NSD3_MOUSE - dbPTM
NSD3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NSD3_MOUSE
UniProt AC Q6P2L6
Protein Name Histone-lysine N-methyltransferase NSD3
Gene Name Nsd3
Organism Mus musculus (Mouse).
Sequence Length 1439
Subcellular Localization Nucleus. Chromosome.
Protein Description Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression (By similarity)..
Protein Sequence MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNHSDIVEDGGPTPFEATLQQGFQYPPTTEDLPPLTNGYPPSISLYETQTKYPPYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNRHESSRSEERRSHKIPKLEPEGQNRPNERVDTAPEKPREEPVLKEAIPVQPILSSVPTTETSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHSKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHEQYEELLAEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERVEQYTFIYIDKQPEEASSQAKKNVTSKTEVKKPRRPRSVLNSQPEQTNAGEVASSQSSTDLRRQSQRRHTSLEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISSPSQRSEKPAQSASSPEATSGSAGPVEKKQQRRSIRTRSESEKSAEVVPKKKIKKEQVETAPQASLKTGLQKGASEISDSCKPLKKRSRASTDVETASCTYRDTSDSDSRGLSDGQVGFGKQVDSPSATADADASDAQSVDSSLSRRGVGTSKKDTVCQVCEKAGDCLVACEGECCRHFHVECLGLTAVPEGHFTCEECETGQHPCFSCKVSGKDVKRCSVSVCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKGRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRQVLWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKHFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEMERTSRKPPPYKHIKANKVIGKVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSACTSAVDEKTKNAKLKKRRKVKAEAKPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPHGKWECPWHRCDECGSVAVSFCEFCPHSFCKAHGKGALVPSALEGRLCCSSHDPASPVSPEYWSKIRCKWESQDSGEEVKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
107PhosphorylationFGAVRNFSPTDYYHS
CCCCCCCCCCCCCCC		30.3625266776
109PhosphorylationAVRNFSPTDYYHSEI
CCCCCCCCCCCCCCC		35.1226643407
111PhosphorylationRNFSPTDYYHSEIPN
CCCCCCCCCCCCCCC		12.9329472430
129 (in isoform 4)Phosphorylation-61.3522802335
129 (in isoform 2)Phosphorylation-61.3522802335
148PhosphorylationQTVIPKKTGSPEIKL
CCCCCCCCCCCCEEE		49.3627681418
150PhosphorylationVIPKKTGSPEIKLKI
CCCCCCCCCCEEEEE		25.2926824392
159UbiquitinationEIKLKITKTIQNGRE
CEEEEEEEEEHHCHH		47.29-
205PhosphorylationKKSNRHESSRSEERR
HHHHCCCCHHHHHHH		25.56-
424PhosphorylationKKPRRPRSVLNSQPE
CCCCCCCHHHHCCCC		33.3722345495
428PhosphorylationRPRSVLNSQPEQTNA
CCCHHHHCCCCCCCH		42.8422345495
433PhosphorylationLNSQPEQTNAGEVAS
HHCCCCCCCHHHHCC		25.9322345495
440PhosphorylationTNAGEVASSQSSTDL
CCHHHHCCCCCHHHH		33.8022345495
441PhosphorylationNAGEVASSQSSTDLR
CHHHHCCCCCHHHHH		25.0922345495
443PhosphorylationGEVASSQSSTDLRRQ
HHHCCCCCHHHHHHH		36.8322345495
444PhosphorylationEVASSQSSTDLRRQS
HHCCCCCHHHHHHHH		20.5022345495
445PhosphorylationVASSQSSTDLRRQSQ
HCCCCCHHHHHHHHH		44.2822345495
456PhosphorylationRQSQRRHTSLEEEEP
HHHHHHCCCCCCCCC		32.9427566939
457PhosphorylationQSQRRHTSLEEEEPP
HHHHHCCCCCCCCCC		27.8825521595
471AcetylationPPVKIAWKTAAARKS
CCCEEEEEHHHHHHC		21.1823806337
478PhosphorylationKTAAARKSLPASITM
EHHHHHHCCCCEEEE		33.7526745281
482PhosphorylationARKSLPASITMHKGS
HHHCCCCEEEEECCC		19.3626745281
489PhosphorylationSITMHKGSLDLQKCN
EEEEECCCCCHHHCC		24.42-
498PhosphorylationDLQKCNMSPVVKIEQ
CHHHCCCCCCEEEEE		10.6825266776
532AcetylationSTKGIGNKTEISVRG
ECCCCCCCEEEEECC		42.1823806337
546PhosphorylationGQDRLIISSPSQRSE
CCCEEEEECCCCCCC		29.2427566939
547PhosphorylationQDRLIISSPSQRSEK
CCEEEEECCCCCCCC		20.4026824392
549PhosphorylationRLIISSPSQRSEKPA
EEEEECCCCCCCCCC		39.9322942356
552PhosphorylationISSPSQRSEKPAQSA
EECCCCCCCCCCCCC		42.1927087446
558PhosphorylationRSEKPAQSASSPEAT
CCCCCCCCCCCCCCC		32.0227742792
560PhosphorylationEKPAQSASSPEATSG
CCCCCCCCCCCCCCC		52.2327087446
561PhosphorylationKPAQSASSPEATSGS
CCCCCCCCCCCCCCC		26.8627087446
565PhosphorylationSASSPEATSGSAGPV
CCCCCCCCCCCCCCH		31.7723375375
566PhosphorylationASSPEATSGSAGPVE
CCCCCCCCCCCCCHH		37.4925619855
568PhosphorylationSPEATSGSAGPVEKK
CCCCCCCCCCCHHHH		29.8025619855
580PhosphorylationEKKQQRRSIRTRSES
HHHHHHHHHHCCCHH		20.72-
583PhosphorylationQQRRSIRTRSESEKS
HHHHHHHCCCHHHHH		36.5630482847
585PhosphorylationRRSIRTRSESEKSAE
HHHHHCCCHHHHHCC		44.8825266776
587PhosphorylationSIRTRSESEKSAEVV
HHHCCCHHHHHCCCC		52.1225266776
590PhosphorylationTRSESEKSAEVVPKK
CCCHHHHHCCCCCHH		26.1325521595
634PhosphorylationCKPLKKRSRASTDVE
CCCCHHHCCCCCCCE		40.8725619855
637PhosphorylationLKKRSRASTDVETAS
CHHHCCCCCCCEECC		24.8325619855
638PhosphorylationKKRSRASTDVETASC
HHHCCCCCCCEECCC		42.9825619855
642PhosphorylationRASTDVETASCTYRD
CCCCCCEECCCEEEC		24.5825619855
644PhosphorylationSTDVETASCTYRDTS
CCCCEECCCEEECCC		17.8925619855
646PhosphorylationDVETASCTYRDTSDS
CCEECCCEEECCCCC		21.0625619855
647PhosphorylationVETASCTYRDTSDSD
CEECCCEEECCCCCC		15.7225619855
650PhosphorylationASCTYRDTSDSDSRG
CCCEEECCCCCCCCC		25.9930635358
651PhosphorylationSCTYRDTSDSDSRGL
CCEEECCCCCCCCCC		39.1330635358
653PhosphorylationTYRDTSDSDSRGLSD
EEECCCCCCCCCCCC		36.9330635358
655PhosphorylationRDTSDSDSRGLSDGQ
ECCCCCCCCCCCCCC		32.0030635358
659PhosphorylationDSDSRGLSDGQVGFG
CCCCCCCCCCCCCCC		42.3828066266
671PhosphorylationGFGKQVDSPSATADA
CCCCCCCCCCCCCCC		23.1530635358
673PhosphorylationGKQVDSPSATADADA
CCCCCCCCCCCCCCC		42.0530635358
675PhosphorylationQVDSPSATADADASD
CCCCCCCCCCCCCHH		29.4330635358
681PhosphorylationATADADASDAQSVDS
CCCCCCCHHHHHHHH		33.7430635358
685PhosphorylationADASDAQSVDSSLSR
CCCHHHHHHHHHHHH		29.6130635358
688PhosphorylationSDAQSVDSSLSRRGV
HHHHHHHHHHHHCCC		30.9025338131
790AcetylationPTAIFESKGFRCPQH
CCHHHHCCCCCCCHH		55.6723806337
911PhosphorylationLPMIPSSSASKKRCE
CCCCCCCHHHHCHHC		40.6825338131
913PhosphorylationMIPSSSASKKRCEKG
CCCCCHHHHCHHCCC		40.4325338131
915AcetylationPSSSASKKRCEKGGR
CCCHHHHCHHCCCCE		60.842388423
1042AcetylationSINKTFKKALEEAAK
HHHHHHHHHHHHHHH		54.7530988519
1049AcetylationKALEEAAKRFQELKA
HHHHHHHHHHHHHHH		61.8730988525
1430PhosphorylationKIRCKWESQDSGEEV
HCCCEEECCCCCCCC		37.8728066266
1433PhosphorylationCKWESQDSGEEVKE-
CEEECCCCCCCCCC-		40.2327087446
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NSD3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NSD3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NSD3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NSD3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NSD3_MOUSE

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Related Literatures of Post-Translational Modification

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