UniProt ID | TF3C2_MOUSE | |
---|---|---|
UniProt AC | Q8BL74 | |
Protein Name | General transcription factor 3C polypeptide 2 | |
Gene Name | Gtf3c2 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 907 | |
Subcellular Localization | Nucleus. | |
Protein Description | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 (By similarity).. | |
Protein Sequence | MDTCGVGYVALGEADPVGSMIVVDSPGQEELSQLDVKASETSGVEASIEMSLPPPLPGFEDSSDRRLPPDQESLTRLEQQDLSSEMSKVSNTRASKPSGRRGGRTARGAKRPQQRKPPSTPLVPGLLDQSNPLSTPMPKKRSQKSKGDLLLLKLSKGLDQPESPHPKRPPEDFETPSGERPRRRAAQVALLYLQELAEELSTALPAPPLSGPKSPKVSSPTKPKKTRQASSQGEEDGSARDEDFVLQVEGEDEEESEAPSENSSDPEPVAPRSTPRGPAAGKQKPHCRGMAPNGLPNYIMAPVWKCLHLTKDLREQHHSFWEFAEWIPVAWKWQLLSELEAAPYLPQEEKSPLFSVQREGIPEDGTIYRINRFSSITAHPERWDVSFFTGGPLWALDWCPVPEGSAASQYVALFSSPDMNETHPLSQLHSGPGLLQLWGLGTLQQESCPGNRAHFVYGIACDSGCIWDLKFCPSGAWEHPETLRKAPLLPRLGLLALACSDGKVLLFSLPHPEALLAQQPPDAMKPAIYKVQCLATLQVGSVQASDPSECGQCLSLAWMPTRPHHHLAAGYYNGMVVFWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTIQWCKANSHFLVSAGSDRKIKFWDLRRPYEPINCIKRFLSTELSWLLPYNGVTVAQDNCYASYGLCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTVAAGDISGELIAAILPDMASNPINVKKPAERRFPIYKADLIPYQDSPEDQDYSSTSSETPNPPKARTYTETINHHYLLFQDTDLSSFHNLLRREPMLRMQEGEGHSQLCLDRLQLEAIHKVRFSPNLDSYGWLVSGGQSGLVRIHFVRGLTSPLAHRVQLESRANFNAMFQPSFPTEGPGFSPSSHCLLPNP | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
25 | Phosphorylation | GSMIVVDSPGQEELS CCEEEECCCCCHHHH | 21.22 | 30352176 | |
62 | Phosphorylation | PLPGFEDSSDRRLPP CCCCCCCCCCCCCCC | 27.26 | - | |
83 | Phosphorylation | RLEQQDLSSEMSKVS HHHHHHHHHHHHHHH | 32.32 | 27841257 | |
84 | Phosphorylation | LEQQDLSSEMSKVSN HHHHHHHHHHHHHHC | 44.61 | 27841257 | |
90 | Phosphorylation | SSEMSKVSNTRASKP HHHHHHHHCCCCCCC | 35.90 | 30387612 | |
96 | Methylation | VSNTRASKPSGRRGG HHCCCCCCCCCCCCC | 42.07 | - | |
130 | Phosphorylation | VPGLLDQSNPLSTPM CCCCCCCCCCCCCCC | 39.83 | 26643407 | |
134 | Phosphorylation | LDQSNPLSTPMPKKR CCCCCCCCCCCCCCC | 31.55 | 26643407 | |
135 | Phosphorylation | DQSNPLSTPMPKKRS CCCCCCCCCCCCCCC | 31.15 | 26643407 | |
153 | Acetylation | KGDLLLLKLSKGLDQ CCCHHHHHHHCCCCC | 51.16 | 19849111 | |
163 | Phosphorylation | KGLDQPESPHPKRPP CCCCCCCCCCCCCCC | 34.88 | 25521595 | |
192 | Phosphorylation | AAQVALLYLQELAEE HHHHHHHHHHHHHHH | 13.74 | 23984901 | |
201 | Phosphorylation | QELAEELSTALPAPP HHHHHHHHHCCCCCC | 18.21 | 23984901 | |
202 | Phosphorylation | ELAEELSTALPAPPL HHHHHHHHCCCCCCC | 44.85 | 23984901 | |
210 | Phosphorylation | ALPAPPLSGPKSPKV CCCCCCCCCCCCCCC | 59.84 | 26239621 | |
214 | Phosphorylation | PPLSGPKSPKVSSPT CCCCCCCCCCCCCCC | 32.84 | 26239621 | |
216 | Acetylation | LSGPKSPKVSSPTKP CCCCCCCCCCCCCCC | 62.94 | 19856619 | |
218 | Phosphorylation | GPKSPKVSSPTKPKK CCCCCCCCCCCCCCC | 36.40 | 26745281 | |
219 | Phosphorylation | PKSPKVSSPTKPKKT CCCCCCCCCCCCCCC | 39.31 | 26824392 | |
221 | Phosphorylation | SPKVSSPTKPKKTRQ CCCCCCCCCCCCCCC | 63.02 | 26745281 | |
230 | Phosphorylation | PKKTRQASSQGEEDG CCCCCCCCCCCCCCC | 18.17 | 23684622 | |
231 | Phosphorylation | KKTRQASSQGEEDGS CCCCCCCCCCCCCCC | 45.26 | 23684622 | |
256 | Phosphorylation | EGEDEEESEAPSENS ECCCHHHCCCCCCCC | 42.19 | - | |
593 | Phosphorylation | PLQRIRLSDGSLKLY CCCEEECCCCCEEEE | 30.03 | 25338131 | |
650 | Ubiquitination | YEPINCIKRFLSTEL CCCCCHHHHHHCCCC | 39.02 | - | |
695 | Phosphorylation | GYLGFKAYFTAPRKG CCCCEEEEEECCCCC | 11.31 | 23970565 | |
758 | Phosphorylation | YKADLIPYQDSPEDQ EECCCCCCCCCCCCC | 20.26 | 24759943 | |
761 | Phosphorylation | DLIPYQDSPEDQDYS CCCCCCCCCCCCCCC | 18.05 | 19060867 | |
767 | Phosphorylation | DSPEDQDYSSTSSET CCCCCCCCCCCCCCC | 10.01 | 21183079 | |
768 | Phosphorylation | SPEDQDYSSTSSETP CCCCCCCCCCCCCCC | 35.11 | 30635358 | |
769 | Phosphorylation | PEDQDYSSTSSETPN CCCCCCCCCCCCCCC | 26.53 | 19060867 | |
770 | Phosphorylation | EDQDYSSTSSETPNP CCCCCCCCCCCCCCC | 30.26 | 30635358 | |
771 | Phosphorylation | DQDYSSTSSETPNPP CCCCCCCCCCCCCCC | 28.29 | 30635358 | |
772 | Phosphorylation | QDYSSTSSETPNPPK CCCCCCCCCCCCCCC | 45.65 | 19060867 | |
774 | Phosphorylation | YSSTSSETPNPPKAR CCCCCCCCCCCCCCC | 30.25 | 19060867 | |
867 | Phosphorylation | HFVRGLTSPLAHRVQ EEECCCCCCCHHHHH | 23.98 | - | |
888 | Phosphorylation | FNAMFQPSFPTEGPG CCCCCCCCCCCCCCC | 32.83 | 25777480 | |
891 | Phosphorylation | MFQPSFPTEGPGFSP CCCCCCCCCCCCCCC | 52.11 | 26643407 | |
897 | Phosphorylation | PTEGPGFSPSSHCLL CCCCCCCCCCCCCCC | 29.77 | 26643407 | |
899 | Phosphorylation | EGPGFSPSSHCLLPN CCCCCCCCCCCCCCC | 31.36 | 26643407 | |
900 | Phosphorylation | GPGFSPSSHCLLPNP CCCCCCCCCCCCCCC | 22.92 | 26643407 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TF3C2_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TF3C2_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TF3C2_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
TF3C1_HUMAN | GTF3C1 | physical | 26496610 | |
MBP_HUMAN | MBP | physical | 26496610 | |
RL28_HUMAN | RPL28 | physical | 26496610 | |
TAF10_HUMAN | TAF10 | physical | 26496610 | |
ZMYM2_HUMAN | ZMYM2 | physical | 26496610 | |
TF3C5_HUMAN | GTF3C5 | physical | 26496610 | |
TF3C4_HUMAN | GTF3C4 | physical | 26496610 | |
TF3C3_HUMAN | GTF3C3 | physical | 26496610 | |
ADNP_HUMAN | ADNP | physical | 26496610 | |
S39AA_HUMAN | SLC39A10 | physical | 26496610 | |
PAPD5_HUMAN | PAPD5 | physical | 26496610 | |
ZMAT3_HUMAN | ZMAT3 | physical | 26496610 | |
CA131_HUMAN | C1orf131 | physical | 26496610 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND MASSSPECTROMETRY. |