COPG2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPG2_MOUSE
• UniProt AC: Q9QXK3
• Protein Name: Coatomer subunit gamma-2
• Gene Name: Copg2
• Organism: Mus musculus (Mouse).
• Sequence Length: 871
• Subcellular Localization: Cytoplasm, cytosol . Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplas
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)..
• Protein Sequence: MIKKFDKKDEESGSGSNPFQHLEKSAVLQEARIFNETPINPRRCLHILTKILYLLNQGEHFGTMEATEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISEDVIIVTSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQAVERYMKQAIVDKVSSVASSALVSSLHMMKISYDVVKRWINEAQEAASSDNIMVQYHALGVLYHLRKNDRLAVSKMLNKFTKSGLKSQFAYCMLIRIASRLLKESEDGHESPLFDFIESCLRNKHEMVIYEAASAIIHLPNCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCHKYPRKHSVMMTFLSNMLRDDGGFEYKKAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGPRTPVPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNESLLPSILVLLQRCMMDTDDEVRDRATFYLNVLQQRQMALNATYIFNGLTVSIPGMEKALHQYTLEPSEKPFDMKSIPLAMAPVFEQKSEITLVTPKPEKLAPSRQDIFQEQLAAIPEFMNLGPLFKSSEPVQLTEAETEYFVRCVKHMFTDHIVFQFDCTNTLNDQLLEKVTVQMEPSDSYEVLCCIPAPSLPYNQPGICYTLVRLPDEDPTAVAGTFSCTMKFTVRDCDPNTGVPDEDGYDDEYVLEDLEVTVSDHIQKILKPNFAAAWEEVGDAFEKEETFALSSTKTLEEAVNNIITFLGMQPCERSDKVPENKNSHSLYLAGVYRGGYDLLVRSRLALADGVTMQVTVRSKERTPVDVILASVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
175	Malonylation	KISYDVVKRWINEAQ HCCHHHHHHHHHHHH	41.69	26320211
213	Ubiquitination	NDRLAVSKMLNKFTK CCHHHHHHHHHHHHH	40.59	27667366
250	Ubiquitination	SEDGHESPLFDFIES CCCCCCCHHHHHHHH	33.78	27667366
290	Phosphorylation	RELAPAVSVLQLFCS HHHHHHHHHHHHHHC	21.15	24719451
296	Glutathionylation	VSVLQLFCSSPKPAL HHHHHHHHCCCCHHH	5.53	24333276
317	Acetylation	TLNKVAMKHPSAVTA HHHHHHHHCCCHHCC	42.50	22826441
355	Phosphorylation	LLKTGSESSVDRLMK HHHHCCHHHHHHHHH	37.04	23684622
395	Phosphorylation	HKYPRKHSVMMTFLS HHCCCCCHHHHHHHH	18.10	22871156
449	Phosphorylation	FIEDCEHTVLATKIL HHHHCCHHHHHHHHH	8.57	28285833
453	Phosphorylation	CEHTVLATKILHLLG CCHHHHHHHHHHHHC	17.92	28285833
461	Ubiquitination	KILHLLGKEGPRTPV HHHHHHCCCCCCCCC	60.51	27667366
470	Phosphorylation	GPRTPVPSKYIRFIF CCCCCCCHHHHHHHH	38.02	-
471	Ubiquitination	PRTPVPSKYIRFIFN CCCCCCHHHHHHHHH	38.33	27667366
498	Ubiquitination	AVSALAKFGAQNESL HHHHHHHCCCCCCCH	9.02	27667366
508	Ubiquitination	QNESLLPSILVLLQR CCCCHHHHHHHHHHH	28.64	27667366
591	Phosphorylation	APVFEQKSEITLVTP CCCCCCCCEEEEECC	33.65	26745281
594	Phosphorylation	FEQKSEITLVTPKPE CCCCCEEEEECCCHH	15.89	26745281
597	Phosphorylation	KSEITLVTPKPEKLA CCEEEEECCCHHHCC	28.80	26745281
715	Phosphorylation	RLPDEDPTAVAGTFS ECCCCCCCCCCEEEE	46.19	27841257
720	Phosphorylation	DPTAVAGTFSCTMKF CCCCCCEEEEEEEEE	11.57	27841257
722	Phosphorylation	TAVAGTFSCTMKFTV CCCCEEEEEEEEEEE	14.44	27841257
824	Phosphorylation	PENKNSHSLYLAGVY CCCCCCCCEEEEEEE	20.66	-
826	Phosphorylation	NKNSHSLYLAGVYRG CCCCCCEEEEEEECC	9.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPG2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPG2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPG2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of COPG2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.