dbPTM

LPXN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LPXN_MOUSE
UniProt AC	Q99N69
Protein Name	Leupaxin
Gene Name	Lpxn
Organism	Mus musculus (Mouse).
Sequence Length	386
Subcellular Localization	Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linki
Protein Description	Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling..
Protein Sequence	MEELDALLEELERCTFQDSEEYSNPVSCHLDQQSTEESKIPQTPKTLSSQGNTSPLKVQLVYATNIQEPNVYSEVQEPKESVLPPKTSAAAQLDELMAHLSEMQAKVSVKADTSRKPLPDQQDHKASLDSMLGDLEQELQDLGIATVPKGYCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEELGSSPFFERSGLAYCSKDYHRLFSPRCAYCAAPITDKVLTAMNKTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMNTVWHPECFVCGDCFSSFSSGSFFELDGRPFCELHYHHRRGTLCHDCGQPITGRCISAMGHKFHPEHFVCAFCLTQLPKGIFKEQNNKTYCEKCFTKLFSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEELDALL -------CHHHHHHH	9.01	-
15	Phosphorylation	LEELERCTFQDSEEY HHHHHHCCCCCCCHH	30.47	30635358
19	Phosphorylation	ERCTFQDSEEYSNPV HHCCCCCCCHHCCCC	22.88	30635358
22	Phosphorylation	TFQDSEEYSNPVSCH CCCCCCHHCCCCEEE	15.08	22817900
23	Phosphorylation	FQDSEEYSNPVSCHL CCCCCHHCCCCEEEC	37.63	25367039
27	Phosphorylation	EEYSNPVSCHLDQQS CHHCCCCEEECCCCC	9.33	25367039
34	Phosphorylation	SCHLDQQSTEESKIP EEECCCCCCCCCCCC	31.95	25367039
43	Phosphorylation	EESKIPQTPKTLSSQ CCCCCCCCCCCCCCC	22.77	25266776
46	Phosphorylation	KIPQTPKTLSSQGNT CCCCCCCCCCCCCCC	32.83	28833060
48	Phosphorylation	PQTPKTLSSQGNTSP CCCCCCCCCCCCCCC	26.33	28833060
49	Phosphorylation	QTPKTLSSQGNTSPL CCCCCCCCCCCCCCC	45.26	28833060
53	Phosphorylation	TLSSQGNTSPLKVQL CCCCCCCCCCCEEEE	38.25	30635358
54	Phosphorylation	LSSQGNTSPLKVQLV CCCCCCCCCCEEEEE	32.03	26824392
62	Phosphorylation	PLKVQLVYATNIQEP CCEEEEEEEECCCCC	19.12	25159016
64	Phosphorylation	KVQLVYATNIQEPNV EEEEEEEECCCCCCC	18.37	30635358
72	Phosphorylation	NIQEPNVYSEVQEPK CCCCCCCCCCCCCCH	13.02	25159016
73	Phosphorylation	IQEPNVYSEVQEPKE CCCCCCCCCCCCCHH	27.32	25159016
81	Phosphorylation	EVQEPKESVLPPKTS CCCCCHHHCCCCCCC	34.77	-
127	Phosphorylation	DQQDHKASLDSMLGD CCHHHHHHHHHHHCH	37.20	20531401
130	Phosphorylation	DHKASLDSMLGDLEQ HHHHHHHHHHCHHHH	22.62	20531401
187	Phosphorylation	HCKEELGSSPFFERS CCHHHHCCCCCHHHC	47.68	26745281
188	Phosphorylation	CKEELGSSPFFERSG CHHHHCCCCCHHHCC	24.75	27180971
199	Glutathionylation	ERSGLAYCSKDYHRL HHCCCEEECCCHHHH	3.20	24333276
203	Phosphorylation	LAYCSKDYHRLFSPR CEEECCCHHHHCCCC	7.80	29895711
208	Phosphorylation	KDYHRLFSPRCAYCA CCHHHHCCCCCCCCC	18.94	29895711
213	Phosphorylation	LFSPRCAYCAAPITD HCCCCCCCCCCCCCH	6.05	-
267	Phosphorylation	KDFLAMFSPKCGGCN HHHHHHHCCCCCCCC	15.46	26745281
329	Glutathionylation	HHRRGTLCHDCGQPI ECCCCCEECCCCCCC	2.27	24333276
332	Glutathionylation	RGTLCHDCGQPITGR CCCEECCCCCCCCCC	2.13	24333276
342	Phosphorylation	PITGRCISAMGHKFH CCCCCHHHHCCCCCC	18.81	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
72	Y	Phosphorylation	Kinase	LYN	P07948	PSP
72	Y	Phosphorylation	Kinase	LYN	P25911	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LPXN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LPXN_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LPXN_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LPXN_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling."; Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.; J. Immunol. 179:5864-5876(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-22; TYR-62 AND TYR-72,AND MASS SPECTROMETRY.	17947660 [Abstract]
"Leupaxin negatively regulates B cell receptor signaling."; Chew V., Lam K.P.; J. Biol. Chem. 282:27181-27191(2007). Cited for: FUNCTION, PHOSPHORYLATION AT TYR-72 BY LYN, AND INTERACTION WITH LYN.	17640867 [Abstract]