CENPQ_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CENPQ_MOUSE
• UniProt AC: Q9CPQ5
• Protein Name: Centromere protein Q
• Gene Name: Cenpq
• Organism: Mus musculus (Mouse).
• Sequence Length: 267
• Subcellular Localization: Nucleus . Chromosome, centromere . Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
• Protein Description: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores..
• Protein Sequence: MSGKARASRKKPQQVKRSLKQRANKEADLPENEVGNTAKRNRSHAKHLSSKVTGQATYVHLKRVKISSSKRTTWQPLPKDTEEYLQSMMESVILGILFNIKRKEEIQCHLNQLKKRLLQQCATLKVPPRKLNYLKDVSKMLKMEKAQERANEESLASLQEEIDKIVETTESMTESIQSLKNKIQILTSEVEEEEQEVKQVFHIDSNKVLALPELSQKSLKAPILQEEILALIPNQNALLKDLDVLHDSAPVKNVSAFIEEAYKKLDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	RSHAKHLSSKVTGQA HHHHHHHHHCCCCCC	31.56	-
72	Phosphorylation	KISSSKRTTWQPLPK EECCCCCCCCCCCCC	56.57	28576409
73	Phosphorylation	ISSSKRTTWQPLPKD ECCCCCCCCCCCCCC	39.06	28576409
187	Phosphorylation	KNKIQILTSEVEEEE HHHHHHHHHHHHHHH	5.29	30635358
188	Phosphorylation	NKIQILTSEVEEEEQ HHHHHHHHHHHHHHH	2.18	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CENPQ_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
49	S	Phosphorylation	Phosphorylation at Ser-49 is essential for CENPE recruitment to kinetochores and orderly chromosome congression.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CENPQ_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAF_HUMAN	BANF1	physical	26496610
LTMD1_HUMAN	LETMD1	physical	26496610
LTN1_HUMAN	LTN1	physical	26496610
TANC2_HUMAN	TANC2	physical	26496610
FGD6_HUMAN	FGD6	physical	26496610
CENPO_HUMAN	CENPO	physical	26496610
CENPU_HUMAN	CENPU	physical	26496610
CENPP_HUMAN	CENPP	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.