ZN638_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN638_MOUSE
• UniProt AC: Q61464
• Protein Name: Zinc finger protein 638 {ECO:0000312|MGI:MGI:1203484}
• Gene Name: Znf638 {ECO:0000250|UniProtKB:Q14966}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1960
• Subcellular Localization: Nucleus speckle .
• Protein Description: Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1. [PubMed: 21602272 Binds to cytidine clusters in double-stranded DNA (By similarity May also regulate alternative splicing of target genes during adipogenesis]
• Protein Sequence: MSRPRFNPRGTFPLQRPRAPNPPGMRPPGPFVRPGSMGLPRFYPAGRARGIPHRFPGHGSYQNMGPQRMNVQVTQHRTDPRLTKEKLDFPEAQQKKGKPHGSRWDDESHITPPVEVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMRKMSRRLPNLPSHSRNKETLSNETVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVKNEFQPQQSISATVSTPNVICNSVFPGGDMFRQMDFPGESSSQSFFPVESGTKMSGLHISGQSVLEPVKSISQSISQTVSQTTSQSLNPPSMNQVPFTFELDAVLRQQERISQKSVISSADAHGGPTESKKDYQSEADLPIRSPFGIVKASWLPKFTQAGAQKMKRLPTPSMMNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNESNRKENETPRRRSHSPSPRHSRRSSSGHRIRRSRSPVRYIYRPRSRSPRICHRFISKYRSRSRSRSRSRSPYRSRNLLRRSPKSYRSASPERTSRKSVRSDRKKALEDGGQRSVHGTEVTKQKHTETVDKGLSPAQKPKLASGTKPSAKSLSSVKSDSHLGAYSAHKSENLEDDTLPEGKQESGKSALAQRKPQKDQSLSSNSILLVSELPEDGFTEEDIRKAFLPFGKISDVLLVPCRNEAYLEMELRKAVTSIMKYIETMPLVIKGKSVKVCVPGKKKPQNKEMKKKPSDIKKSSASALKKETDASKTMETVSSSSSAKSGQIKSSTVKVNKCAGKSAGSVKSVVTVAAKGKASIKTAKSGKKSLEAKKSGNIKNKDSNKPVTVPANSEIKASSEDKATGKSAEESPSGTLEATEKEPVNKESEEMSVVFISNLPNKGYSTEEIYNLAKPFGALKDILVLSSHKKAYIEINKKSADSMVKFYTCFPISMDGNQLSISMAPEHVDLKDEEALFTTLIQENDPEANIDKIYNRFVHLDNLPEDGLQCVLCVGHQFGKVDRYMFMSNKNKVILQLESPESALSMYNFLKQNPQNIGEHVLTCTLSPKTDSEVQRKNDLELGKGSTFSPDLKNSPVDESEVQTAADSSSVKPSEVEEETTSNIGTETSVHQEELGKEEPKQALCESDFAIQTLELEAQGAEVSIEIPLVASTPANIELFSENIDESALNQQMYTSDFEKEEAEVTNPETELAVSDSVFIEERNIKGIIEDSPSETEDIFSGIVQPMVDAIAEVDKHETVSEVLPSACNVTQAPGSYIEDEKVVSKKDIAEKVILDEKEEDEFNVKETRMDLQVKTEKAEKNEAIIFKEKLEKIIAAIREKPIESSVIKADPTKGLDQTSKPDETGKSSVLTVSNVYSSKSSIKATVVSSPKAKSTPSKTESHSTFPKPVLREQIKADKKVSAKEFGLLKNTRSGLAESNSKSKPTQIGVNRGCSGRISALQCKDSKVDYKDITKQSQETETKPPIMKRDDSNNKALALQNTKNSKSTTDRSSKSKEEPLFTFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKEALKISPSPELNLKKKKGKTSVPHSVEGELSFVTLDEIGEEEDATVQALVTVDEVIDEEELNMEEMVKNSNSLLTLDELIDQDDCIPHSGPKDVTVLSMAEEQDLQQERLVTVDEIGEVEESADITFATLNAKRDKRDSIGFISSQMPEDPSTLVTVDEIQDDSSDFHLMTLDEVTEEDENSLADFNNLKEELNFVTVDEVGDEEDGDNDSKVELARGKIEHHTDKKGNRKRRAVDPKKSKLDSFSQVGPGSETVTQKDLKTMPERHLAAKTPMKRVRLGKSSPSQKVAEPTKGEEAFQMSEGVDDAELKDSEPDEKRRKTQDSSVGKSMTSDVPGDLDFLVPKAGFFCPICSLFYSGEKAMANHCKSTRHKQNTEKFMAKQRKEKEQNETEERSSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Asymmetric dimethylarginine	PRFYPAGRARGIPHR CCCCCCCCCCCCCCC	24.18	-
47	Methylation	PRFYPAGRARGIPHR CCCCCCCCCCCCCCC	24.18	-
49	Asymmetric dimethylarginine	FYPAGRARGIPHRFP CCCCCCCCCCCCCCC	42.06	-
49	Methylation	FYPAGRARGIPHRFP CCCCCCCCCCCCCCC	42.06	-
54	Asymmetric dimethylarginine	RARGIPHRFPGHGSY CCCCCCCCCCCCCCC	33.82	-
54	Methylation	RARGIPHRFPGHGSY CCCCCCCCCCCCCCC	33.82	-
108	Phosphorylation	GSRWDDESHITPPVE CCCCCCCCCCCCCEE	27.47	28066266
111	Phosphorylation	WDDESHITPPVEVKQ CCCCCCCCCCEEEEC	19.00	19060867
120	Phosphorylation	PVEVKQSSVTQVTEQ CEEEECCCCEEECCC	27.04	23984901
122	Phosphorylation	EVKQSSVTQVTEQSP EEECCCCEEECCCCC	21.19	23984901
125	Phosphorylation	QSSVTQVTEQSPKVQ CCCCEEECCCCCCHH	20.63	25159016
128	Phosphorylation	VTQVTEQSPKVQSRY CEEECCCCCCHHCCC	22.06	25521595
133	Phosphorylation	EQSPKVQSRYTKESA CCCCCHHCCCCHHHH	30.18	26745281
158	Phosphorylation	NEDLEELSRYPDEQL HHHHHHHHCCCHHHC	32.80	-
247	Phosphorylation	NEFQPQQSISATVST CCCCCCCCEEEEECC	17.17	26060331
249	Phosphorylation	FQPQQSISATVSTPN CCCCCCEEEEECCCC	24.12	26060331
251	Phosphorylation	PQQSISATVSTPNVI CCCCEEEEECCCCEE	14.27	26060331
253	Phosphorylation	QSISATVSTPNVICN CCEEEEECCCCEEEC	33.52	26060331
254	Phosphorylation	SISATVSTPNVICNS CEEEEECCCCEEECC	17.97	26060331
288	Phosphorylation	QSFFPVESGTKMSGL CCEEECCCCCCCEEE	52.58	-
298	Phosphorylation	KMSGLHISGQSVLEP CCEEEEECCCCHHHC	21.74	-
357	Phosphorylation	SQKSVISSADAHGGP CCCHHHCCHHCCCCC	21.02	25338131
367	Phosphorylation	AHGGPTESKKDYQSE CCCCCCCCHHHHHCC	47.70	-
371	Phosphorylation	PTESKKDYQSEADLP CCCCHHHHHCCCCCC	23.87	28725479
373	Phosphorylation	ESKKDYQSEADLPIR CCHHHHHCCCCCCCC	28.64	25159016
381	Phosphorylation	EADLPIRSPFGIVKA CCCCCCCCCCCEEEH	25.87	26824392
414	Phosphorylation	TPSMMNDYYAASPRI CHHHHCCHHHCCCCH	7.04	-
415	Phosphorylation	PSMMNDYYAASPRIF HHHHCCHHHCCCCHH	9.88	-
418	Phosphorylation	MNDYYAASPRIFPHL HCCHHHCCCCHHHHH	13.41	26745281
486	Phosphorylation	NETPRRRSHSPSPRH CCCCCCCCCCCCCCC	26.89	29899451
488	Phosphorylation	TPRRRSHSPSPRHSR CCCCCCCCCCCCCCC	28.46	22324799
490	Phosphorylation	RRRSHSPSPRHSRRS CCCCCCCCCCCCCCC	37.27	29899451
494	Phosphorylation	HSPSPRHSRRSSSGH CCCCCCCCCCCCCCC	30.57	22705319
506	Phosphorylation	SGHRIRRSRSPVRYI CCCCCCCCCCCCEEE	27.54	23737553
508	Phosphorylation	HRIRRSRSPVRYIYR CCCCCCCCCCEEEEC	29.06	23737553
518	Phosphorylation	RYIYRPRSRSPRICH EEEECCCCCCHHHHH	39.53	19854140
520	Phosphorylation	IYRPRSRSPRICHRF EECCCCCCHHHHHHH	21.56	19854140
539	Phosphorylation	RSRSRSRSRSRSPYR HHHCCCCCCCCCCHH	35.54	27681418
541	Phosphorylation	RSRSRSRSRSPYRSR HCCCCCCCCCCHHHH	38.05	23737553
543	Phosphorylation	RSRSRSRSPYRSRNL CCCCCCCCCHHHHHH	27.77	23737553
545	Phosphorylation	RSRSRSPYRSRNLLR CCCCCCCHHHHHHHH	23.59	23737553
547	Phosphorylation	RSRSPYRSRNLLRRS CCCCCHHHHHHHHCC	21.48	28059163
554	Phosphorylation	SRNLLRRSPKSYRSA HHHHHHCCCCCHHCC	30.19	25266776
557	Phosphorylation	LLRRSPKSYRSASPE HHHCCCCCHHCCCHH	29.21	25159016
558	Phosphorylation	LRRSPKSYRSASPER HHCCCCCHHCCCHHH	18.08	24759943
560	Phosphorylation	RSPKSYRSASPERTS CCCCCHHCCCHHHHC	25.51	27087446
562	Phosphorylation	PKSYRSASPERTSRK CCCHHCCCHHHHCCH	28.65	27087446
566	Phosphorylation	RSASPERTSRKSVRS HCCCHHHHCCHHHHH	31.08	27600695
567	Phosphorylation	SASPERTSRKSVRSD CCCHHHHCCHHHHHH	43.88	29514104
586	Phosphorylation	LEDGGQRSVHGTEVT HHHCCCCCCCCCCCC	15.58	26824392
590	Phosphorylation	GQRSVHGTEVTKQKH CCCCCCCCCCCCCCC	16.65	28066266
598	Phosphorylation	EVTKQKHTETVDKGL CCCCCCCCCCCCCCC	40.15	25777480
603	Acetylation	KHTETVDKGLSPAQK CCCCCCCCCCCHHHC	58.37	8276449
606	Phosphorylation	ETVDKGLSPAQKPKL CCCCCCCCHHHCCCC	27.19	26824392
615	Phosphorylation	AQKPKLASGTKPSAK HHCCCCCCCCCCCCH	58.39	28066266
617	Phosphorylation	KPKLASGTKPSAKSL CCCCCCCCCCCCHHH	36.97	28066266
625	Phosphorylation	KPSAKSLSSVKSDSH CCCCHHHHCCCCCCC	39.93	25266776
626	Phosphorylation	PSAKSLSSVKSDSHL CCCHHHHCCCCCCCC	38.57	25266776
629	Phosphorylation	KSLSSVKSDSHLGAY HHHHCCCCCCCCCCC	42.04	25266776
631	Phosphorylation	LSSVKSDSHLGAYSA HHCCCCCCCCCCCCC	27.92	29550500
637	Phosphorylation	DSHLGAYSAHKSENL CCCCCCCCCCCCCCC	24.30	-
640	Acetylation	LGAYSAHKSENLEDD CCCCCCCCCCCCCCC	60.21	8276459
740	Ubiquitination	ETMPLVIKGKSVKVC HHCCEEECCCEEEEE	53.45	-
783	Phosphorylation	KETDASKTMETVSSS HHCCCHHHHCCCCCC	20.11	28576409
786	Phosphorylation	DASKTMETVSSSSSA CCHHHHCCCCCCCCC	18.18	-
815	Phosphorylation	CAGKSAGSVKSVVTV CCCCCCCCCEEEEEE	26.53	29514104
818	Phosphorylation	KSAGSVKSVVTVAAK CCCCCCEEEEEEECC	21.47	29514104
845	Phosphorylation	KSLEAKKSGNIKNKD CCHHHHHCCCCCCCC	36.04	29514104
868	Phosphorylation	ANSEIKASSEDKATG CCCCCCCCCCCCCCC	29.29	25338131
869	Phosphorylation	NSEIKASSEDKATGK CCCCCCCCCCCCCCC	55.46	25338131
877	Phosphorylation	EDKATGKSAEESPSG CCCCCCCCCCCCCCC	42.11	25619855
881	Phosphorylation	TGKSAEESPSGTLEA CCCCCCCCCCCCCEE	18.83	25521595
883	Phosphorylation	KSAEESPSGTLEATE CCCCCCCCCCCEECC	54.40	25619855
885	Phosphorylation	AEESPSGTLEATEKE CCCCCCCCCEECCCC	26.26	25619855
889	Phosphorylation	PSGTLEATEKEPVNK CCCCCEECCCCCCCC	37.91	25293948
949	Phosphorylation	YIEINKKSADSMVKF EEEECCCCCCCCCEE	38.63	29895711
952	Phosphorylation	INKKSADSMVKFYTC ECCCCCCCCCEEEEE	25.78	29895711
1096	Phosphorylation	DLELGKGSTFSPDLK CCCCCCCCCCCCCCC	29.75	28833060
1097	Phosphorylation	LELGKGSTFSPDLKN CCCCCCCCCCCCCCC	36.48	28833060
1099	Phosphorylation	LGKGSTFSPDLKNSP CCCCCCCCCCCCCCC	20.00	26824392
1105	Phosphorylation	FSPDLKNSPVDESEV CCCCCCCCCCCHHHH	25.39	23375375
1110	Phosphorylation	KNSPVDESEVQTAAD CCCCCCHHHHHHCCC	38.31	23375375
1124	Phosphorylation	DSSSVKPSEVEEETT CCCCCCHHHCCCHHH	48.86	25338131
1130	Phosphorylation	PSEVEEETTSNIGTE HHHCCCHHHCCCCCC	38.51	25338131
1131	Phosphorylation	SEVEEETTSNIGTET HHCCCHHHCCCCCCC	24.05	25338131
1132	Phosphorylation	EVEEETTSNIGTETS HCCCHHHCCCCCCCC	33.59	25338131
1156	Phosphorylation	EPKQALCESDFAIQT CHHHHHHHCCCEEEE	54.94	24719451
1156 (in isoform 2)	Phosphorylation	-	54.94	25367039
1157 (in isoform 2)	Phosphorylation	-	36.71	25367039
1242	Phosphorylation	IKGIIEDSPSETEDI CCCCCCCCCCCCHHH	19.96	23375375
1244	Phosphorylation	GIIEDSPSETEDIFS CCCCCCCCCCHHHHH	62.19	23375375
1396	Phosphorylation	SKSSIKATVVSSPKA CCCCEEEEEECCCCC	19.21	27149854
1399	Phosphorylation	SIKATVVSSPKAKST CEEEEEECCCCCCCC	36.26	22324799
1400	Phosphorylation	IKATVVSSPKAKSTP EEEEEECCCCCCCCC	20.86	26824392
1569	Phosphorylation	RKEALKISPSPELNL CHHHHHCCCCCCCCC	20.10	25521595
1571	Phosphorylation	EALKISPSPELNLKK HHHHCCCCCCCCCCC	24.98	26824392
1633	Phosphorylation	MEEMVKNSNSLLTLD HHHHHHHCCCEEEHH	23.29	25159016
1635	Phosphorylation	EMVKNSNSLLTLDEL HHHHHCCCEEEHHHH	25.28	25159016
1638	Phosphorylation	KNSNSLLTLDELIDQ HHCCCEEEHHHHCCC	37.14	23984901
1661	Phosphorylation	PKDVTVLSMAEEQDL CCCCEEEECCCHHCC	16.17	28066266
1696	Ubiquitination	TFATLNAKRDKRDSI EEEEECCCCCCCCCC	61.12	-
1846	Phosphorylation	RVRLGKSSPSQKVAE CCCCCCCCCCCCCCC	31.86	-
1864	Phosphorylation	GEEAFQMSEGVDDAE CHHHHHCCCCCCHHH	22.03	-
1884	Phosphorylation	PDEKRRKTQDSSVGK CCHHHHHCCCCCCCC	35.48	21183079
1887	Phosphorylation	KRRKTQDSSVGKSMT HHHHCCCCCCCCHHC	19.67	21183079
1888	Phosphorylation	RRKTQDSSVGKSMTS HHHCCCCCCCCHHCC	43.08	21183079
1932	Phosphorylation	MANHCKSTRHKQNTE HHHHHHHHHHHHHHH	23.45	28576409
1954	Phosphorylation	KEKEQNETEERSSR- HHHHHHHHHHHHCC-	51.17	20495213
1958	Phosphorylation	QNETEERSSR----- HHHHHHHHCC-----	33.47	29899451
1959	Phosphorylation	NETEERSSR------ HHHHHHHCC------	48.51	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN638_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN638_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN638_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN638_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.