ATAD5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATAD5_MOUSE
• UniProt AC: Q4QY64
• Protein Name: ATPase family AAA domain-containing protein 5
• Gene Name: Atad5
• Organism: Mus musculus (Mouse).
• Sequence Length: 1826
• Subcellular Localization: Nucleus .
• Protein Description: Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis..
• Protein Sequence: MVGVLSMAAAAAPLPVKDYEIEPCKKRRKDDDNSSCETITKYLSPIGKTGDKVFSPPKPSNILHYFRKTSLTTEKPQSTKAYKIKPSPPLLVGNSKDCKTPLEVFSNREFKRKRKRVSLSSQLNDIKIQDECPVEISNNDSKEDGGLSDCVESSASVSLYKEHVEVLAESIEDSRNQPNTKSSKKKVNPKQCTTKSDDRILRKRKRSKVTGQSESVPLADELSLPEDGGKDSKLTKPSLAEENDSRTHATKRADLKESTITVSYEEFVKSHKAAKVEEIPDPAVPACVPSGPGEAVKSGSEGELSGSCEPSPQLHLKTVTVLAQVHPTPPKKKGKIPPIFLKQKQPELENSLSDPENEQPVQKRKSNVVIQEGQLELAVLEAWNSEASVPKCSMEERQQFMRAFRQPPPDTLKNGFKKPLEKQKDPSEKSVHEGDSSSEKIIENPNIQRVSSQGCLQSHADRGSFPKEKSKKPNKKGKKTRTTAGGNREENIQKEKTAFSLKDEQDQNSLRRSVRQKSEVLKSNALLNSENLVCEDTAHDSVQMSLCNRNKSRSSSTPTRDMVTHHRAEPGSSLEYVSTRQPIRRSLRSCSTPATNALGGTESEDAQDTIPVKASTPKSARTSEKHNLYTAELIIVSSDSESPIRMKFTRISTPKKSKKSSKKSETTEEELTSQKKKANSTSKNISKAKELIEEAKAFQIGGSKTEETVVPLRRSSRHQARSAKEKSPEIDDSVIVIDSSPTSIREPEKSQKKLQNLNDVLGKKLNKSSKNVPGKMKIAPLFLAKRTKRAAIPVFDLDESSQDSSEQTQDCDVQFKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDEYWLWHLKPPSCPLLTEFKELNTKVTDLSEYVVAFGEFSTLNPNPRSNPAAVMMRTRKDFTKEVRNLLLEEIKCSNPEFSLEKYFPLLLKKRIEHQVLCEGHGKQASPQLQPDVSQKETKRKQVATGNQKSKRKRQNEYSVSPEEMKGRSKDLDERISSSCTNLDPSRDSGTEDMLWTEKYQPQNSNELIGNELAVKKLHSWLKDWKRRAELEERHNLKGKRDEKEEGILDLSDSTDFKGSSDDEENRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNNYNIGKSPKKLNSPGKVVTSPRKLPPSSPKTSGQKRALLPKTLANYFKVSSKSKSNDDVGALMGDDKGVKNSSLEQRQLIQTKSTNANNSHIKDVGAEESNRKKATSLILFEEVDVIFDEDAGFLNAVKTFMATTKRPVILTTSDPTFSLVFDGCFEEINFSIPSLLNVASYLQVICLVENFRTDFKDFVTLLTANACDIRKSILYLQFWIRSGGGILEERPLSHCRENSRNTLVCSEDGSDANINSKKPKRNRVALPRCDTGCAEALFGLKNIASPSQDLLSLLKHKITTKEEWQKLIQVLTEFHVQNIDLLHSNLEVILPLPVHVVPDVRGAYGFPVTTQASAPASMGHLTRKQSKDQPLRKSQKRKQKKMVILDDSDLFDTGLDFSGELPSLSPAPSLSVEDNIRRDSNPEIKTQNSGFKPHSVPQPPKTLAEKKCCMLVSHCLNSLSEFMENMSFIDALLTDPGEQNELGRSAFHWTNGRVKSGLCDEFSLENRDRWAPQSAGELKATAEALSFTECSSTISKALESLNSCKQLERDPTNELTVCVSQRRHDACFRQSAANLDNADKRMAVIKSVFSSRSFLTLGNKQASIIDYLPTLRNICRTEKLKEQEKNKRRFLHYFEGIHLEIPEETITTLAADFP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Acetylation	SSCETITKYLSPIGK CCHHHHHHHHCCCCC	40.10	19855031
44	Phosphorylation	ETITKYLSPIGKTGD HHHHHHHCCCCCCCC	16.04	22817900
55	Phosphorylation	KTGDKVFSPPKPSNI CCCCCCCCCCCCCCH	43.19	23984901
69	Phosphorylation	ILHYFRKTSLTTEKP HHHHHHHCCCCCCCC	25.39	25266776
70	Phosphorylation	LHYFRKTSLTTEKPQ HHHHHHCCCCCCCCC	27.10	25266776
75	Acetylation	KTSLTTEKPQSTKAY HCCCCCCCCCCCCCE	46.38	23806337
87	Phosphorylation	KAYKIKPSPPLLVGN CCEECCCCCCEEECC	33.86	25159016
118	Phosphorylation	KRKRKRVSLSSQLND HHHHHCCCHHHHCCC	26.94	27600695
120	Phosphorylation	KRKRVSLSSQLNDIK HHHCCCHHHHCCCCC	14.45	28066266
121	Phosphorylation	RKRVSLSSQLNDIKI HHCCCHHHHCCCCCC	43.94	28066266
215	Phosphorylation	KVTGQSESVPLADEL CCCCCCCCCCCCHHC	33.99	-
223	Phosphorylation	VPLADELSLPEDGGK CCCCHHCCCCCCCCC	39.57	21149613
238	Phosphorylation	DSKLTKPSLAEENDS CCCCCCCCHHCCCCC	41.59	20139300
258	Phosphorylation	KRADLKESTITVSYE HHHHCCCCEEEEEHH	24.42	20139300
263	Phosphorylation	KESTITVSYEEFVKS CCCEEEEEHHHHHHH	20.41	20139300
264	Phosphorylation	ESTITVSYEEFVKSH CCEEEEEHHHHHHHC	18.36	20139300
305	Phosphorylation	SGSEGELSGSCEPSP CCCCCCCCCCCCCCC	25.10	21183079
311	Phosphorylation	LSGSCEPSPQLHLKT CCCCCCCCCCCEEEE	11.73	22817900
328	Phosphorylation	VLAQVHPTPPKKKGK EEEECCCCCCCCCCC	37.03	26643407
351	Phosphorylation	KQPELENSLSDPENE CCHHHHHCCCCCCCC	21.63	22942356
353	Phosphorylation	PELENSLSDPENEQP HHHHHCCCCCCCCCC	51.44	26824392
366	Phosphorylation	QPVQKRKSNVVIQEG CCCHHHHCCEEEECC	38.60	27600695
436	Phosphorylation	KSVHEGDSSSEKIIE CCCCCCCCCCHHHHC	46.77	27841257
451	Phosphorylation	NPNIQRVSSQGCLQS CCCCEEECCCCCHHH	21.09	28066266
452	Phosphorylation	PNIQRVSSQGCLQSH CCCEEECCCCCHHHH	27.95	25159016
556	Phosphorylation	RNKSRSSSTPTRDMV CCCCCCCCCCCHHHH	39.39	25338131
557	Phosphorylation	NKSRSSSTPTRDMVT CCCCCCCCCCHHHHH	30.54	25338131
591	Phosphorylation	RRSLRSCSTPATNAL HHHHHHCCCCCCCCC	38.38	25338131
603	Phosphorylation	NALGGTESEDAQDTI CCCCCCCCCCCCCCC	40.38	-
615	Phosphorylation	DTIPVKASTPKSART CCCCCCCCCCCCCCC	39.25	30482847
616	Phosphorylation	TIPVKASTPKSARTS CCCCCCCCCCCCCCH	39.33	24453211
687	Acetylation	STSKNISKAKELIEE CCCCCHHHHHHHHHH	60.73	7714011
689	Acetylation	SKNISKAKELIEEAK CCCHHHHHHHHHHHH	57.71	7714021
696	Acetylation	KELIEEAKAFQIGGS HHHHHHHHHHCCCCC	53.68	7714031
705	Phosphorylation	FQIGGSKTEETVVPL HCCCCCCCCCCEEEC	40.53	26239621
708	Phosphorylation	GGSKTEETVVPLRRS CCCCCCCCEEECCCH	22.14	26239621
727	Phosphorylation	ARSAKEKSPEIDDSV HHHHHHCCCCCCCCE	28.93	26824392
733	Phosphorylation	KSPEIDDSVIVIDSS CCCCCCCCEEEECCC	15.25	22942356
739	Phosphorylation	DSVIVIDSSPTSIRE CCEEEECCCCCCCCC	27.39	25619855
740	Phosphorylation	SVIVIDSSPTSIREP CEEEECCCCCCCCCC	28.57	23375375
742	Phosphorylation	IVIDSSPTSIREPEK EEECCCCCCCCCCHH	38.44	25619855
743	Phosphorylation	VIDSSPTSIREPEKS EECCCCCCCCCCHHH	24.04	25619855
800	Phosphorylation	PVFDLDESSQDSSEQ EEEECCCCCCCCCHH	32.73	25619855
801	Phosphorylation	VFDLDESSQDSSEQT EEECCCCCCCCCHHH	35.64	25619855
804	Phosphorylation	LDESSQDSSEQTQDC CCCCCCCCCHHHCCC	28.30	25619855
805	Phosphorylation	DESSQDSSEQTQDCD CCCCCCCCHHHCCCC	41.85	25619855
808	Phosphorylation	SQDSSEQTQDCDVQF CCCCCHHHCCCCCHH	23.48	25168779
969	Phosphorylation	EGHGKQASPQLQPDV CCCCCCCCCCCCCCC	15.64	22942356
977	Phosphorylation	PQLQPDVSQKETKRK CCCCCCCCHHHHHHH	42.80	22817900
1001	Phosphorylation	KRKRQNEYSVSPEEM HHHHHCCCCCCHHHH	23.17	28066266
1002	Phosphorylation	RKRQNEYSVSPEEMK HHHHCCCCCCHHHHC	15.22	28066266
1004	Phosphorylation	RQNEYSVSPEEMKGR HHCCCCCCHHHHCCC	22.21	27600695
1103	Phosphorylation	DSTDFKGSSDDEENR CCCCCCCCCCHHHCC	31.05	27841257
1104	Phosphorylation	STDFKGSSDDEENRL CCCCCCCCCHHHCCC	58.72	27841257
1188	Phosphorylation	NNYNIGKSPKKLNSP CCCCCCCCCCCCCCC	36.42	25159016
1194	Phosphorylation	KSPKKLNSPGKVVTS CCCCCCCCCCCEEEC	45.53	21082442
1200	Phosphorylation	NSPGKVVTSPRKLPP CCCCCEEECCCCCCC	35.68	21659605
1201	Phosphorylation	SPGKVVTSPRKLPPS CCCCEEECCCCCCCC	15.88	25266776
1208	Phosphorylation	SPRKLPPSSPKTSGQ CCCCCCCCCCCCCCC	58.28	28066266
1209	Phosphorylation	PRKLPPSSPKTSGQK CCCCCCCCCCCCCCC	35.87	28066266
1592	Phosphorylation	EDNIRRDSNPEIKTQ HHCCCCCCCCCCCCC	53.09	27841257
1686	Phosphorylation	RDRWAPQSAGELKAT CCCCCCCCHHHHHHH	36.86	22817900
1724	Phosphorylation	KQLERDPTNELTVCV CHHCCCCCCCCEEEE	45.69	22802335
1728	Phosphorylation	RDPTNELTVCVSQRR CCCCCCCEEEEHHHH	12.99	22802335
1732	Phosphorylation	NELTVCVSQRRHDAC CCCEEEEHHHHHHHH	16.91	22802335

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATAD5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATAD5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATAD5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ATAD5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.