CNOT3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNOT3_MOUSE
• UniProt AC: Q8K0V4
• Protein Name: CCR4-NOT transcription complex subunit 3
• Gene Name: Cnot3
• Organism: Mus musculus (Mouse).
• Sequence Length: 751
• Subcellular Localization: Nucleus . Cytoplasm, P-body . NANOS2 promotes its localization to P-body.
• Protein Description: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages..
• Protein Sequence: MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQKEKYEADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLIENRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKDKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDLDLEDIPQALVATSPPSHSHMEDEIFNQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPTTSALSSTPGNNGASTPAAPTSALGPKASPAPSHNSGTPAPYAQAVAPPNASGPSNAQPRPPSAQPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSYSSVVADSPAEVTLSSSGGSSASSQALGPTSGPHNPAPSTSKESSTAAPSGAGNVASGSGNNSGGPSLLVPLPVNPPSSPTPSFSEAKAAGTLLNGPPQFSTTPEIKAPEPLSSLKSMAERAAISSGIEDPVPTLHLTDRDIILSSTSAPPTSSQPPLQLSEVNIPLSLGVCPLGPVSLTKEQLYQQAMEEAAWHHMPHPSDSERIRQYLPRNPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFHTKYMMWFQRHEEPKTITDEFEQGTYIYFDYEKWGQRKKEGFTFEYRYLEDRDLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
194	Phosphorylation	LRMLDNDSILVDAIR HHHHCCCCHHHHHHH	24.87	-
291	Phosphorylation	DDKKRGRSTDSEVSQ HHHHCCCCCCHHHHC	39.11	25521595
292	Phosphorylation	DKKRGRSTDSEVSQS HHHCCCCCCHHHHCC	42.03	25521595
294	Phosphorylation	KRGRSTDSEVSQSPA HCCCCCCHHHHCCCC	39.73	25266776
297	Phosphorylation	RSTDSEVSQSPAKNG CCCCHHHHCCCCCCC	22.38	22324799
299	Phosphorylation	TDSEVSQSPAKNGSK CCHHHHCCCCCCCCC	21.22	25521595
358	Phosphorylation	SALGPKASPAPSHNS CCCCCCCCCCCCCCC	27.93	25338131
381	Phosphorylation	AVAPPNASGPSNAQP CCCCCCCCCCCCCCC	58.85	25338131
384	Phosphorylation	PPNASGPSNAQPRPP CCCCCCCCCCCCCCC	48.61	25338131
392	Phosphorylation	NAQPRPPSAQPSGGS CCCCCCCCCCCCCCC	42.07	25338131
407	Phosphorylation	GGGSGGSSSNSNSGT CCCCCCCCCCCCCCC	36.49	25338131
434	Phosphorylation	YSSVVADSPAEVTLS CCEEEECCCCEEEEE	19.10	22067460
449	Phosphorylation	SSGGSSASSQALGPT CCCCCCCCCCCCCCC	25.57	-
450	Phosphorylation	SGGSSASSQALGPTS CCCCCCCCCCCCCCC	21.13	-
470	Phosphorylation	APSTSKESSTAAPSG CCCCCCCCCCCCCCC	36.40	25777480
471	Phosphorylation	PSTSKESSTAAPSGA CCCCCCCCCCCCCCC	24.13	25777480
472	Phosphorylation	STSKESSTAAPSGAG CCCCCCCCCCCCCCC	35.80	25777480
476	Phosphorylation	ESSTAAPSGAGNVAS CCCCCCCCCCCCCCC	36.23	25777480
483	Phosphorylation	SGAGNVASGSGNNSG CCCCCCCCCCCCCCC	29.25	25777480
485	Phosphorylation	AGNVASGSGNNSGGP CCCCCCCCCCCCCCC	35.53	25777480
489	Phosphorylation	ASGSGNNSGGPSLLV CCCCCCCCCCCCEEE	49.48	25777480
493	Phosphorylation	GNNSGGPSLLVPLPV CCCCCCCCEEEECCC	37.30	25777480
504	Phosphorylation	PLPVNPPSSPTPSFS ECCCCCCCCCCCCHH	50.65	23737553
505	Phosphorylation	LPVNPPSSPTPSFSE CCCCCCCCCCCCHHH	38.27	27087446
507	Phosphorylation	VNPPSSPTPSFSEAK CCCCCCCCCCHHHHH	33.25	23737553
509	Phosphorylation	PPSSPTPSFSEAKAA CCCCCCCCHHHHHHH	43.83	23737553
511	Phosphorylation	SSPTPSFSEAKAAGT CCCCCCHHHHHHHHH	40.77	23737553
518	Phosphorylation	SEAKAAGTLLNGPPQ HHHHHHHHCCCCCCC	24.28	26239621
527	Phosphorylation	LNGPPQFSTTPEIKA CCCCCCCCCCCCCCC	26.56	26239621
528	Phosphorylation	NGPPQFSTTPEIKAP CCCCCCCCCCCCCCC	47.89	26239621
529	Phosphorylation	GPPQFSTTPEIKAPE CCCCCCCCCCCCCCC	20.09	26824392
539	Phosphorylation	IKAPEPLSSLKSMAE CCCCCCHHHHHHHHH	44.32	28066266
540	Phosphorylation	KAPEPLSSLKSMAER CCCCCHHHHHHHHHH	47.72	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNOT3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNOT3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNOT3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNOT3_HUMAN	CNOT3	physical	20360068
RN219_HUMAN	RNF219	physical	20360068
CNOT9_HUMAN	RQCD1	physical	20360068
CNO11_HUMAN	CNOT11	physical	20360068
CNOT7_HUMAN	CNOT7	physical	20360068
CNOT8_HUMAN	CNOT8	physical	20360068
TOB2_HUMAN	TOB2	physical	20360068
CNO10_HUMAN	CNOT10	physical	20360068
CNOT1_HUMAN	CNOT1	physical	20360068
TB182_HUMAN	TNKS1BP1	physical	20360068
FHL2_HUMAN	FHL2	physical	20360068
CNOT6_HUMAN	CNOT6	physical	20360068
CNO6L_HUMAN	CNOT6L	physical	20360068
CNOT2_HUMAN	CNOT2	physical	20360068
RAVR1_HUMAN	RAVER1	physical	20360068
BTG3_HUMAN	BTG3	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.