ELF4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELF4_MOUSE
• UniProt AC: Q9Z2U4
• Protein Name: ETS-related transcription factor Elf-4
• Gene Name: Elf4 {ECO:0000312|MGI:MGI:1928377}
• Organism: Mus musculus (Mouse).
• Sequence Length: 655
• Subcellular Localization: Nucleus, PML body. Accumulation into PML nuclear bodies is mediated by PML..
• Protein Description: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway..
• Protein Sequence: MAIALQPSDLVFEFASNGMDDIHQLEDPSVFPAVIVEQVPYPELVHLCSGLDLDEVHNGIIRDRTLCMTQDQILEGSILLTDDDVSTSNNVSSTEVLFNVATPSDVLDEKQIFSSPEVLSDSNSVQAINLPNFLLSTPEPDDLKKTSDAGDQKEHSEEEKVSREENLRKMGKARKRNRKTKNNRSTSPVTDPSMPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLVVIDDEEESPETPEDSSQASTSSTPSTSTIRRASSRVGTRASPEDKDNPPWEKPKVQHTGLQPSASLELGLSVDEEVPTTSTMLASPLQSQARLTKTVSSSPAPSNIHLGVAPVGPGSTVTLQTIPLTTVLTNGPPASTTAPTQLVLQSVPQVSTFKDTFTLQTSFPLNTNLQENQVATQGAPLILSGLPQLLAGANPQSNPAPSQVIGAGSAGPSSQPPGTVIAAFIRTSSGTSVPVVKEGPLRSSSYVQGVVTGAPVEGLLVPEETLRELLRDQGHLQPLPSQVLSRGSHNLSLVGNQTLSPPSHPTVGLTPVAELELSSGSGPLFVTEPSVTRSPTQAPFSPFNPTSLIKMEPQDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
124	Phosphorylation	EVLSDSNSVQAINLP HHHCCCCCEEEECCC	21.40	28285833
156	Phosphorylation	AGDQKEHSEEEKVSR CCCHHHCCHHHHHHH	48.04	29176673
185	Phosphorylation	RKTKNNRSTSPVTDP CCCCCCCCCCCCCCC	35.05	22942356
186	Phosphorylation	KTKNNRSTSPVTDPS CCCCCCCCCCCCCCC	33.54	22802335
187	Phosphorylation	TKNNRSTSPVTDPSM CCCCCCCCCCCCCCC	20.72	26824392
190	Phosphorylation	NRSTSPVTDPSMPIR CCCCCCCCCCCCCCC	45.64	25619855
193	Phosphorylation	TSPVTDPSMPIRKKS CCCCCCCCCCCCCCC	39.75	22817900
308	Phosphorylation	DEEESPETPEDSSQA CCCCCCCCCCCCCCC	35.05	25338131
335	Phosphorylation	RASSRVGTRASPEDK HHHCCCCCCCCCCCC	21.87	25159016
338	Phosphorylation	SRVGTRASPEDKDNP CCCCCCCCCCCCCCC	26.07	25159016
526	Phosphorylation	VIAAFIRTSSGTSVP EEEEEEECCCCCCCC	23.56	30635358
527	Phosphorylation	IAAFIRTSSGTSVPV EEEEEECCCCCCCCE	19.54	27600695
528	Phosphorylation	AAFIRTSSGTSVPVV EEEEECCCCCCCCEE	45.54	25266776
544	Phosphorylation	EGPLRSSSYVQGVVT ECCCCCCCCCCEEEC	30.48	24719451
545	Phosphorylation	GPLRSSSYVQGVVTG CCCCCCCCCCEEECC	9.95	25266776
633	Phosphorylation	TEPSVTRSPTQAPFS ECCCCCCCCCCCCCC	23.96	21082442
635	Phosphorylation	PSVTRSPTQAPFSPF CCCCCCCCCCCCCCC	38.31	22942356
640	Phosphorylation	SPTQAPFSPFNPTSL CCCCCCCCCCCCCHH	27.76	28833060

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELF4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELF4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELF4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ELF4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.