RAC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAC2_MOUSE
• UniProt AC: Q05144
• Protein Name: Ras-related C3 botulinum toxin substrate 2
• Gene Name: Rac2
• Organism: Mus musculus (Mouse).
• Sequence Length: 192
• Subcellular Localization: Cytoplasm. Membrane; Lipid-anchor. Membrane-associated when activated..
• Protein Description: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase..
• Protein Sequence: MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKDIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRPCSLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	GDGAVGKTCLLISYT CCCCCCCEEEEEEEE	11.49	-
22	Phosphorylation	GKTCLLISYTTNAFP CCEEEEEEEECCCCC	19.18	-
23	Phosphorylation	KTCLLISYTTNAFPG CEEEEEEEECCCCCC	15.58	-
24	Phosphorylation	TCLLISYTTNAFPGE EEEEEEEECCCCCCC	13.54	-
64	Phosphorylation	DTAGQEDYDRLRPLS CCCCCCCHHHCCCCC	11.38	-
105	Glutathionylation	FPEVRHHCPSTPIIL CHHHHHHCCCCCEEE	2.02	24333276
107	Phosphorylation	EVRHHCPSTPIILVG HHHHHCCCCCEEEEE	52.81	24719451
116	Ubiquitination	PIILVGTKLDLRDDK CEEEEEECCCCCCCH	33.79	-
123	Ubiquitination	KLDLRDDKDTIEKLK CCCCCCCHHHHHHHH	62.15	22790023
125	Phosphorylation	DLRDDKDTIEKLKEK CCCCCHHHHHHHHHC	36.45	29899451
128	Ubiquitination	DDKDTIEKLKEKKLA CCHHHHHHHHHCCCC	62.09	22790023
147	Ubiquitination	PQGLALAKDIDSVKY HHHHHHHCCCCCCCE	56.94	27667366
147	Acetylation	PQGLALAKDIDSVKY HHHHHHHCCCCCCCE	56.94	-
153	Ubiquitination	AKDIDSVKYLECSAL HCCCCCCCEEEHHHH	48.33	-
157	S-nitrosylation	DSVKYLECSALTQRG CCCCEEEHHHHHHHH	2.38	22588120
157	Glutathionylation	DSVKYLECSALTQRG CCCCEEEHHHHHHHH	2.38	24333276
157	S-palmitoylation	DSVKYLECSALTQRG CCCCEEEHHHHHHHH	2.38	28526873
158	Phosphorylation	SVKYLECSALTQRGL CCCEEEHHHHHHHHH	19.55	20531401
161	Phosphorylation	YLECSALTQRGLKTV EEEHHHHHHHHHHHH	18.88	22817900
166	Ubiquitination	ALTQRGLKTVFDEAI HHHHHHHHHHHHHHH	45.53	27667366
167	Phosphorylation	LTQRGLKTVFDEAIR HHHHHHHHHHHHHHH	31.29	25177544
178	Glutathionylation	EAIRAVLCPQPTRQQ HHHHHHHCCCCCCCC	2.06	24333276
189	Geranylgeranylation	TRQQKRPCSLL---- CCCCCCCCCCC----	5.34	-
189	Methylation	TRQQKRPCSLL---- CCCCCCCCCCC----	5.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RAC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.