MED19_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED19_MOUSE
• UniProt AC: Q8C1S0
• Protein Name: Mediator of RNA polymerase II transcription subunit 19
• Gene Name: Med19
• Organism: Mus musculus (Mouse).
• Sequence Length: 244
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)..
• Protein Sequence: MENFTALFGAQTDPPPPPSALGFGPGKPPPPPPPPPGGGPGAAPPSTATSAPAGADKSTAGSGPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPITGTMLSGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGMGSSQASSSSSLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MENFTALFGAQT ---CCCCCHHCCCCC	33.75	25338131
12	Phosphorylation	TALFGAQTDPPPPPS CHHCCCCCCCCCCCC	50.36	25338131
129	Phosphorylation	HDNSSLRSLIEKPPI CCCHHHHHHHHCCCC	38.70	24719451
184	Phosphorylation	HKHKQSRTQDPVPPE CCCCCCCCCCCCCCC	42.44	25619855
192	Phosphorylation	QDPVPPETPSDSDHK CCCCCCCCCCCCHHH	33.59	25619855
194	Phosphorylation	PVPPETPSDSDHKKK CCCCCCCCCCHHHHH	58.11	27087446
196	Phosphorylation	PPETPSDSDHKKKKK CCCCCCCCHHHHHHH	46.05	23684622
226	Phosphorylation	KKKKNRHSPDHPGMG HHHHCCCCCCCCCCC	28.87	23527152
234	Phosphorylation	PDHPGMGSSQASSSS CCCCCCCCCCCCCCC	15.47	27087446
235	Phosphorylation	DHPGMGSSQASSSSS CCCCCCCCCCCCCCC	24.84	25619855
238	Phosphorylation	GMGSSQASSSSSLR- CCCCCCCCCCCCCC-	24.10	25619855
239	Phosphorylation	MGSSQASSSSSLR-- CCCCCCCCCCCCC--	36.94	25619855
240	Phosphorylation	GSSQASSSSSLR--- CCCCCCCCCCCC---	22.81	25619855
241	Phosphorylation	SSQASSSSSLR---- CCCCCCCCCCC----	35.03	25619855
242	Phosphorylation	SQASSSSSLR----- CCCCCCCCCC-----	30.06	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED19_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED19_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED19_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MED19_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.