FBX28_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX28_MOUSE
• UniProt AC: Q8BIG4
• Protein Name: F-box only protein 28
• Gene Name: Fbxo28
• Organism: Mus musculus (Mouse).
• Sequence Length: 368
• Subcellular Localization: Chromosome, centromere, kinetochore .
• Protein Description: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation..
• Protein Sequence: MAAASEERMAEEGGGGHGDGGSCSAAGSAQRQPPAPPSQAPPPGSQAPAAPALAPDHLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERFHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVRTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGTSSGSGQSEESPRKRRKATEAIDSLRKSKRLRNRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	Phosphorylation	FMSYDEISQLRLVCK HCCHHHHHHHHHHHH	22.55	27180971
235	Phosphorylation	VSGRLMGSPPVPGPS CCCCCCCCCCCCCCC	16.44	26643407
242	Phosphorylation	SPPVPGPSAALTTMQ CCCCCCCCHHHHHHH	31.89	26643407
263	Ubiquitination	PSRQEVTKLQQQVRT CCHHHHHHHHHHHHH	49.85	27667366
270	Phosphorylation	KLQQQVRTNGAGVTV HHHHHHHHCCCCHHH	38.86	-
330	Phosphorylation	KLREVMESAVGTSSG HHHHHHHHHHCCCCC	15.34	25777480
334	Phosphorylation	VMESAVGTSSGSGQS HHHHHHCCCCCCCCC	17.08	25777480
335	Phosphorylation	MESAVGTSSGSGQSE HHHHHCCCCCCCCCC	27.12	25777480
336	Phosphorylation	ESAVGTSSGSGQSEE HHHHCCCCCCCCCCC	36.49	25777480
338	Phosphorylation	AVGTSSGSGQSEESP HHCCCCCCCCCCCCH	35.29	25266776
341	Phosphorylation	TSSGSGQSEESPRKR CCCCCCCCCCCHHHH	47.02	25619855
344	Phosphorylation	GSGQSEESPRKRRKA CCCCCCCCHHHHHHH	26.42	27087446
352	Phosphorylation	PRKRRKATEAIDSLR HHHHHHHHHHHHHHH	29.05	21454597
357	Phosphorylation	KATEAIDSLRKSKRL HHHHHHHHHHHHHHH	24.78	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX28_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX28_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX28_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LCLT1_MOUSE	Lclat1	physical	26604221

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.