IKZF3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IKZF3_MOUSE
• UniProt AC: O08900
• Protein Name: Zinc finger protein Aiolos
• Gene Name: Ikzf3
• Organism: Mus musculus (Mouse).
• Sequence Length: 507
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Binds to GGGAA. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner..
• Protein Sequence: MEDIQPTVELKSTEEQPLPTESPDALNDYSLPKPHEIENVDSREAPANEDEDAGEDSMKVKDEYSDRDENIMKPEPMGDAEESEMPYSYAREYSDYESIKLERHVPYDNSRPTGGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRAFLQNPDLGDAASVEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDANYNPGYMYEKENEMMQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSVYPIALTRADMPNGAPQEMEKKRILLPEKILPSERGLSPNNSAQDSTDTDSNHEDRQHLYQQSHVVLPQARNGMPLLKEVPRSFELLKPPPICLRDSIKVINKEGEVMDVFRCDHCHVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRAMLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEDIQPTVELKSTE -CCCCCCCEECCCCC	15.38	22817900
20	Phosphorylation	TEEQPLPTESPDALN CCCCCCCCCCCCCHH	57.70	24704852
22	Phosphorylation	EQPLPTESPDALNDY CCCCCCCCCCCHHCC	30.47	24704852
29	Phosphorylation	SPDALNDYSLPKPHE CCCCHHCCCCCCCCC	15.84	29472430
30	Phosphorylation	PDALNDYSLPKPHEI CCCHHCCCCCCCCCC	40.85	26026062
42	Phosphorylation	HEIENVDSREAPANE CCCCCCCCCCCCCCC	27.95	24704852
65	Phosphorylation	MKVKDEYSDRDENIM CCCCCCCCCCCCCCC	24.91	21183079
94	Phosphorylation	YSYAREYSDYESIKL CCHHHHCCCCCCEEE	29.03	27600695
96	Phosphorylation	YAREYSDYESIKLER HHHHCCCCCCEEEEE	12.97	26026062
98	Phosphorylation	REYSDYESIKLERHV HHCCCCCCEEEEECC	20.85	27600695
138	Phosphorylation	VLMVHKRSHTGERPF EEEEECCCCCCCCCC	30.15	25266776
140	Phosphorylation	MVHKRSHTGERPFQC EEECCCCCCCCCCCC	41.82	27600695
168	Phosphorylation	LRHIKLHTGEKPFKC EEEEEEECCCCCEEE	58.43	28066266
214	Phosphorylation	GRSYKQRSSLEEHKE CCCHHCCCCHHHHHH	36.46	-
215	Phosphorylation	RSYKQRSSLEEHKER CCHHCCCCHHHHHHH	41.82	-
237	Phosphorylation	PDLGDAASVEARHIK CCCCCCHHHHHHHHH	23.39	25266776
244	Ubiquitination	SVEARHIKAEMGSER HHHHHHHHHHHCCHH	31.97	-
260	Phosphorylation	LVLDRLASNVAKRKS HHHHHHHHHHHHHHC	36.11	24843327
267	Phosphorylation	SNVAKRKSSMPQKFI HHHHHHHCCCCHHHH	35.58	25266776
268	Phosphorylation	NVAKRKSSMPQKFIG HHHHHHCCCCHHHHC	37.20	27600695
325	Phosphorylation	ALRPLVQTPPAPTSE HHHHHHCCCCCCCHH	24.62	21189417
372	Phosphorylation	LPEKILPSERGLSPN CCHHCCCCCCCCCCC	36.16	27600695
377	Phosphorylation	LPSERGLSPNNSAQD CCCCCCCCCCCCCCC	28.53	28833060
381	Phosphorylation	RGLSPNNSAQDSTDT CCCCCCCCCCCCCCC	33.67	28285833
385	Phosphorylation	PNNSAQDSTDTDSNH CCCCCCCCCCCCCCH	18.99	22817900
386	Phosphorylation	NNSAQDSTDTDSNHE CCCCCCCCCCCCCHH	51.73	21183079
388	Phosphorylation	SAQDSTDTDSNHEDR CCCCCCCCCCCHHHH	41.22	21082442
390	Phosphorylation	QDSTDTDSNHEDRQH CCCCCCCCCHHHHHH	42.02	28833060
436	Phosphorylation	PPICLRDSIKVINKE CCEEECCCEEEECCC	20.20	27600695

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IKZF3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IKZF3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IKZF3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.