acetylation	NDAKQPEKIKKKKQD CCCCCHHHHHHHCCC	67.52	19846483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MPP10_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MPP10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MPP10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MPP10_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MPP10_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND SER-247, ANDMASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, AND MASSSPECTROMETRY.	17242355 [Abstract]