dbPTM

RIR2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RIR2_MOUSE
UniProt AC	P11157
Protein Name	Ribonucleoside-diphosphate reductase subunit M2
Gene Name	Rrm2
Organism	Mus musculus (Mouse).
Sequence Length	390
Subcellular Localization	Cytoplasm.
Protein Description	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity)..
Protein Sequence	MLSVRTPLATIADQQQLQLSPLKRLTLADKENTPPTLSSTRVLASKAARRIFQDSAELESKAPTNPSVEDEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREYLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPAEQRVREIITNAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSNSTENSFTLDADF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLSVRTPLAT -----CCCCCCCCCH	14.30	24759943
6	Phosphorylation	--MLSVRTPLATIAD --CCCCCCCCCHHCC	22.09	25619855
10	Phosphorylation	SVRTPLATIADQQQL CCCCCCCHHCCHHHH	25.12	25619855
20	Phosphorylation	DQQQLQLSPLKRLTL CHHHHCCCCCCCCCC	18.41	27087446
33	Phosphorylation	TLADKENTPPTLSST CCCCCCCCCCCCCHH	31.56	26824392
36	Phosphorylation	DKENTPPTLSSTRVL CCCCCCCCCCHHHHH	40.24	24453211
38	Phosphorylation	ENTPPTLSSTRVLAS CCCCCCCCHHHHHHH	31.94	25777480
39	Phosphorylation	NTPPTLSSTRVLASK CCCCCCCHHHHHHHH	24.28	26643407
40	Phosphorylation	TPPTLSSTRVLASKA CCCCCCHHHHHHHHH	22.78	26643407
55	Phosphorylation	ARRIFQDSAELESKA HHHHHHCCHHHHHCC	16.92	28066266
60	Phosphorylation	QDSAELESKAPTNPS HCCHHHHHCCCCCCC	46.90	28066266
61	Ubiquitination	DSAELESKAPTNPSV CCHHHHHCCCCCCCC	49.35	-
67	Phosphorylation	SKAPTNPSVEDEPLL HCCCCCCCCCCCCHH	39.96	26643407
377	Phosphorylation	YQRMGVMSNSTENSF HHHHCCCCCCCCCCE	25.81	26643407
379	Phosphorylation	RMGVMSNSTENSFTL HHCCCCCCCCCCEEC	29.77	26643407
380	Phosphorylation	MGVMSNSTENSFTLD HCCCCCCCCCCEECC	43.36	26643407
383	Phosphorylation	MSNSTENSFTLDADF CCCCCCCCEECCCCC	17.24	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
20	S	Phosphorylation	Kinase	CDK1	P06493	PSP
20	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
20	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
20	S	Phosphorylation		17242355
Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RIR2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RIR1_MOUSE	Rrm1	physical	16861739

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RIR2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, AND MASSSPECTROMETRY.	19131326 [Abstract]